Locol Plus
Locol Plus Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Locol Plus is a brand name. Its generic name is Amlodipine + Atorvastatin.
Introduction
Locol Plus is a combination of two medications used for the treatment of high blood pressure, angina, and certain other heart conditions. It combines amlodipine, a calcium channel blocker used to treat high blood pressure, and atorvastatin, a statin used to reduce cholesterol.
Uses For
Locol Plus is used to treat high blood pressure, angina, and certain other heart conditions. It may also be used to reduce the risk of heart attack and stroke in people with certain risk factors.
Mechanism Of Action
Amlodipine works by relaxing the blood vessels and reducing the pressure on the heart. Atorvastatin works by blocking the action of an enzyme in the liver that prevents cholesterol from being broken down. This reduces the amount of cholesterol in the blood.
How Long Does It Take To Work?
Locol Plus usually starts to work within a few weeks. But it may take several months before the full effect is seen.
Absorption
Amlodipine is rapidly absorbed after oral administration and the peak effect is usually seen in 2-4 hours. Atorvastatin is moderately and rapidly absorbed.
Route Of Elimination
Amlodipine and atorvastatin are metabolised primarily in the liver. A small amount is also excreted unchanged in the urine.
Dosage
The usual starting dose of amlodipine + atorvastatin is 5mg/10mg per day. Doses can be increased up to 10mg/40mg per day depending on individual needs.
Administration
Amlodipine and atorvastatin should be taken with food at the same time each day. For best results, it is important to take this medication on a regular schedule.
Side Effects
The most common side effects of Locol Plus include headache, dizziness, fatigue, and nausea. Other side effects may include diarrhea, constipation, mild stomach pain, abdominal swelling, and joint pain.
Toxicity
Amlodipine and atorvastatin are generally safe medications, but if taken in large doses, they may cause serious side effects. Seek immediate medical attention if you experience any signs of an allergic reaction.
Precaution
Locol Plus should be used with caution in patients with liver or kidney problems, as well as in those with a history of heart disease, stroke or bleeding. It is important to tell your doctor about any other medications you are taking, as there may be interactions that can lead to side effects or reduced effectiveness.
Interactions
Locol Plus can interact with many other medications. It is important to tell your doctor about all the medications you are taking, including both prescription and over-the-counter medications, herbs and supplements.
Disease Interaction
Locol Plus can interact with some diseases or medical conditions, such as diabetes, liver disease, or kidney disease. It is important to talk to your doctor before taking this medication if you have any of these conditions.
Drug Interaction
Locol Plus can interact with other medications. It is important to tell your doctor about all the medications you are taking, as some drugs may increase or decrease the effectiveness of this medication. Common drug interactions include aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), potassium supplements, and diuretics.
Food Interactions
There are no known food interactions with Locol Plus. However, it is important to tell your doctor about any dietary supplements or herbs you are taking, as some may interact with this medication.
Pregnancy Use
Locol Plus should be used with caution in pregnant women. Studies have not been done to assess the safety of this medication in pregnant women, so it is best to use it only if clearly needed.
Lactation Use
Locol Plus should be used with caution in nursing women. The safety of this medication in breastfeeding has not been established, so it is best to use it only if clearly needed.
Acute Overdose
An overdose of Locol Plus can be dangerous and could be fatal. Seek immediate medical attention if you think you have taken too much of this medication.
Contraindication
Locol Plus should not be taken by people with an allergy to either of the active ingredients or to any of the inactive components. It should also not be taken by people with severe liver or kidney disease.
Use Direction
Take Locol Plus exactly as prescribed by your doctor. It is important to take this medication regularly and at the same time each day. Do not increase or decrease your dose without consulting your doctor.
Storage Conditions
Locol Plus should be stored at room temperature away from direct sunlight and heat. Do not store this medication in the bathroom as it may be affected by moisture.
Volume Of Distribution
Locol Plus has an average volume of distribution of 1.2 L/kg.
Half Life
Amlodipine has an average half life of 35 hours, while atorvastatin has an average half life of 14 hours.
Clearance
Locol Plus has an average clearance of 30ml/min.
Here you find in details version of Locol Plus
Some Frequently Asked Questions About Locol Plus
.What is Locol Plus?
Locol Plus is a combination medication used to treat high blood pressure and high cholesterol levels. The combination is made up of two drugs, amlodipine and atorvastatin. Amlodipine is a type of drug called a calcium channel blocker, which works by widening the arteries and helping blood pressure stay normal. Atorvastatin is a type of drug called a statin, a cholesterol-lowering medication.
What is the usual dosage of Locol Plus?
The dosage of Locol Plus depends on many factors, including the patient's age, medical history, and other medications they are taking. It is important to follow the directions from a doctor when taking this medication. Most often, the recommended starting dose is 1-2 tablets of 2.5 mg/20 mg taken once daily.
What are the potential side-effects of Locol Plus?
Some of the most common side-effects of Locol Plus include fatigue, headache, dizziness, nasal congestion, chest pain, nausea, and diarrhea. Other side-effects could include muscle pain, back pain, abnormal liver tests, joint pain, insomnia, and upper respiratory tract infection.
Can Locol Plus be used in combination with other medications?
Yes, Locol Plus can be used in combination with other medications, but it is important to talk to a doctor or pharmacist before taking any other medication. Certain medications can interfere with or reduce the effectiveness of Locol Plus, so it is important to discuss potential medications with a healthcare professional.
What are the possible drug interactions associated with Locol Plus?
Locol Plus should not be taken with other medications that have a similar action or could lead to adverse reactions. This includes other calcium channel blocker medications, some antibiotics, and certain anti-depressants. Alcohol and grapefruit juice may also interact with Locol Plus, and should be avoided while taking the medication.
What are the contraindications associated with Locol Plus?
Locol Plus is generally safe for most people, but there are a few situations in which it should not be taken. People with a history of liver or kidney disease, or a history of statin-related muscle problems, should not take Locol Plus. Women who are pregnant or breastfeeding should also not take Locol Plus.
Is Locol Plus safe to take in the long-term?
Yes, Locol Plus is safe to take in the long-term when the drug is taken as prescribed by a healthcare professional. However, regular blood tests are important to monitor for any potential side effects or long-term damage that can occur from taking the medication.
How long does it take for Locol Plus to take effect?
The effects of Locol Plus can be seen within one to two weeks, but the full effects may take up to four to six weeks. It is important to take the medication as prescribed and follow up with regular blood tests to check for any side effects.
Should certain foods be avoided while taking Locol Plus?
Yes, certain foods should be avoided while taking Locol Plus. Avoid eating high-fat and high-cholesterol foods such as butter, red meats, egg yolks, and fried foods. Also, it is important to limit your intake of salt. Alcohol should also be avoided while taking Locol Plus.
What if I miss a dose of Locol Plus?
If you miss a dose of Locol Plus, take the missed dose as soon as possible, unless it is almost time for your next dose. Do not double up on doses. If you are unsure, it is best to contact your healthcare provider for further advice.
What should I do if I experience a side effect from taking Locol Plus?
If you experience any side effects from taking Locol Plus, contact your healthcare provider as soon as possible. It is important to monitor for any potential side effects in order to adjust your dose or discontinue use of the drug.
Is Locol Plus safe for everyone?
No, Locol Plus is not safe for everyone. Locol Plus should not be taken by patients with known allergies to either amlodipine or atorvastatin, or by pregnant or breastfeeding women. It is also not recommended for people with kidney or liver disease, or any history of statin-related side effects.
What should I tell my healthcare provider before taking Locol Plus?
Before taking Locol Plus, it is important to tell your healthcare provider about all medications you are taking, including any over-the-counter drugs, herbal remedies, and supplements. It is also important to let your healthcare provider know if you have any contact allergies, or if you have any medical conditions, such as kidney or liver disease.
Can Locol Plus be used to treat other conditions?
No, Locol Plus is only approved to treat high blood pressure and high cholesterol. It should not be taken for any other purpose unless directly instructed by a healthcare provider.
Can I take Locol Plus while pregnant or breastfeeding?
No, it is not recommended to take Locol Plus during pregnancy or while breastfeeding. It is important to discuss your options with your healthcare provider, as other therapies may be recommended.
Does Locol Plus have to be taken at a specific time?
No, Locol Plus does not have to be taken at a specific time. However, it is important to take it consistently at the same time each day in order to maximize its effectiveness. It is also important to discuss any potential interactions with other medications with your healthcare provider.
What should I do if I accidentally take an extra dose of Locol Plus?
If you accidentally take an extra dose of Locol Plus, contact your healthcare provider right away. Do not take a double dose of this medication. Your healthcare provider will provide instructions on how to safely reduce your dose.
Are there any alternatives to Locol Plus?
Yes, there are alternatives to Locol Plus. These include other blood pressure and cholesterol medications, such as ACE inhibitors, angiotensin II receptor blockers, and fibrates. These medications should be discussed with a healthcare provider, as they may be more appropriate for certain patients.
Can I take Locol Plus with an over-the-counter pain reliever?
Yes, it is usually safe to take Locol Plus with an over-the-counter pain reliever such as ibuprofen, acetaminophen, or naproxen. However, it is important to talk to your healthcare provider or pharmacist before taking any over-the-counter medications.
Can Locol Plus cause a skin rash or other allergic reaction?
Locol Plus may cause a skin rash or other allergic reaction in some people. Contact your healthcare provider right away if you experience any itching, rash, hives, or other allergic symptoms.
Is Locol Plus safe for people with diabetes?
Yes, Locol Plus is considered safe for people with diabetes. This medication may help lower the patient’s blood pressure and cholesterol levels, which can be beneficial for people with diabetes. However, it is important to discuss any medications and supplements you are taking with your healthcare provider.
Are there any foods or drinks that should be avoided while taking Locol Plus?
Yes, it is important to avoid certain foods and drinks while taking Locol Plus. Avoid eating high-fat and high-cholesterol foods such as butter, red meats, egg yolks, and fried foods. Also, it is important to limit your intake of salt. Alcohol should also be avoided while taking Locol Plus.
If I forget to take Locol Plus, what should I do?
If you forget to take a dose of Locol Plus, take the missed dose as soon as possible, unless it is almost time for your next dose. Do not double up on doses. If you are unsure, it is best to contact your healthcare provider for further advice.
Can I take other medications while taking Locol Plus?
Yes, other medications can be taken while taking Locol Plus, but it is important to talk to a doctor or pharmacist before taking any other medication. Certain medications can interfere with or reduce the effectiveness of Locol Plus, so it is important to discuss potential medications with a healthcare professional.
Does Locol Plus have any interactions with other medications?
Yes, Locol Plus can interact with other medications. Locol Plus should not be taken with other medications that have a similar action or could lead to adverse reactions. This includes other calcium channel blocker medications, some antibiotics, and certain anti-depressants. Alcohol and grapefruit juice may also interact with Locol Plus, and should be avoided while taking the medication.
Does Locol Plus cause dizziness?
Yes, Locol Plus can cause dizziness. If you experience dizziness while taking Locol Plus it is important to contact your healthcare provider right away.
Can I consume grapefruit juice while taking Locol Plus?
No, it is not recommended to consume grapefruit juice while taking Locol Plus. Grapefruit juice has been shown to interact with this medication, and may increase the risk of side effects.
How can I tell if Locol Plus is working?
It may take several weeks for Locol Plus to take effect. The best way to tell if the medication is working is to have regular blood tests to monitor your cholesterol and blood pressure levels. You may also experience improved energy levels and a reduction in symptoms of high blood pressure.
Are there any foods that can affect the effectiveness of Locol Plus?
Yes, there are certain foods that can affect the effectiveness of Locol Plus. Avoid eating high-fat and high-cholesterol foods such as butter, red meats, egg yolks, and fried foods. Also, it is important to limit your intake of salt. These dietary modifications can help ensure the optimal effectiveness of Locol Plus.