Locaine

Locaine Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Locaine is a brand name. Its generic name is Lidocaine.

Locaine

Locaine is a local anesthetic drug that is available in multiple forms, including injection, ointment, cream, oral spray, and patch.

Uses for Locaine

Locaine is typically used to relieve pain, either alone or in combination with opioids, such as oxycodone or morphine. It is also commonly used in dentistry to temporarily numb the area before and/or after a procedure. Other indications for use include prevention of ventricular fibrillation and cardiac arrhythmias, when no other treatments are effective.

Mechanism of Action

Locaine’s mechanism of action involves binding to voltage-gated sodium channels in nerve cell membranes. This inhibits the entry of sodium ions into the cell, causing nerve cell depolarization and subsequent blockage of nerve impulse transmission. As a result, sensory nerve fibers are blocked and the area of the body treated by lidocaine is temporarily numb.

How Long Does it Take to Work?

Locaine typically takes 1 to 2 minutes to start working. Depending on the type of lidocaine used, the effects can last for 30 minutes to several hours.

Absorption

In general, lidocaine is slowly and erratically absorbed when applied to intact skin or mucous membrane. For systemic use, it is most often given by injection.

Route of Elimination

Locaine is primarily eliminated through the kidneys as unchanged drug. A small amount is eliminated through the liver via hydroxylation and glucuronic acid conjugation.

Dosage

The specific dose of lidocaine that is appropriate for each individual depends on the type and severity of the medical condition being treated. It is important to follow the directions provided on the product packaging or by a healthcare professional. Generally, lidocaine is available in the following doses:

• Topical ointment, cream, or spray: 2-10 percent.
• Jelly or liquid: 0.5-5 percent.
• Trans buccal oral spray: 2 mg/spray (starter dose of 4 sprays).
• Patch: 4.5-9 mg/hour.
• Injection: lidocaine is given intravenously by bolus and continuous infusion in doses of 1.5-4 mg/minute.

Administration

Locaine is most commonly administered as an injection, topical cream, or patch. The topical preparations are commonly used to numb the area before or after a procedure and the injection is commonly given for nerve blockages and cardiac arrhythmias. The patch is used primarily to provide prolonged relief from pain.

Side Effects

Common side effects of lidocaine use can include: skin irritation, drowsiness, tremors, nausea, vomiting, dizziness, lightheadedness, headache, palpitations, and changes in blood pressure.

Toxicity

When too much lidocaine is given, toxicity can occur. Symptoms of toxicity may include seizures, muscle twitching, confusion, changes in heart rate and rhythm, and respiratory depression. Treatment of lidocaine toxicity includes stopping the drug and providing medical support as needed.

Precautions

When using lidocaine, it is important to follow the directions on the product label or as given by a healthcare professional. In addition, certain medical conditions could make use of lidocaine inappropriate or dangerous, so it is important to discuss any underlying medical conditions with a healthcare provider prior to use.

Interactions

Locaine can interact with certain prescription drugs, over-the-counter drugs, herbal products, and foods. It is important to provide a complete list of all medications and other substances that you are taking to your doctor or pharmacist when requesting or renewing a prescription for lidocaine.

Disease Interactions

Individuals with certain medical conditions may experience adverse reactions to using lidocaine. These conditions include kidney or liver disease, heart disease, seizures, and allergies to local anesthetics. It is important to discuss any existing medical conditions with your primary care provider before using lidocaine.

Drug Interactions

Locaine may interact with certain drugs. For example, lidocaine should not be used with amiodarone or flecainide, as the combination may increase the risk of serious side effects. Additionally, lidocaine should not be used with certain antifungal medications or antibiotics such as erythromycin or clarithromycin. Always speak with your doctor or pharmacist before using any medication in combination with lidocaine.

Food Interactions

Locaine does not typically interact with food or drinks. However, it is important to check with your doctor or pharmacist if you have any questions or concerns.

Pregnancy Use

The use of lidocaine during pregnancy is not generally recommended. If it is necessary to use lidocaine during pregnancy, it should be used with caution and monitoring from a healthcare professional.

Lactation Use

Locaine is not recommended for use in breastfeeding mothers. If lidocaine is used, it should be used with caution and monitoring from a healthcare professional.

Acute Overdose

Acute overdose with lidocaine is a medical emergency. Treatment for an overdose includes supportive care such as controlling vital signs and providing oxygen or ventilation support. Severe symptoms may require intubation and airway support.

Contraindication

Locaine should not be used in people who are sensitive or allergic to local anesthetics or certain additives such as sodium metabisulfite; people with a history of severe heart problems, seizures, or abnormal heart rhythms; people with certain metabolic or neurologic diseases; and people with an altered mental status.

Use Direction

Locaine should be used as directed by a healthcare professional or according to the directions on the product label. It is important to follow the directions carefully and to not exceed the recommended dose.

Storage Condition

Locaine should be stored in a tightly closed container and kept at room temperature. It should be kept away from heat, light, and moisture. In addition, it should never be stored in a shared place or near flammable substances.

Volume of Distribution

The volume of distribution of lidocaine is approximately 3-7 liters per kilogram, depending on the individual. This means that it will be distributed throughout the body before being eliminated.

Half Life

The half-life of lidocaine ranges from 1.5 to 2.5 hours, depending on the individual. This means that it will take approximately 2.5 to 6.5 hours for the lidocaine to be eliminated from the body.

Clearance

Locaine is cleared from the body mainly by the liver and the kidneys, with some excretion through the bile. The clearance rate is variable and can range from 0.2 to 6.6 liters per hour.

Here you find in details version of Locaine

Some Frequently Asked Questions About Locaine

What is Locaine?

Locaine is a local anesthetic used to numb an area of the body. It works by blocking nerve signals in the body to prevent the body from feeling pain.

How long does Locaine last?

The duration of action of Locaine depends on the route of administration. When applied topically, the effects can last up to 8 hours. When injected, the effects of Locaine can last up to 2 hours.

What are the side effects of Locaine?

The most common side effects of Locaine are mild skin irritation at the injection site, itching, and lightheadedness. Other more serious side effects may include blurred vision, difficulty breathing, dizziness, and seizures.

Is Locaine safe for children?

Yes, Locaine is generally safe for children when used under the supervision of a healthcare professional. The dosage administered should be according to the child's age and weight.

Can Locaine be used for toothache?

Yes, Locaine is often used in the treatment of toothaches, as it can provide temporary pain relief while the underlying cause of the toothache is being investigated.

Can Locaine be bought over the counter?

No, Locaine is a prescription-only medicine. It is only available with a valid prescription from a healthcare professional.

What are the common uses of Locaine?

The most common uses of Locaine are for topical pain relief, as an anesthetic before certain procedures, and to provide pain relief during childbirth.

Can Locaine be used to treat a sunburn?

Yes, Locaine can be used for the temporary relief of minor sunburns. It works by numbing the area and providing temporary relief.

What precautions should be taken when using Locaine?

Locaine should only be taken as directed by a healthcare professional and must not be administered without the supervision of a medical professional. It should also not be used for long periods of time, and other medications and allergies should be taken into consideration before taking this medication.

Can Locaine be used for muscle pain?

Yes, Locaine can be used for the temporary relief of muscular pain. However, it should not be used as a regular method of pain relief, and other forms of treatment should be considered first.

What is the recommended dosage of Locaine?

The dose of Locaine will vary depending on the route of administration and the indication for use. It is important to follow the specific dosing instructions provided by your doctor or pharmacist.

Can Locaine be used for nerve pain?

Yes, Locaine is commonly used as a local anesthetic to reduce nerve pain and discomfort. It is important to follow the specific instructions provided by your doctor or pharmacist.

Can Locaine be used while pregnant or breastfeeding?

Locaine should not be used while pregnant or breastfeeding unless it has been prescribed by a healthcare professional. It is important to discuss the potential risks and benefits of this medication with your doctor before taking it.

Can Locaine be used for a sore throat?

No, Locaine is not typically used for the treatment of sore throat. Other medications such as analgesics, anti-inflammatory drugs, or throat lozenges may be more effective in the treatment of sore throat.

What are the signs of an allergic reaction to Locaine?

Signs of an allergic reaction to Locaine include itching, rash, difficulty breathing, dizziness, and swelling of the face, lips, or tongue. If you experience any of these symptoms, seek immediate medical attention.

Can Locaine be used for itching?

Yes, Locaine can be used to provide temporary relief of itching. However, it should not be used as a regular method of treating itching, and other treatment options should be considered first.

Can Locaine be used for migraine headaches?

No, Locaine is not typically used for the treatment of migraine headaches. Other medications such as analgesics and anti-inflammatory drugs may be more effective in the treatment of migraines.

Can Locaine be used for burns?

Yes, Locaine can be used to provide temporary relief of minor burns. However, it should not be used as a regular method of treating burns, and other treatment options should be considered first.

What should I do if I miss a dose of Locaine?

If you miss a dose of Locaine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose as scheduled.

Is Locaine a narcotic?

No, Locaine is not a narcotic. It is a local anesthetic that is used to provide temporary pain relief.

Are there any food or drink restrictions while taking Locaine?

No, there are no food or drink restrictions while taking Locaine. However, it is important to follow the directions of your doctor or pharmacist.

Can Locaine be used for leg cramps?

Yes, Locaine can be used to provide temporary relief of leg cramps. However, it should not be used as a regular method of treating leg cramps, and other treatment options should be considered first.

How long does it take for Locaine to take effect?

The time it takes for Locaine to take effect will vary depending on the route of administration and the indication for use. Generally, the effects can be felt within minutes of administration.

What should I do if I experience an overdose of Locaine?

If you think you have taken an overdose of Locaine, seek immediate medical attention. Signs of an overdose include dizziness, nausea, difficulty breathing, and seizures.

How should Locaine be stored?

Locaine should be stored at room temperature and in a dry place away from direct sunlight. It should also be kept out of reach of children and pets.

Can Locaine be used for earaches?

Yes, Locaine can be used to provide temporary relief of earaches. However, it should not be used as a regular method of treating earaches, and other treatment options should be considered first.

Can Locaine be used for insect bites?

Yes, Locaine can be used to provide temporary relief of minor insect bites. However, it should not be used as a regular method of treating insect bites, and other treatment options should be considered first.

Can Locaine be used for post-operative pain?

Yes, Locaine is often used in the treatment of post-operative pain. It works by blocking the nerves in the area of the surgery, which reduces pain and discomfort.

Can Locaine be used for wound care?

Yes, Locaine is often used in wound care to reduce pain and discomfort. It can be used in conjunction with other wound care treatments, such as dressings and bandages.

Are there any other medications I should avoid while taking Locaine?

Yes, it is important to discuss any other medications you are taking, including over-the-counter medications, with your doctor before taking Locaine. Certain medications, such as antibiotics and antifungals, may interact with Locaine and cause side effects.