Lirel

Lirel Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Lirel is a brand name. Its generic name is Clopidogrel.

Introduction

Lirel is an antiplatelet medication used to reduce the risk of stroke and cardiovascular deaths in people with heart disease. It is also used to reduce the risk of recurring chest pain caused by a heart attack. Lirel works by preventing platelets in the blood from sticking together and forming clots that can lead to a stroke or heart attack.

Uses for

Lirel is used to reduce the risk of stroke and cardiovascular death in people with existing heart disease or who are at high risk of developing heart disease. It is also used to reduce the risk of recurrent chest pain caused by a heart attack. It is not used to treat chest pain when it occurs.

Mechanism of Action

Lirel prevents platelets from sticking together and forming clots that can lead to a stroke or heart attack. It does this by inhibiting the action of an enzyme called platelet activating factor (PAF). By blocking PAF, clopidogrel prevents the platelets from clumping together, which reduces the risk of stroke and heart attack.

How Long Does It Take To Work?

Lirel usually begins to work within 1 week of starting treatment. However, it may take up to 4 weeks for the full benefits of the medication to be seen.

Absorption

Lirel is rapidly and completely absorbed from the gastrointestinal tract after oral administration. The maximum plasma concentration is achieved 1 to 2 hours after oral administration.

Route of Elimination

Lirel is eliminated primarily by the liver. It is metabolized by the cytochrome P450 enzymes CYP2C19 and CYP3A4 and excreted in the feces. A small amount is also excreted in the urine.

Dosage

Lirel is taken orally in tablet form. The usual adult dose is 75 mg once daily without regard to meals. Dosage may be increased to 150 mg daily in some patients. The dose should not exceed 150 mg per day. Your doctor may adjust your dose based on your blood work or other medications you are taking.

Administration

Lirel should be taken with food. Swallow the tablet whole with a full glass of water. Do not break, crush, or chew the tablet.

Side Effect

Common side effects of Lirel include headache, dizziness, nausea, vomiting, diarrhea, constipation, rash, and fatigue. More serious side effects may include anemia, pancreatitis, gingival bleeding, heart rhythm disturbances, and thrombocytopenia.

Toxicity

Lirel has an LD50 of 5500 mg/kg in rats. Toxicity is rare except in cases of accidental overdose or in patients with liver or kidney damage taking large doses.

Precaution

Patients taking Lirel should avoid consuming alcohol as it can increase the risk of bleeding. Other drugs that may interact with Lirel include aspirin, NSAIDs, and warfarin. Tell your doctor about any medications you are taking before taking Lirel.

Interaction

Lirel may interact with other medications, including aspirin, NSAIDs, and warfarin. Tell your doctor about any medications you are taking before taking Lirel.

Disease Interaction

Lirel may interact with certain diseases, such as liver or kidney damage. It is important to tell your doctor about any diseases you may have before taking Lirel.

Drug Interaction

Certain drugs can interact with Lirel, including aspirin, NSAIDs, and warfarin. Tell your doctor about any medications you are taking before taking Lirel.

Food Interactions

Lirel should be taken with food. Avoid unhealthy fats (including trans fats) as they may reduce the absorption of Lirel and lower its effectiveness. Grapefruit and grapefruit juice may interact with Lirel and should be avoided.

Pregnancy Use

Lirel is classified as a Pregnancy Category C medication, which means that it is not known if it can harm an unborn baby. It is important to tell your doctor if you are pregnant or suspect you are pregnant before taking Lirel.

Lactation Use

Lirel should not be taken by breastfeeding women. It is not known if clopidogrel is excreted in human milk and it is not recommended for use during breastfeeding.

Acute Overdose

An overdose of clopidogrel may cause bleeding, difficulty breathing, or dizziness. If you or someone you know has taken an overdose of clopidogrel, seek immediate medical attention.

Contraindication

Lirel should not be used in patients who are hypersensitive to it, in patients with active bleeding, or in pregnant or breastfeeding women. Lirel should also not be used in patients who are taking anticoagulants such as warfarin.

Use Direction

Lirel is an oral medication taken once daily without regard to meals. The usual adult dose is 75 mg once daily but your doctor may adjust your dose based on your blood work or other medications you are taking. Swallow the tablet whole with a full glass of water. Do not break, crush, or chew the tablet.

Storage Condition

Lirel should be stored at room temperature, away from heat and direct light. It should be tightly closed in a cool, dry place.

Volume of Distribution

The volume of distribution of clopidogrel is 11 liters.

Half Life

The half life of clopidogrel is approximately 7 hours.

Clearance

The clearance of clopidogrel is 11 liters/hour.

Here you find in details version of Lirel

Some Frequently Asked Questions About Lirel

What is Lirel?

Lirel is a medication used to reduce the risk of stroke and heart attack in people who are at high risk. It is an antiplatelet drug, meaning it helps to prevent blood clots, and is often prescribed in combination with aspirin.

Who should take Lirel?

Lirel is commonly prescribed to those with a history of heart attack, stroke, or peripheral artery disease. It may also be recommended for those who have recently had a stent inserted, or who have unstable angina. Your doctor can advise if Lirel is right for you.

How does Lirel work?

Lirel works by blocking platelets from clumping together and forming clots in the arteries. By reducing the formation of clots in the arteries, Lirel can help to prevent heart attack, stroke and other cardiovascular events.

What are the common side effects of Lirel?

The most common side effects of Lirel include headache, diarrhea, nausea, indigestion, stomach pain and constipation. If any of these symptoms persist or worsen, contact your doctor as soon as possible.

Can I drink alcohol while taking Lirel?

It is not recommended to drink alcohol while taking Lirel as it can increase the risk of side effects. Ask your doctor if it is safe for you to drink alcohol while taking Lirel.

When should I take Lirel?

Lirel is taken once daily, usually in the morning. It is important to take it at the same time each day to ensure it is effective and to help you remember to take it.

How long does it take for Lirel to work?

Lirel starts to work within a few hours of taking it. It may take up to two weeks for the full effects of the medication to be seen.

Can I take other medications while taking Lirel?

Always tell your doctor or pharmacist about any medications or supplements you are taking while taking Lirel. Some medicines may interact and cause serious side effects, so it is important to have your doctor check that it is safe to take other medications while Lirel.

Can women take Lirel?

Yes, women can take Lirel, but pregnant women should not take it as it may have adverse effects on the unborn baby. It is also important to tell your doctor if you are breastfeeding as Lirel may pass into breast milk and may harm a nursing baby.

What should I do if I forget to take my Lirel?

If you forget to take your Lirel, take it as soon as you remember and then take your next dose at the usual time. Do not take a double dose to make up for the missed dose.

What happens if I overdose on Lirel?

If you take more Lirel than prescribed, contact your doctor immediately or go to the emergency room. Overdosing on Lirel can cause serious side effects or death.

Does Lirel have any interactions with food or alcohol?

There are no known interactions between food and Lirel, but alcohol can increase the risk of adverse side effects. It is not recommended to drink alcohol while taking Lirel.

What are the most serious side effects of Lirel?

The most serious side effects of Lirel include difficulty breathing, signs of bleeding (nosebleeds, bleeding gums, blood in urine or stool), vision loss or changes, severe dizziness, fainting, or signs of an allergic reaction (hives, rash, itching, swelling). Seek immediate medical attention if you experience any of these symptoms.

Is there a generic form of Lirel available?

Yes, there is a generic form of Lirel available in the US. However, it is important to note that the generic forms may not have the same ingredients as the brand name version, and they may not be as effective. Talk to your doctor to find out more.

What is the cost of Lirel?

The cost of Lirel varies depending on the form and brand of the medication you choose. Talk to your doctor or pharmacist to find out the cost of your prescription.

Can I take Lirel with other medications?

Always tell your doctor or pharmacist about any medications or supplements you are taking while taking Lirel. Your doctor may need to adjust your dose of Lirel if you are taking other medications, and some medicines may interact and cause serious side effects, so it is important to have your doctor check that it is safe to take other medications while taking Lirel.

Can Lirel be used to treat other conditions?

No, Lirel should not be used for any condition other than those for which it is prescribed by your doctor. Do not take Lirel for any other purpose, and never give Lirel to someone else.

Does Lirel cause weight gain?

Weight gain is not a common side effect of Lirel, but it is possible. If you notice any changes in your weight while taking Lirel, contact your doctor.

Can I take over-the-counter medication while taking Lirel?

Always tell your doctor or pharmacist about any medications or supplements you are taking while taking Lirel. Some over-the-counter medicines may interact with Lirel and cause serious side effects, so it is important to have your doctor check that it is safe to take other medications while taking Lirel.

What should I do if I have an allergic reaction to Lirel?

If you experience any signs of an allergic reaction to Lirel, such as rash, itching, hives, swelling, or difficulty breathing, discontinue use and contact your doctor immediately.

Can I stop taking Lirel if I'm feeling better?

No, it is important to take Lirel as prescribed for the duration of your treatment. Do not stop taking the medication without first consulting your doctor, as it may cause an increased risk of stroke and heart attack.

Does Lirel cause hair loss?

Hair loss is not a common side effect of Lirel, but it is possible. If you notice unusual hair loss while taking Lirel, contact your doctor.

Can I take Lirel while pregnant?

No, it is not safe to take Lirel while pregnant as it may cause serious harm to the unborn baby. If you are pregnant, contact your doctor immediately.

Can I take Lirel if I have kidney or liver problems?

If you have kidney or liver problems, your doctor may need to adjust your dose of Lirel. Talk to your doctor before starting Lirel if you have any kidney or liver issues.

What should I do if I experience severe stomach pain while taking Lirel?

If you experience severe stomach pain while taking Lirel, contact your doctor immediately. Severe stomach pain can be a sign of bleeding, which can be serious.

Can I take Lirel if I have a history of bleeding disorders?

Lirel can increase the risk of bleeding, so it is important to tell your doctor if you have a history of bleeding disorders before taking Lirel. Your doctor can advise if it is safe for you to take this medication.

What should I do if I experience muscle weakness while taking Lirel?

If you experience muscle weakness while taking Lirel, contact your doctor immediately. Muscle weakness can be a sign of muscle breakdown, which can be serious.

Can I take Lirel if I'm breastfeeding?

Talk to your doctor before taking Lirel if you are breastfeeding. Lirel can pass into breast milk and it may harm a nursing baby. Your doctor can advise on whether or not it is safe for you to take Lirel while breastfeeding.

Can I take Lirel if I have diabetes?

Yes, you can take Lirel if you have diabetes, but your doctor may need to adjust your dose. It is important to tell your doctor if you have diabetes so they can ensure that Lirel is safe for you.

Does Lirel interact with other medications?

Lirel may interact with other medications, including prescription, over-the-counter and herbal medications. Always tell your doctor or pharmacist about any medications or supplements you are taking while taking Lirel. Some medicines may interact and cause serious side effects, so it is important to have your doctor check that it is safe to take other medications while taking Lirel.

How long should I take Lirel?

Your doctor will determine how long you should take Lirel. It is important to take Lirel for as long as prescribed in order to ensure it is effective. Do not stop taking Lirel without first consulting your doctor.

What is the usual dose of Lirel?

The usual dose of Lirel is 75mg once daily. Your doctor may prescribe a different dose if needed. Always follow your doctor's instructions when taking Lirel.

Can I take herbal supplements while taking Lirel?

Always tell your doctor or pharmacist about any medications or supplements you are taking while taking Lirel. Some herbal supplements may interact with Lirel and cause serious side effects, so it is important to have your doctor check that it is safe to take other medications while taking Lirel.

Can Lirel cause dizziness?

Dizziness is a common side effect of Lirel. If you experience severe or persistent dizziness, contact your doctor.

Does Lirel cause blurred vision?

Blurred vision is not a common side effect of Lirel, but it is possible. If you experience blurry vision while taking Lirel, contact your doctor.

Is Lirel effective in treating heart attack and stroke?

Lirel is an antiplatelet drug, meaning it helps to prevent blood clots. It can reduce the risk of heart attack and stroke in those who are at high risk. Your doctor can advise if Lirel is right for you.

Can Lirel cause skin rash?

Skin rash is not a common side effect of Lirel, but it is possible. If you experience a skin rash while taking Lirel, contact your doctor.