Lexomide

Lexomide Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Lexomide is a brand name. Its generic name is Diloxanide Furoate.

Introduction

Lexomide is an antimicrobials drug used to treat certain parasitic infections. It belongs to the group of medication called anti-gastrointestinal amoebicides which works by killing the microorganisms causing the infection. It is commonly used to treat intestinal infection caused by E. histolytica.

Uses for

Lexomide is used to treat intestinal infections caused by Entamoeba histolytica. It can be used in older children and adults, and is most commonly used to treat diarrhea caused by the parasites.

Mechanism of action

Lexomide works by killing the microorganisms that cause the infection by blocking the ability of the parasites to make DNA. This prevents them from multiplying and eventually kills them.

How long does it take to work?

It typically takes a few days for the medication to be effective. Most people experience complete relief after taking Lexomide for 1-2 weeks.

Absorption

Lexomide is absorbed relatively well in the intestine, resulting in a peak plasma concentration after about 4 hours.

Route of Elimination

Lexomide is eliminated in urine as furoate or glucuronide metabolites. It undergoes both enterohepatic and renal recirculation and can reach detectable levels in the feces after 1-2 days.

Dosage

The usual dose of Lexomide for adults is 500 mg (2 tablets) orally every eight hours for 10 to 14 days. Children aged 12 and above should take 250 mg (one tablet) orally every eight hours for 10 to 14 days.

Administration

Lexomide should be taken orally, with or without food.

Side Effect

Common side effects of Lexomide include nausea, vomiting, abdominal cramps, diarrhea, rash, and headache. If any of these effects worsen or persist, contact your doctor.

Toxicity

Lexomide is generally well tolerated. In rare cases, severe allergic reactions to the medication can occur. In these cases, contact your doctor immediately.

Precautions

Before taking Lexomide, inform your doctor if you have any allergies, kidney disease, or any other medical condition. This medication can cause dizziness and drowsiness, so use caution when driving or operating heavy machinery. Avoid drinking alcoholic beverages while taking this medication.

Drug Interactions

Lexomide can interact with other medications, specifically antacids, other amoebicides, and certain antibiotics. Avoid taking these medications within 2 hours of taking Lexomide. If you are taking any of these medications, inform your doctor.

Food Interactions

Food can affect the absorption of Lexomide; therefore, take the medication with or without food. Avoid taking this medication with high fat meals, which can reduce its effectiveness.

Pregnancy Use

Pregnant women should avoid taking Lexomide as it can cause harm to the unborn baby.

Lactation Use

This medication is not recommended for use while breastfeeding as it can be excreted in breast milk and may cause harm to the baby.

Acute Overdose

Symptoms of an overdose include nausea, vomiting, excessive urination, dizziness, and confusion. If you or someone you know has taken an overdose, seek medical advice immediately.

Contraindication

This medication should not be used in patients with an allergy or sensitivity to Lexomide.

Use Direction

For best results, it is important to take Lexomide exactly as directed. Take the entire course of medication, even if symptoms improve after a few days. Do not stop taking the medication without consulting your doctor.

Storage Condition

It is important to store Lexomide at room temperature, in a cool, dry place. Keep out of reach of children and pets.

Volume of Distribution

The volume of distribution of Lexomide is approximately 0.7 L/kg.

Half Life

The half-life of Lexomide is approximately 1.9 +/- 0.8 hours.

Clearance

Lexomide has a renal clearance rate of approximately 0.9 +/- 0.3 L/hour/kg.

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