Lenvanix

Lenvanix Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Lenvanix is a brand name. Its generic name is Lenvatinib.

Introduction

Lenvanix is an oral tyrosine kinase receptor inhibitor used to treat certain types of cancer. It is used in combination with other drugs to specifically target some cancer cells and stop them from multiplying. Lenvanix has been approved by the US Food and Drug Administration (FDA) for the treatment of certain kinds of thyroid cancer and also for hepatocellular carcinoma.

Uses

Lenvanix is used to treat certain kinds of crab including:
  • Thyroid cancer
  • Hepatocellular Carcinoma

Mechanism of Action

Lenvanix works by inhibiting certain proteins called tyrosine kinase receptors, which play a role in the growth and spread of cancer cells. By inhibiting this receptor, lenvatinib stops cancer cells from multiplying and further spreading in the body.

How Long Does It Take to Work?

It may take some time for the effects of lenvatinib to be seen. The amount of time will vary from person to person and depend on the kind of cancer and the severity. Make sure to follow your doctor's instructions closely and take lenvatinib as prescribed.

Absorption

After administration of lenvatinib orally, it is rapidly and completely absorbed from the gastrointestinal tract, and peak levels are achieved within 1 to 3 hours.

Route of Elimination

Lenvanix is primarily excreted by the kidneys and a small fraction is excreted unchanged in the urine.

Dosage

The dosage of lenvatinib for treating different types of cancer is as follows:
  • Thyroid cancer: The recommended starting dose of lenvatinib for this is 18 mg once daily.
  • Hepatocellular carcinoma: The recommended starting dose of lenvatinib for this is 14 mg once daily.

Administration

Lenvanix should be taken orally once daily at the same time every day, with or without food. It is important to not miss doses as this might reduce the effectiveness of the medication.

Side Effects

The most common side effects associated with lenvatinib are
  • Fatigue
  • Diarrhea
  • Nausea
  • Loss of appetite
  • High blood pressure (hypertension)
  • Skin rash
  • Headache
  • Weight loss

Toxicity

Lenvanix is generally considered very safe with few serious adverse effects. In clinical trials, the most common serious adverse effects were hypertension, diarrhea, fatigue and liver enzyme elevations.

Precautions

Patients should tell their doctor about any other medications they are taking as there may be drug interactions. This includes any supplements and over the counter medications. Patients should also inform their doctor if they are pregnant or planning to become pregnant to discuss potential risks.

Interaction

Lenvanix may interact with other medications and should not be used with certain drugs, such as antacids and calcium channel blockers. Patients should tell their doctor about any medications they are taking.

Disease Interactions

Lenvanix may interact with certain conditions and should be used with caution in those with kidney or liver disease, congestive heart failure, or a history of QT prolongation.

Drug Interactions

Lenvanix may interact with certain drugs and should not be used with certain medications, including antacids and calcium channel blockers. Patients should tell their doctor about any drugs they are taking.

Food Interactions

Lenvanix should be taken with food for optimal absorption. It is important to tell your doctor about all dietary supplements and herbs that you are taking.

Pregnancy Use

Lenvanix should not be used during pregnancy unless absolutely necessary as it can have serious side effects on the fetus. Patients should talk to their doctor about the potential risks before taking the drug during pregnancy.

Lactation Use

It is not known if lenvatinib is excreted in human milk. Patients should talk to their doctor before taking lenvatinib while breastfeeding.

Acute Overdose

The most common symptoms of an overdose include nausea, vomiting, diarrhea, fatigue, dizziness, decreased appetite, and abdominal pain. Overdose should be treated with supportive care.

Contraindication

Lenvanix is contraindicated for use in patients who are hypersensitive to the drug or components of its formulation.

Use Direction

Lenvanix should be taken orally once per day at the same time every day with or without food. It is important to take the medication exactly as prescribed by your doctor and not miss doses.

Storage Condition

Lenvanix should be stored at room temperature between 20 C - 25 C (68 F - 77 F). Keep out of reach of children.

Volume of Distribution

The apparent volume of distribution of lenvatinib is 45- 61 L.

Half Life

The biological half-life of lenvatinib is approximately 33 hours.

Clearance

The renal clearance of lenvatinib is approximately 8 L/h.

Here you find in details version of Lenvanix

Some Frequently Asked Questions About Lenvanix