Lamivudina, a brand name for a formulation containing essential Lamivudine, is widely used for various health benefits. This guide provides comprehensive information on the uses, dosage, side effects, and mechanism of action of Lamivudina, as well as insights into how long it takes to work. Understanding these aspects can help you make informed decisions about its use and effectiveness.


Lamivudina (Epivir, 3TC) is a nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and hepatitis B infections. Lamivudina is most commonly prescribed in combination with other medications.


Lamivudina is used in the treatment of HIV infection and chronic hepatitis B virus infection. It is usually prescribed in combination with other medications.

Mechanism of Action

Lamivudina works by blocking the action of reverse transcriptase, an enzyme responsible for the replication of HIV and hepatitis B viruses. By blocking this enzyme, lamivudine prevents the virus from replicating.

How Long Does it Take to Work?

It may take several weeks to several months before lamivudine reaches its full effect. Improvement in symptoms of HIV and hepatitis B may be noticed sooner, including decreased fatigue and increased appetite.


Lamivudina is rapidly and extensively absorbed, reaching almost 90% bioavailability.

Route of Elimination

Lamivudina is eliminated primarily via the urine and feces. Only about 10% of the administered dose is eliminated unchanged in the urine.

Dosage & Administration

The dose and duration of treatment with lamivudine depends on the patient’s condition and other factors. Generally, adults are prescribed a dose of 100mg taken orally twice per day or 300mg taken orally once per day. For adolescents, the dosage may be lower.
Lamivudina should be taken orally with or without food, as prescribed by your doctor. Swallow the tablets whole, do not break, crush or chew them.

Side Effects

Common side effects of lamivudine include nausea, headache, diarrhea, and abdominal pain. Rarely, more serious side effects may occur including severe allergic reaction, pancreatitis, high blood cholesterol, and headaches.


The most serious complication of lamivudine toxicity is renal failure, however this is rare. Other serious side effects include seizures, anemia, liver failure, and hypersensitivity reactions.


If you have any liver, kidney, or immune system problems, you should discuss these with your doctor before taking lamivudine. Also, if you have had an organ transplant, you may need to be monitored more closely while on this medication.


Lamivudina may interact with other medications, including antiretroviral drugs, antifungals, cholesterol-lowering medications, sedatives, and/or anticonvulsants. Be sure to mention all other medications and treatments you are currently using to your doctor before starting lamivudine.

Disease Interactions

High blood levels of lamivudine have been associated with an increased risk of lactic acidosis (buildup of lactic acid in the blood) and severe liver problems. People with kidney or liver disease, or a weakened immune system, should be monitored closely while taking lamivudine.

Drug Interactions

Lamivudina can interact with a number of medications, including antifungal medications, cholesterol-lowering medications, anticonvulsants, and sedatives. Tell your doctor and pharmacist about any other medications you are taking before starting lamivudine.

Food Interactions

It is recommended to take lamivudine with a meal or snack to improve absorption. Grapefruit juice should be avoided while on lamivudine, as it may increase the risk of side effects.

Pregnancy Use

Lamivudina is classified as a pregnancy category C medication. This means that it has not been shown to be safe in pregnant women, but the benefit may outweigh the risks. It is recommended to discuss the risks and benefits of taking lamivudine with your doctor before starting therapy.

Lactation Use

Lamivudina has been shown to be excreted into breast milk and is not recommended for women who are breastfeeding. It is recommended to discuss the risks and benefits of taking lamivudine with your doctor before starting therapy.

Acute Overdose

Acute overdose of lamivudine can cause nausea, vomiting, and diarrhea. It is recommended to seek medical treatment immediately in case of an overdose.


Lamivudina should not be taken by anyone with a known hypersensitivity to lamivudine or to any of its components. It should also be avoided in breastfeeding mothers, as it is excreted into breast milk.

Use Directions

Take lamivudine exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides. Do not take lamivudine in larger amounts or for longer than recommended.

Storage Conditions

Store lamivudine at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Volume of Distribution

The volume of distribution for lamivudine is approximately 15 liters.

Half Life

The half-life of lamivudine is approximately 6 to 12 hours.


The total clearance of lamivudine is approximately 4.2 liters/hour.

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