Kefril

Kefril, a brand name for a formulation containing essential Cefradine, is widely used for various health benefits. This guide provides comprehensive information on the uses, dosage, side effects, and mechanism of action of Kefril, as well as insights into how long it takes to work. Understanding these aspects can help you make informed decisions about its use and effectiveness.

Introduction

Kefril is an antibiotic drug commonly used for treatment of infections caused by bacteria. It is a first-generation cephalosporin and belongs to the class of cephalosporins. It is a semi-synthetic antibiotic, which means that it has been made in a laboratory from natural substances.

Uses for

Kefril is used to treat a variety of infections, including but not limited to respiratory infections, skin infections, chest infections, urinary tract infections, and some sexually transmitted diseases.

Mechanism of Action

Kefril works by inhibiting the bacteria's ability to make proteins which are an important part of its structure, function, and multiplication. By inhibiting this process, cefradine is able to kill the bacteria and prevent it from multiplying.

How Long Does it Take to Work?

Kefril usually starts to work within a few hours of taking the medication. However, depending on the type of infection being treated, it can take up to several days before the symptoms start to clear up.

Absorption

Kefril is mostly absorbed from the gastrointestinal tract, with the exception of the dose taken rectally. The majority of an oral dose is absorbed within 3 hours, with peak plasma concentrations occurring after 4-6 hours.

Route of Elimination

Kefril is eliminated largely from the urine as the unchanged form. Some is also excreted in the feces via biliary excretion. The half-life is in the range of 1-2 hours.

Dosage

Kefril is available in the form of tablets, capsules, and soluble tablets. The usual adult dosage ranges from 500mg to 1000mg twice daily, depending on the severity of the infection being treated.

Administration

Kefril should be taken orally with a glass of water, preferably one hour before or two hours after meals, or as directed by the healthcare provider. It is important not to take cefradine with food as this interferes with absorption. For rectal administration, the dose should be dissolved in a small amount of water.

Side Effect

Common side effects of cefradine include nausea, vomiting, abdominal pain, diarrhea, skin rash, oral thrush, and vaginal itching. More serious side effects include anemia, jaundice, fever, and seizures.

Toxicity

Kefril is generally safe and well tolerated at the recommended dosage. Overdose can lead to symptoms such as renal failure, seizures, and blood disorders.

Precautions

Kefril should be used with caution in patients with liver or kidney disease, and in those taking other medications such as anticoagulants, oral contraceptives, and diuretics. It should also be used with caution in pregnant and breastfeeding women.

Interactions

Kefril may interact with other drugs and should not be taken in combination with other antibiotics, sedatives, or anticoagulants. It also interacts with some herbs and supplements, including ginkgo biloba, garlic, and St. John's Wort.

Disease Interaction

Kefril has been known to interact with certain diseases, including kidney and liver disease, which may affect its effectiveness or cause side effects. It may also interact with other diseases, such as diabetes, which can alter its metabolism and increase its potential for side effects.

Drug Interactions

Kefril may interact with other drugs including anticoagulants, oral contraceptives, and diuretics. Taking cefradine simultaneously with these drugs may increase the risk of side effects. Additionally, cefradine may increase the risk of bleeding when taken with other drugs that increase blood clotting time.

Food Interactions

Kefril should be taken one hour before or two hours after meals. Taking it simultaneously with food may reduce its effectiveness. It should also not be taken with dairy products, including milk, cheese, and yogurt, as this may reduce its absorption rate.

Pregnancy Use

Kefril should be used with caution in pregnant women. There is limited evidence regarding the safety of cefradine during pregnancy. If used, the lowest effective dosage should be used for the shortest duration possible.

Lactation Use

Kefril should be avoided during lactation as it is excreted in breast milk. If it must be used, the lowest effective dosage should be used for the shortest duration possible.

Acute Overdose

If an overdose is suspected, the patient should be taken to the doctor or hospital immediately. Symptoms of an overdose include nausea, vomiting, abdominal pain, drowsiness, convulsions, and sweating.

Contraindication

Kefril is contraindicated in patients with a known hypersensitivity to cephalosporins or penicillins. It is also contraindicated in patients with severe renal or hepatic impairment, and in those who have had a previous episode of either anaphylactic or anaphylactoid reactions.

Use Direction

Kefril should always be taken as prescribed by the doctor. The dosing frequency and duration of treatment should not be altered without consulting the healthcare provider.

Storage Condition

Kefril should be stored at room temperature in a closed container, away from moisture and direct sunlight. Keep out of reach of children and pets.

Volume of Distribution

Kefril has a volume of distribution of 0.3-0.6 L/kg indicating a low penetration into tissues.

Half Life

The elimination half-life of cefradine is in the range of 1-2 hours.

Clearance

Kefril is mainly eliminated by the kidneys with an average clearance of 250mL/min.

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