Jevtana
Jevtana Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Jevtana is a brand name. Its generic name is Cabazitaxel.
Introduction
Jevtana, also known as Jevtana, is a chemotherapy drug used to treat castration-resistant prostate cancer. It is a semisynthetic neo-taxane derivative, derived from a chemical modifcation of paclitaxel.Uses
Jevtana is used to treat metastatic castration-resistant prostate cancer (mCRPC). It is typically given in combination with the hormone therapy (HT) prednisone.Mechanism of Action
Jevtana works by binding to and inhibiting the function of tubulin, a protein found in cells. This prevents cells from dividing, leading to cell death.How Long Does it Take to Work?
By inhibiting tubulin, Jevtana causes cells to die, leading to tumor shrinkage. This effect usually takes several weeks or months to manifest, and is largely dependent on the individual patient.Absorption
Jevtana is well absorbed after both intravenous (IV) and subcutaneous (SC) administration. A single IV dose of the drug results in peak plasma concentrations with about an hour, while an SC administration leads to peak plasma concentrations in two to four hours.Route of Elimination
After being absorbed into the bloodstream, Jevtana is primarily eliminated by the kidneys. It has a half-life of approximately four hours.Dosage
Jevtana is administered intravenously via infusion. The usual dose of Jevtana is 25 mg/m2 administered every 3 weeks.Administration
The drug should be infused over an hour by intravenously once every 3 weeks. It can also be given on a weekly basis or at longer intervals as deemed necessary by the health care professional. It should be given in combination with oral prednisone at a dose of 10mg daily.Side Effects
Common side effects of Jevtana include fever, chills, nausea, vomiting, fatigue, decreased appetite, constipation, diarrhea, muscle or joint pain, neuropathy, anemia, and decreased white blood cells. Other, less common side effects can also occur.Toxicity
High doses of Jevtana can cause severe toxicity. Reports of severe toxicity include decreased neurological function, abnormal heart rhythms, abnormally low blood pressure, kidney failure, and signs of cardiac distress.Precautions
Jevtana should be used with caution in patients who are at an increased risk of developing severe toxicity. These include those with preexisting kidney, heart, and neurological disorders, as well as those with a decreased blood cell count.Interactions
Jevtana may interact with other medications, including certain antibiotics, other chemotherapy drugs, and biologics. It can also interact with foods, including grapefruit and its juice.Disease Interactions
Jevtana should not be used in patients with severe liver or kidney disorders. It should also not be used in those who have previously experienced an allergic reaction to cabazitaxel or any of its components.Drug Interactions
Patients taking Jevtana should avoid taking certain other medications, including certain antibiotics, other chemotherapies, and biologics. It is important to speak with a healthcare provider before taking any new medications.Food Interactions
Patients taking Jevtana should avoid eating or drinking grapefruit and grapefruit juice. Grapefruit can affect the metabolism of the drug and can lead to an increase in Jevtana concentrations.Pregnancy Use
Jevtana is not recommended for use during pregnancy.Lactation Use
Jevtana should not be used in breastfeeding women, as it is not known whether it is excreted in breast milk.Acute Overdose
If an overdose of Jevtana is suspected, patients should seek immediate medical attention and have their vital signs monitored. Symptoms of an overdose may include seizures, confusion, dizziness, and abnormal heart rhythms.Contraindication
Jevtana is contraindicated in patients who have a known hypersensitivity to the drug or any of its components.Use Directions
Patients should consult their healthcare provider to determine the appropriate use and dose of cabazitaxel. It should be stored at room temperature and away from light.Storage Conditions
Jevtana should be stored in its original container at room temperature and away from direct light.Volume of Distribution
Jevtana has a volume of distribution of approximately 8.2 liters.Half Life
The half-life of Jevtana is approximately 3.7 hours.Clearance
Jevtana has an average clearance of approximatley 0.7 liters/hour.Here you find in details version of Jevtana
Some Frequently Asked Questions About Jevtana
https://www.medicinesfaq.com/brand/jevtana,
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https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:63584,
http://www.hmdb.ca/metabolites/HMDB0015672,
http://www.genome.jp/dbget-bin/www_bget?drug:D09755,
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=9854073,
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=99443289,
https://www.chemspider.com/Chemical-Structure.8029779.html,
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=996051,
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=63584,
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1201748,
https://zinc.docking.org/substances/ZINC000085536932,
http://www.pharmgkb.org/drug/PA165958401,
http://www.rxlist.com/jevtana-drug.htm,
https://www.drugs.com/pro/jevtana.html,
https://en.wikipedia.org/wiki/Cabazitaxel,