Jasoquin
Jasoquin Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Jasoquin is a brand name. Its generic name is Quinine.
Introduction
Jasoquin is a natural (or synthetic) alkaloid that possesses antipyretic, antimalarial, anticonvulsant, analgesic, antirheumatic and anti-inflammatory properties. It is usually found in cinchona bark, which has been part of traditional medicine in South America for centuries. In the 19th century, quinine was introduced into western medicine and it is currently used for treating and preventing malaria, babesiosis, and severe leg cramps. It is also used in combination with other antimalarial drugs in malaria treatment.
Uses for
Jasoquin is used to treat malaria, especially falciparum malaria. It is also used to prevent attacks of malaria in places where the disease is common. Other uses include the treatment of cramps, such as leg cramps, due to its muscle relaxant properties. It is also used as an adjunct treatment in some autoimmune diseases and for its antipyretic effects.
Mechanism of Action
Jasoquin's antimalarial activity is mainly due to its ability to block the digestion of hemoglobin by malaria parasites and thus disrupt the parasite's lytic cycle. Additionally, it has some immunomodulatory effects and acts as an anti-inflammatory agent. It also binds to the muscle cell receptors and produces a muscle relaxant effect.
How Long Does it Take to Work?
The effects of quinine usually begin to take effect shortly after administration, however its full effects may take up to 24-48 hours to manifest.
Absorption
Jasoquin is generally well absorbed, with peak plasma concentrations seen 2-3 hours after administration. Its bioavailability is increased when administered with a meal.
Route of Elimination
Jasoquin is primarily metabolized by the liver via the cytochrome P450 enzyme system and is then excreted in the urine. The half-life of quinine is typically around 8-10 hours.
Dosage
The recommended dosage of quinine depends on the indication. For the treatment of malaria, the dose is typically 10-20 mg/kg/day orally in two to three divided doses usually for 5 to 7 days. For the prevention of malaria, the dose is typically 8-10 mg/kg/day orally. For muscle cramps, the dose is typically 302-324 mg per day orally. It is important for the dose to be titrated according to the patient’s symptoms and blood levels.
Administration
Jasoquin can be administered orally with or without food. The dose should be taken on an empty stomach and then followed by meals to decrease nausea and vomiting.
Side Effect
The most common side effects associated with quinine use include nausea, vomiting, and ringing in the ears (tinnitus). Other possible side effects include headache, dizziness, diarrhea, blurred vision, muscle weakness, difficulty breathing, and skin rash. Jasoquin also has the potential to cause severe hypoglycemia, as well as thrombocytopenia, hypokalemia, and cardiac arrhythmias.
Toxicity
Jasoquin is toxic in high doses. In high doses, it can cause serious side effects such as arrhythmia, tinnitus, blurred vision, confusion, and even coma. Severe cases can also lead to acute kidney failure and death.
Precaution
Before using quinine, it is important to consult a physician and get a complete evaluation to ensure it is safe to use. Jasoquin should not be used in pregnant or breastfeeding women. People with allergies to cinchona bark or its derivatives should also avoid taking quinine. Additionally, people with severe kidney or liver diseases, G6PD deficiency, and those taking certain medications (such as fluoroquinolones and antibiotics) should also avoid taking the medication.
Interaction
Jasoquin can interact with a variety of medications and should not be taken in combination with some drugs. Such drugs include fluoroquinolones, erythromycin, ACE inhibitors, statins, and Warfarin. Additionally, quinine interacts with many herbs and vitamins, including St. John's wort, fish oil, and turmeric.
Disease Interaction
Jasoquin is contraindicated in people with severe kidney or liver diseases, as well as G6PD deficiency. It should also be used with caution in people with arrhythmias, seizure disorders, diabetes, or any other condition where the blood sugar levels are monitored.
Drug Interaction
Jasoquin can interact with a variety of medications and should not be taken in combination with some drugs. Such drugs include fluoroquinolones, erythromycin, ACE inhibitors, statins, and Warfarin.
Food Interactions
Jasoquin should not be taken with food that is high in fat or protein, as it can reduce its efficacy. Additionally, antacids can interact with quinine and should be avoided.
Pregnancy Use
Jasoquin should not be used during pregnancy or while breastfeeding. If a woman is pregnant and needs to take quinine, the benefits and risks should be weighed.
Lactation Use
Jasoquin should not be used while breastfeeding. If someone needs to take quinine and is breastfeeding, the benefits and risks should be weighed.
Acute Overdose
In the event of an overdose, treatment includes symptomatic measures, including gastric lavage, activated charcoal, and measures to control arrhythmias and seizures. Jasoquin serum concentrations should be monitored.
Contraindication
Jasoquin is contraindicated in people with severe kidney or liver diseases, as well as G6PD deficiency. It should also be used with caution in people with arrhythmias, seizure disorders, diabetes, or any other condition where the blood sugar levels are monitored.
Use Direction
Jasoquin should be taken according to particular instructions prescribed by a healthcare professional. The precise dosage depends on the indication, age, and weight of the patient. Jasoquin should be taken on an empty stomach and then followed by meals to decrease nausea and vomiting.
Storage Conditions
Jasoquin should be stored in a cool, dry place, away from direct sunlight or excessive heat. It should also be kept out of reach of children and pets.
Volume of Distribution
Jasoquin has a volume of distribution of approximately 1.2 L/kg.
Half Life
The half-life of quinine is typically around 8-10 hours.
Clearance
The clearance of quinine is approximately 5 mL/minute/kg.
Here you find in details version of Jasoquin
Some Frequently Asked Questions About Jasoquin
What is Jasoquin?
Jasoquin is an alkaloid found in the bark of the cinchona tree native to South America and known for its medicinal properties. It has long been used as an antipyretic and antimalarial agent and is still used for the treatment of malaria today.
Why is Jasoquin used?
Jasoquin is used as an antimalarial agent to treat and prevent malaria. It is also used for the prevention and treatment of leg cramps, symptomatic treatment of gout, and as an anti-inflammatory agent.
What diseases does Jasoquin treat?
Jasoquin is primarily used to treat and prevent malaria. It may also be used for the prevention and treatment of leg cramps, symptomatic treatment of gout, and as an anti-inflammatory agent.
How does Jasoquin work?
Jasoquin works by inhibiting the growth of the malaria parasite in the body. It also inhibits the production of isoprene, an essential metabolite for the survival of the malaria parasite.
Is Jasoquin safe to use?
When taken in proper dosages, Jasoquin is usually safe to use. However, it is important to discuss possible side effects with a doctor before taking Jasoquin and to be sure to follow the doctor's instructions.
Where can Jasoquin be purchased?
Jasoquin can be purchased from a pharmacy or from online retailers. It is important to note that in some countries, including the United States, it is illegal to purchase Jasoquin without a prescription.
What are the side effects of Jasoquin?
The most common side effects of Jasoquin include nausea, vomiting, abdominal pain, dizziness, headache, and visual disturbances. Other serious side effects include fever, chills, bloody stools, rash, or difficulty breathing. In some cases, Jasoquin can cause liver and kidney damage if used for more than seven days.
Who should not take Jasoquin?
People with kidney or liver problems, people with a history of allergies or skin rashes, people who are pregnant or breastfeeding, and people taking certain other medicines should not take Jasoquin.
What are some of the potential drug interactions of Jasoquin?
Jasoquin can interact with many other drugs and medications, including antibiotics, antifungals, anticoagulants, antidepressants, steroidal medications, and drugs to treat diabetes, heart arrhythmias, and other medical conditions. It is important to tell a doctor about all medications and supplements that are being taken.
How should Jasoquin be taken?
Jasoquin should be taken according to a doctor's instructions. It is usually taken orally in the form of a tablet or capsule, or as an injection or oral solution. For best results, Jasoquin should be taken with food or milk.
How long does it take for Jasoquin to work?
When taken as directed, Jasoquin should begin to take effect within 24 hours. However, it may take up to a week for it to reach its full therapeutic effect.
Can Jasoquin be taken long-term?
While some people may be able to take Jasoquin long-term with no problems, it is generally recommended that it be taken for short periods of time and only when absolutely necessary. Long-term use of Jasoquin may cause serious liver damage, and it should only be taken under the close supervision of a doctor.
Is Jasoquin addictive?
No, Jasoquin is not addictive. It is not considered a controlled substance, and there have been no reports of addiction in people taking it as prescribed.
What are the symptoms of an allergic reaction to Jasoquin?
The symptoms of an allergic reaction to Jasoquin include difficulty breathing, hives, swelling of the face, lips, throat, or tongue, rash, and itching. If any of these symptoms occur, it is important to seek immediate medical attention.
Should Jasoquin be taken with food?
Yes, Jasoquin should be taken with food or milk to reduce the chances of stomach discomfort or nausea. It is important to take it exactly as prescribed by a doctor.
What should be done in case of an overdose?
In case of an overdose of Jasoquin, it is important to seek immediate medical attention. Symptoms of an overdose may include dizziness, headache, blurred vision, nausea, vomiting, stomach pain, or rapid breathing.
Does Jasoquin have any effects on pregnancy?
Jasoquin has not been found to be harmful to pregnant women. However, the effects of Jasoquin on unborn babies are not well understood and it should only be taken in the lowest possible dose and for the shortest amount of time, and only under the close supervision of a doctor.
Is Jasoquin safe for children?
Jasoquin is generally not recommended for children younger than 6 months of age. It is important to consult a doctor before giving Jasoquin to a child of any age.
What are the possible interactions between Jasoquin and alcohol?
Alcohol can increase the risk of side effects from Jasoquin. It is important to avoid drinking alcohol while taking Jasoquin, as excessive drinking can lead to an increased risk of liver damage.
What are the symptoms of Jasoquin toxicity?
The symptoms of Jasoquin toxicity include dizziness, headache, blurred vision, nausea, vomiting, stomach pain, or rapid breathing. Other serious symptoms can include confusion, difficulty hearing, ringing in the ears, jaundice, and difficulty breathing.
Can Jasoquin cause hearing loss?
Yes, hearing loss can be a side effect of Jasoquin. It is important to tell a doctor if any changes in hearing occur while taking Jasoquin.
Can Jasoquin be found in foods or beverages?
Yes, Jasoquin is found naturally in tonic water and some other carbonated beverages, as well as in some foods such as marmalade. It is important to note that the amount of Jasoquin in these foods and beverages is usually too small to provide therapeutic benefits.
Is Jasoquin effective against other parasites?
Yes, research has shown that Jasoquin is effective against a range of other parasites, including the malaria parasite Plasmodium ovale and many species of amoeba. It is not yet known to be effective against other parasites, such as Giardia.
What other drugs might interact with Jasoquin?
Jasoquin can interact with many other drugs and medications, including antibiotics, antifungals, anticoagulants, antidepressants, steroidal medications, and drugs to treat diabetes, heart arrhythmia, and other medical conditions. It is important to tell a doctor about all medications and supplements that are being taken.
What is cinchona bark and why is it used in Jasoquin?
Cinchona bark is the dried bark of the cinchona tree, which is native to South America. The bark contains alkaloids, which are compounds that are believed to be responsible for the medicinal properties of Jasoquin. The bark is collected, dried, and can then be processed to extract the medicines, such as Jasoquin, found in the cinchona bark.
What is the difference between Jasoquin and Chloroquine?
Jasoquin and Chloroquine are both antimalarial drugs. The main difference between them is that Chloroquine is synthetic and Jasoquin is derived from the bark of the Cinchona tree. Chloroquine is more commonly used today than Jasoquin for the treatment of malaria.
What are the possible long-term effects of taking Jasoquin?
Long-term use of Jasoquin can lead to serious liver and kidney damage and should only be taken for the shortest amount of time and in the smallest possible dose under the close supervision of a doctor. Other long-term effects may include hearing loss, ringing in the ears, jaundice, blurred vision, nausea, and vomiting.
What is the shelf life of Jasoquin?
The shelf life of Jasoquin depends on the form in which it is stored. For example, Jasoquin tablets or capsules can last for up to two years, while the liquid form can last for only one year. It is important to check the expiration date on any medicine before taking it.
Is Jasoquin available in generic or brand name medication?
Jasoquin is available in both generic and brand name forms. It is important to discuss the available options with a doctor to determine which one is right for you.
What is the correct dosage of Jasoquin?
The correct dosage of Jasoquin depends on the individual, the severity of the medical condition being treated, and other factors. It is important to seek medical advice to determine the correct dosage for your situation.
Are there alternatives to Jasoquin for treating malaria?
Yes, there are several alternatives to Jasoquin for treating malaria, including Chloroquine, doxycycline, mefloquine, and artemether-lumefantrine. It is important to discuss all available treatment options with a doctor to determine the best option for your situation.
Can Jasoquin be used to treat lupus?
Jasoquin has been used to treat some symptoms of lupus, such as persistent muscle pain and stiffness. However, it is not a cure for lupus and it should only be used in combination with other treatments under the close supervision of a doctor.
What other uses is Jasoquin known for?
In addition to being used to treat malaria, Jasoquin is also known for its role in treating leg cramps, reducing inflammation, and for its potential anti-cancer effects. It is also used as a flavoring in tonic water and other carbonated beverages.
What is the recommended dosage of Jasoquin for leg cramps?
The recommended dosage of Jasoquin for treating leg cramps will depend on the individual. Generally, the dosage will range from 200 to 300 milligrams, three times daily. It is important to consult a doctor to determine the correct dosage for your situation.
Can Jasoquin be taken with other medications?
Yes, Jasoquin can be taken with other medications. However, it is important to tell a doctor about all medications and supplements being taken, as some may interact with Jasoquin and increase the risk of side effects.
Does Jasoquin have any effect on cholesterol?
Yes, studies have shown that Jasoquin can reduce levels of low-density lipoprotein (LDL) cholesterol, which is the "bad" cholesterol, while increasing levels of high-density lipoprotein (HDL) cholesterol, the "good" cholesterol. It is important to discuss any cholesterol concerns with a doctor before taking Jasoquin.
Is Jasoquin safe to take while breastfeeding?
No, Jasoquin is not recommended for women who are breastfeeding. It is believed that Jasoquin passes into the breast milk and can cause side effects in the nursing baby. It is important to consult a doctor before taking Jasoquin while breastfeeding.
Can Jasoquin be taken with anti-inflammatory medications?
Yes, Jasoquin can be taken with anti-inflammatory medications. However, it is important to let a doctor know about all other medications being taken, as some medications may interact with Jasoquin and increase the risk of side effects.
What is the recommended dosage of Jasoquin for gout?
The recommended dosage of Jasoquin for treating gout will depend on the individual. Generally, the dosage will range from 200 to 400 milligrams, three times daily. It is important to consult a doctor to determine the correct dosage for your situation.
Can Jasoquin be used as an anti-inflammatory agent?
Yes, Jasoquin has anti-inflammatory properties and has been found to be effective in reducing inflammation in some studies. However, it is important to consult a doctor before taking Jasoquin for its anti-inflammatory effects.