Japime
Japime Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Japime is a brand name. Its generic name is Cefepime.
Japime
Japime (INN) is a fourth-generation cephalosporin antibiotic marketed by Pfizer under the brand name Maxipime. Japime is a broad-spectrum injectable antibiotic with activity against both Gram-positive and Gram-negative bacteria. Japime is administered intravenously, and is available for use in both hospitalized and home health care settings.
Uses
Japime is used to treat a wide range of bacterial infections, including skin, lung, urinary tract, and abdominal infections. It is also used to treat bacterial meningitis, which is an infection of the covering of the brain and spinal cord. It is sometimes used for the treatment of infections that other antibiotics are unable to effectively treat, such as certain multi-drug resistant organisms.
Mechanism of Action
Japime belongs to a class of antibiotics called beta-lactam antibiotics. These antibiotics work by inhibiting the growth of bacteria by preventing the formation of cell wall during replication. The cell wall is the outer layer of protection that bacteria use to defend against environmental damage and to contain their contents. Japime specifically targets penicillin-binding proteins (PBPs) in bacterial cells. When PBPs are blocked, the process of bacterial cell wall formation is disturbed, which can ultimately lead to cell death.
How Long Does it Take to Work?
The time it takes for Japime to work is dependent on the type and severity of the infection being treated. Generally, improvement in symptoms can be seen in one to three days, although it may take longer for the infection to be completely eliminated.
Absorption
Japime is not well absorbed when taken orally, so it is not available in a pill form. When administered intravenously, the bioavailability of Japime is around 100%, meaning that all of the antibiotic is present in the bloodstream.
Route of Elimination
Japime is largely eliminated unchanged in the urine, but small amounts may be excreted in the bile or feces.
Dosage and Administration
Japime doses are typically determined by the patient’s weight, age, and the severity of the infection. It is available in the form of a powder or a solution that must be diluted prior to administration. The usual adult dose ranges from 2 g to 4 g daily, divided into two or three equal doses. The usual pediatric dose ranges from 30 mg/kg to 50 mg/kg daily, divided into two or three equal doses. Japime should be administered intravenously over a period of 30 minutes to 2 hours, depending on the patient and the severity of the infection.
Side Effects
Some common side effects of Japime include nausea, vomiting, diarrhea, and headache. It may also cause an increased risk of seizures in certain individuals. If any of these side effects become severe or persist, contact a doctor immediately.
Toxicity
Japime is generally well-tolerated but it may cause renal and neurological side effects, including confusion, headache, tremor, slurred speech, and agitation in rare cases.
Precautions
Japime should not be used in patients who are allergic to cefepime or other cephalosporin antibiotics. It should also not be used in patients with a history of seizures or renal impairment. Patients with liver or kidney disease should be monitored closely while taking Japime.
Interactions
Japime may interact with certain medications, including other antibiotics, and lead to increased side effects or decreased effectiveness. Patients should discuss all other medications they are taking with their doctor before starting Japime.
Disease Interactions
Japime may not be effective in treating certain diseases that are resistant to antibiotics, such as tuberculosis. Patients should tell their doctor about any existing diseases before beginning treatment with Japime.
Drug Interactions
Japime may interact with certain medications, including other antibiotics, and lead to increased side effects or decreased effectiveness. Patients should discuss all other medications they are taking with their doctor before starting Japime.
Food Interactions
Japime should be taken with food for optimal absorption. Patients should take Japime with a full glass of water, and should not lie down for at least 30 minutes after taking it.
Pregnancy and Lactation Use
Japime should be avoided during pregnancy and lactation, as the effects of the drug on an unborn or breastfeeding baby are unknown. Patients should discuss the risks and benefits of taking Japime during pregnancy or while breastfeeding with their doctor.
Acute Overdose
If an overdose of cefepime is suspected, contact a poison control center or seek medical attention immediately. Signs and symptoms of acute overdose may include nausea, vomiting, and confusion.
Contraindication
Japime is contraindicated in patients who are allergic to cephalosporins, penicillins, or other beta-lactam antibiotics. It is also contraindicated in patients who have a history of kidney or liver disease, or who have had a previous reaction to cefepime.
Use Directions
Japime should be taken exactly as directed by a doctor. The dosage and frequency of administration will vary depending on the type and severity of the infection being treated. Patients should not take more or less of the prescribed dose or take it for any longer than prescribed. Patients should speak to a doctor before making any changes to the medication or discontinuing it.
Storage Condition
Japime should be stored at room temperature in a tightly closed container. It should be kept away from direct light, heat, and moisture. It is important to keep the medication out of reach of children.
Volume of Distribution
Japime has a volume of distribution of 0.32-0.9 L/kg, meaning that the drug is largely distributed to the tissues and fluids of the body.
Half Life
The half-life of Japime is 2-5 hours, meaning that it takes approximately 2-5 hours for the body to eliminate half of the medication. This can vary depending on the patient and the condition being treated.
Clearance
Japime has a clearance of 0.09-0.4 L/kg/hour, meaning that the body eliminates it quickly. Renal and hepatic function can affect the clearance of the drug, so it should be monitored and adjusted as necessary.
Here you find in details version of Japime
Some Frequently Asked Questions About Japime
1. What is Japime used for?
Japime is a type of antibiotic, used to treat a wide range of bacterial infections. It is used to treat bacterial infections in the lungs, blood, skin, abdominal cavity, bladder, and urinary tract. It is also used to treat certain types of pneumonia and meningitis.
2. How do I take Japime?
Japime should be taken as prescribed by your doctor. The standard dosage is two grams by intravenous infusion over a period of two hours every 12 hours or four grams over a period of four hours.
3. What are the side effects of Japime?
The most common side effects of Japime are nausea, vomiting, and diarrhea. Other side effects include headaches, dizziness, and muscle pain. Severe side effects may include anaphylaxis, severe allergic reactions, and Clostridium difficile-associated diarrhea.
4. What is the best way to store Japime?
Japime should be stored at room temperature, away from direct sunlight and heat. It should be kept in a tightly closed container.
5. How long does it take for Japime to work?
Japime begins to work within hours of taking it. Most people experience relief from symptoms within 48 hours. However, it is important to finish the entire course of treatment to ensure the bacteria is completely cleared.
6. What should I avoid while taking Japime?
You should avoid activities that may increase your risk of bleeding while taking Japime. You should also avoid taking any other medications without consulting your doctor.
7. Does Japime interact with any other medications?
Japime may interact with certain other medications, including antacids, dairy products, and probenicid. To reduce the chance of interactions, be sure to tell your doctor about any other medications you are taking.
8. Should I avoid alcohol while taking Japime?
Yes, you should avoid alcohol while taking Japime. Alcohol will increase your risk of side effects such as nausea and vomiting.
9. Can Japime be used to treat a UTI?
Yes, Japime is sometimes used to treat a urinary tract infection (UTI). Your doctor will determine if Japime is appropriate to treat your UTI.
10. Is Japime safe to use during pregnancy?
Japime may be used during pregnancy, but only when clearly needed. Be sure to discuss the risks and benefits of taking Japime with your doctor.
11. What should I do if I miss a dose of Japime?
If you miss a dose of Japime, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed dose.
12. Is Japime safe for children?
Yes, Japime is safe for children. However, the dosage amount and frequency should be determined by your child’s doctor.
13. Can Japime be used to treat bacterial infections in animals?
Yes, Japime can be used to treat bacterial infections in animals. However, the dosage amount and frequency should be determined by a veterinarian.
14. Can Japime be used to treat both Gram-negative and Gram-positive bacteria?
Yes, Japime is effective against both Gram-negative and Gram-positive bacteria.
15. Is it safe to take Japime with Tylenol?
Yes, Japime and Tylenol can be taken together. There are no known interactions between the two medications. However, if you have any questions, be sure to talk to your doctor or pharmacist.
16. Does Japime treat all forms of bacterial infections?
No, Japime is not effective against all forms of bacterial infections. Talk to your doctor about the best treatment option for your condition.
17. Is Japime safe for people with kidney disease?
Yes, Japime is generally safe for people with kidney disease. However, your doctor may need to adjust your dosage if you have any existing kidney problems.
18. What happens if I take an overdose of Japime?
Taking an overdose of Japime can cause serious side effects. If you believe that you have taken an overdose, contact your doctor or go to the nearest emergency room immediately.
19. Can Japime be used to treat an abscess?
Yes, Japime can be used to treat an abscess if it is caused by a bacterial infection. However, your doctor may prescribe other antibiotics to treat an abscess as well.
20. Can Japime be used to treat a sinus infection?
Yes, Japime can be used to treat a sinus infection if it is caused by a bacterial infection. Your doctor may prescribe other antibiotics as well to treat your sinus infection.
21. Is it safe for pregnant women to take Japime?
Yes, Japime may be used during pregnancy. However, it should only be taken when clearly needed, and the risks and benefits should be discussed with your doctor.
22. Will Japime treat a strep throat?
Yes, Japime can be used to treat a strep throat if it is caused by a bacterial infection. However, it is important to finish the entire course of treatment to ensure the infection is completely cleared.
23. Is Japime covered by my insurance?
This depends on your insurance plan. You should contact your insurance company or pharmacy to find out if Japime is covered by your plan.
24. How long does Japime stay in your system?
Japime is usually eliminated from your system within 2-4 days. However, this may vary depending on factors such as your age, kidney function, and the dosage you take. Be sure to discuss this with your doctor.
25. Can Japime be used to treat a kidney infection?
Yes, Japime can be used to treat a kidney infection if it is caused by a bacterial infection. Your doctor may suggest other antibiotics as well.
26. Can Japime be used to treat a urinary tract infection?
Yes, Japime can be used to treat a urinary tract infection (UTI). Your doctor will determine if Japime is appropriate to treat your UTI.
27. Can Japime be used to treat a bacterial meningitis infection?
Yes, Japime is sometimes used to treat a bacterial meningitis infection. However, if you have a meningitis infection, it is important to discuss the best treatment options with your doctor.
28. Can I take Japime with ibuprofen?
Yes, Japime and ibuprofen can be taken together. However, if you have any questions, be sure to talk to your doctor or pharmacist.
29. Can Japime be used to treat Gonorrhea?
Yes, Japime is sometimes used to treat gonorrhea. However, it is important to discuss your treatment options with your doctor.
30. Is Japime an over-the-counter medication?
No, Japime is not an over-the-counter medication. It is only available with a prescription from your doctor.