By Incepta Pharmaceuticals Limited
Weight: 80 mg/2 ml
Unit Price: 14
Last Updated: 2019-09-03 08:36:36
Gentamicin is indicated in the following conditions:
Gentamicin is the most important of the aminoglycosides and is widely used for the treatment of serious infections. It is bactericidal and active against some Gram-positive and many Gram-negative organisms. It is active against Pseudomonas aeruginosa, Proteus sp. E. coli, Klebsiella-Enterobacter-Serratia sp. Citrobacter sp. and Staphylococcus sp. Gentamicin interferes with bacterial protein synthesis by binding to 30S and 50S ribosomal subunits resulting in a defective bacterial cell membrane.
The daily dose is 2-5 mg/kg in divided doses every 8 hours. The standard adult dose is 100 ml to be administered over 20 minutes, 8 hourly or as prescribed by the physician. Whenever possible treatment should not exceed 7 days. Higher doses are occasionally indicated for serious infections, especially in the neonates or the compromised hosts. The interval between doses and even the dose itself may be modified if there is impairment of renal function or high pre-dose plasma concentration (pre-dose 'trough' concentration should be less than 2 mg/L).
Vestibular and auditory damage, nephrotoxicity, rarely hypomagnesaemia on prolonged therapy, pseudomembranous colitis, neuromuscular blockade, blood dyscrasia.
In renal impaired patients, infants and elderly adjust dose and monitor renal, auditory and vestibular functions together with plasma Gentamicin concentration. Plasma concentration monitoring avoids both excessive and sub-therapeutic concentrations thus preventing toxicity and ensuring efficacy. Avoid prolonged use.Infusion of fluid should immediately be discontinued if rigor arises from any reason during the process. Do not use if the solution is cloudy, contains particles or after expiry date.
Aminoglycosides should not be given with potentially ototoxic diuretics (e.g. frusemide and ethacrynic acid). Concurrent use of other nephrotoxic drugs including other aminoglycosides, vancomycin and some of the cephalosporins may increase the risk of toxicity. Care is also required if other drugs with a neuromuscular blocking action are given concomitantly.
Hypersensitivity to Gentamicin, pregnancy, myasthenia gravis.
The intravenous administration of Gentamicin may be particularly useful for treating patients with bacterial septicemia or those in shock. It may also be the preferred route of administration for some patients with congestive heart failure, hematologic disorders, severe burns or those with reduced muscle mass.
Gentamicin should be stored at controlled room temperature and protected from light. This intravenous infusion is not intended for multi-dose use.