Insul Lispro

Insul Lispro Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Insul Lispro is a brand name. Its generic name is Insulin Lispro.

Insul Lispro

Insul Lispro is a fast-acting insulin analog used to control high blood sugar in patients with diabetes mellitus. It helps to lower blood sugar levels by enabling glucose to enter the cells of the body and be used for energy.

Introduction

Insulin lispro is a human insulin analogue produced by recombinant DNA technology. It is composed of a peptide sequence of A21-B30-A20. It is an 'insulin secretagogue' which accelerates the release of endogenous insulin from beta cells of the pancreas. It may also have a role in preventing diabetes and improving glycaemic control in existing diabetes patients.

Uses for

• To control high blood sugar levels in type 1 and type 2 diabetes mellitus (DM).
• To reduce glucose levels in diabetic ketoacidosis (buildup of ketones in the blood due to lack of insulin) and hyperosmolar hyperglycemic state (HHS, high level of sugar in the blood due to inadequate production of insulin).
• To reduce the risk of major cardiovascular events such as stroke, heart attack, and death from cardiovascular disease in adults with type 2 diabetes who are having difficulty controlling their blood sugar levels with other medications.

Mechanism of action

Insulin lispro binds to insulin receptors on the surface of cells, activating the enzyme adenyl cyclase and phosphoinositide 2-kinase, which increases intracellular levels of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). These peptides promote insulin secretion from pancreatic beta cells, which then passes into the bloodstream and helps to regulate blood glucose levels.

How long does it take to work?

Insulin lispro starts to work within minutes of injection and can last up to 8 hours. It typically starts to reduce elevated blood glucose levels with 30 minutes of administration.

Absorption

Insulin lispro is rapidly absorbed after subcutaneous injection, reaching peak levels within 30-90 minutes depending on the site of injection. After absorption, insulin lispro is distributed throughout the body, reaching its target tissues to promote the transport of glucose into the cells.

Route of elimination

Insulin lispro is broken down by the body and eliminated through the kidneys. A small amount is also excreted by the gut.

Dosage

The dose of insulin lispro depends on the individual's blood glucose level, age, sex, and other conditions such as kidney or liver disease. It is usually given as a single subcutaneous injection and can be repeated once every 8 hours if necessary.

Administration

Insulin lispro is usually administered by subcutaneous injection. It can be injected into the abdomen, thigh, or upper arm. If an insulin pen is used, vary the injection site to avoid tissue damage.

Side Effect

Insulin lispro usually causes few side effects with low risk of severe hypoglycemia (low blood sugar). However, some people may experience mild side effects such as nausea, headache, blurred vision, or skin rash. If any of these side effects occur, contact your doctor.

Toxicity

Insulin lispro is not toxic. However, taking too much may cause low blood sugar (hypoglycemia), which can lead to severe health problems. Signs of hypoglycemia include confusion, feeling shaky, dizziness, sweating, and difficulty concentrating.

Precautions

• Insulin lispro should not be given to people with a known hypersensitivity or allergy to any of its ingredients.
• Before taking insulin lispro, tell your doctor if you are pregnant or breastfeeding.
• Insulin lispro can cause low blood sugar, which can lead to serious health problems if not treated promptly. Monitor your blood sugar levels regularly and take the necessary steps to manage sudden drops in blood sugar levels.
• Tell your doctor if you have any other medical conditions, are taking any other medications, and/or if you are drinking alcohol.

Interactions

Insulin lispro should not be taken with certain medications, including certain antibiotics, anti-fungals, and medications for HIV/AIDS. In addition, certain medications such as birth control pills, steroids, and over-the-counter medications may interact with insulin lispro and should not be taken at the same time.

Disease interaction

Insulin lispro may enhance the effects of some medications used in the treatment of diabetes such as sulfonylureas and thiazolidinediones. High doses of insulin lispro may also increase the risk of hypoglycemia (low blood sugar).

Drug interaction

Drugs that may interact with insulin lispro include certain beta blockers, non-steroidal anti-inflammatory drugs (NSAIDs), and antipsychotics. Drugs that may decrease blood sugar levels such as ACE inhibitors, angiotensin II receptor blockers, and diuretics should be used with caution.

Food interactions

Insulin lispro should be taken with food, as this helps to reduce the risk of hypoglycemia. Eating a meal high in carbohydrates and/or fat before taking insulin lispro may also help to reduce the risk of this side effect.

Pregnancy Use

Insulin lispro is not recommended during pregnancy, as it has not been studied in pregnant women. Women who are planning to become pregnant should discuss this with their doctor before taking insulin lispro.

Lactation Use

Insulin lispro is not recommended for use while breastfeeding, as it is unknown if it passes into breast milk. Women who are breastfeeding should discuss this with their doctor before taking insulin lispro.

Acute Overdose

An acute overdose of insulin lispro may cause hypotension, coma, and even death. Prompt medical attention and monitoring of blood sugar levels is necessary in case of an overdose.

Contraindication

Insulin lispro is not recommended for use in individuals with hypersensitivity or allergy to its ingredients. It is also not recommended for use in individuals with active malignancy, and those with diabetic ketoacidosis or diabetic coma.

Use Direction

To use insulin lispro, inject the prescribed dose into the skin, preferably the abdomen, following the instructions of your doctor or nurse. Do not inject into a muscle. Change the injection sites to avoid tissue damage.

Storage Condition

Insulin lispro should be stored in its original packaging at room temperature (between 15-30°C). It should be protected from light, moisture, and excessive heat. It should not be frozen or refrigerated.

Volume of Distribution

Insulin lispro is rapidly distributed throughout the body and reaches its target tissues to promote glucose absorption into the cells. In most cases, the drug is completely Babsorbed within 30-90 minutes of injection.

Half Life

The half-life of insulin lispro is 5-8 hours, although it may be shorter depending on the dose and route of administration.

Clearance

Insulin lispro is rapidly cleared from the body and eliminated by the kidneys. A small amount is also excreted by the gut.

Dosage Information

• Usual starting dose is 0.2-0.3 Units/kg/day, given in divided doses. Dosage may be increased according to patient’s needs and as guided by glucose levels.
• If taken orally, dosage of 4-10 Units two to four times a day is suggested.
• Injectable insulin lispro is to be injected subcutaneously and is available in 100 units/mL or 200 units/mL formulations. Usual dose is 0.3-1 Unit/kg/day, divided into two to four doses.
• For diabetes ketoacidosis, usual dose is 0.1 unit/ kg/hour, with 2-4 times daily insulin injections.

Here you find in details version of Insul Lispro

Some Frequently Asked Questions About Insul Lispro

What is insulin lispro?

Insulin lispro is a rapid-acting, man-made form of insulin used to improve glycemic control in adults and children with diabetes mellitus.

How does insulin lispro work?

Insulin lispro works by lowering the amount of sugar (glucose) in the blood, by helping move glucose from the blood into the cells where it can be used for energy and help reduce blood sugar levels.

Is insulin lispro a human insulin?

No. Insulin lispro is a man-made form of insulin that differs slightly from human insulin.

What are the side effects of insulin lispro?

Common side effects include low blood sugar (hypoglycemia), injection site reactions, and weight gain. More serious side effects include skin thickening or pits at the injection sites, and in some cases, serious allergic reactions.

How is insulin lispro stored?

Insulin lispro should be stored in the refrigerator. Do not freeze. Keep the vial away from heat and light and out of direct sunlight.

What is the difference between regular insulin and insulin lispro?

Insulin lispro is a rapid-acting insulin that works quickly to lower blood sugar levels. Regular insulin is a longer-acting insulin that takes longer to take effect.

Who should not take insulin lispro?

People with type 1 diabetes should not take insulin lispro. People with type 2 diabetes who take medications to lower their blood sugar levels should also not take insulin lispro.

Is insulin lispro safe to use during pregnancy?

Yes, insulin lispro can be used safely during pregnancy. However, your doctor may prescribe a different type of insulin depending on your individual needs.

Can you take other medications while taking insulin lispro?

Yes, you can take other medications while taking insulin lispro. It is important to tell your doctor about all the medications and supplements you are taking.

How long does it take for insulin lispro to start working?

Insulin lispro typically starts working within 15 minutes to 1 hour after injection.

How long does insulin lispro last?

Insulin lispro typically lasts 3-4 hours.

Are there any foods that should be avoided when taking insulin lispro?

It is important to maintain a balanced diet when taking insulin lispro. Avoiding foods high in fat, sugar, and refined carbohydrates can help control blood sugar levels.

What is the recommended dosage of insulin lispro?

The recommended dosage of insulin lispro varies from person to person, and is based on a number of factors including age, weight, activity level, diet, and other medications that are being taken. Your doctor or healthcare provider can help determine the best dosage for you.

What are the signs of low blood sugar while taking insulin lispro?

Signs of low blood sugar (hypoglycemia) while taking insulin lispro include dizziness, confusion, shakiness, sweating, hunger, blurred vision, and fatigue.

How can hypoglycemia be avoided while taking insulin lispro?

Some strategies to help avoid hypoglycemia while taking insulin lispro include eating regular meals and snacks, monitoring blood glucose levels regularly, and avoiding exercise on an empty stomach.

Can insulin lispro be taken with other diabetes medications?

Yes, insulin lispro can be taken with other diabetes medications. However, always talk to your doctor or healthcare provider first before taking any additional medications.

Can insulin lispro be taken while breastfeeding?

Yes, insulin lispro is safe to take while breastfeeding. However, always talk to your doctor or healthcare provider first before taking any medication while breastfeeding.

When should insulin lispro be taken?

It is important to follow the instructions given by your doctor or healthcare provider for taking insulin lispro. Generally, it is recommended to take it shortly before a meal or immediately after a meal.

What should I do if I miss a dose of insulin lispro?

If you miss a dose of insulin lispro, contact your doctor or healthcare provider to discuss the best plan for making up the missed dose.

What happens if I take too much insulin lispro?

Taking too much insulin lispro can cause low blood sugar (hypoglycemia). If this occurs, seek immediate medical attention.

Does insulin lispro cause weight gain?

Yes, insulin lispro can cause weight gain. This is due to the fact that insulin helps the body process sugar more effectively, leading to increased absorption of carbohydrates and sugar, which can result in weight gain.

What should I do if I have an allergic reaction to insulin lispro?

If you experience a severe allergic reaction after taking insulin lispro, seek immediate medical attention.

Is insulin lispro available in generic form?

No, insulin lispro is not available in generic form.

Can children take insulin lispro?

Yes, insulin lispro is approved for use in children as young as 4 years old.

Can insulin lispro be given subcutaneously?

Yes, insulin lispro can be given subcutaneously, which means it is injected into the fatty tissue just below the skin.

Does insulin lispro cause drowsiness?

No, insulin lispro does not generally cause drowsiness.

What is the best way to inject insulin lispro?

The best way to inject insulin lispro is with a pre-filled pen device. This allows for accurate dosing and ease of use. It is important to follow the instructions carefully while using the pen device to ensure that correct and safe dosage is administered.

What precautions should I take when using insulin lispro?

When using insulin lispro, it is important to avoid getting too much or too little insulin. Always follow the instructions given by your doctor or healthcare provider. Do not change the insulin dosage without consulting your doctor and never take extra shots of insulin.

Can I drive while taking insulin lispro?

Yes, you can drive while taking insulin lispro. However, it is important to check your blood sugar levels before driving and always be prepared in case of any hypoglycemia episodes.

Can insulin lispro be used with an insulin pump?

Yes, insulin lispro can be used with an insulin pump. However, always talk to your doctor or healthcare provider before using an insulin pump.

Should insulin lispro be taken at a specific time each day?

It is important to follow your doctor's instructions for taking insulin lispro. Generally, it is best to take insulin lispro shortly before a meal or immediately after a meal.

Can I exercise while taking insulin lispro?

Yes, you can exercise while taking insulin lispro. However, it is important to monitor your blood sugar levels before and after exercising to prevent hypoglycemia (low blood sugar).

What foods should I avoid if I'm taking insulin lispro?

Foods to avoid when taking insulin lispro include those high in fat, sugar, and refined carbohydrates. Eating a balanced diet is key for controlling blood sugar levels.

Does insulin lispro need to be injected at the same time each day?

It is important to follow the instructions given by your doctor or healthcare provider. Generally, it is recommended to take insulin lispro shortly before a meal or immediately after a meal.

What should I do if I forget to take my insulin lispro?

If you forget to take your insulin lispro, contact your doctor or healthcare provider to discuss the best plan for making up the missed dose.

What should I do if I accidentally take two doses of insulin lispro?

If you accidentally take two doses of insulin lispro, contact your doctor or healthcare provider right away. This could lead to low blood sugar (hypoglycemia) and should be monitored closely.

Can insulin lispro be used with mealtime insulin delivery systems?

Yes, insulin lispro can be used with mealtime insulin delivery systems such as insulin pens and insulin pumps.

How long does it take for insulin lispro to reach maximum effectiveness?

Insulin lispro typically reaches maximum effectiveness in 15 minutes to 1 hour after injection.

Are there any interactions between insulin lispro and other medications?

Yes, certain medications may interact with insulin lispro and can affect the way it works. Always talk to your doctor or healthcare provider about all the medications and supplements you are taking.

What should I do in case of an emergency while taking insulin lispro?

In case of an emergency while taking insulin lispro, contact your doctor or healthcare provider immediately. Severe low blood sugar (hypoglycemia) is a medical emergency and requires immediate medical attention.