Indomet SR
Indomet SR Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Indomet SR is a brand name. Its generic name is Indomethacin.
Indomet SR
Indomet SR is a non-steroidal anti-inflammatory drug (NSAID) belonging to the class of drugs called Indole Acetic Acid derivatives. It works by blocking the production of prostaglandins, the chemicals that cause inflammation, swelling, and pain which are responsible for symptoms caused by inflammatory diseases such as arthritis, tendinitis, bursitis, and gout. It is also used to alleviate migraine headaches and reduce fevers.
Uses for Indomet SR
Indomet SR is used to treat inflammatory diseases, reduce pain, swelling, and stiffness in joints and other structures. It is also used for pain relief in mild to moderate musculoskeletal and joint conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, tendinitis, and bursitis. It is also used for painful muscles and joints, such as caused by psoriatic arthritis, and to reduce fever caused by illnesses such as colds and flu.
Mechanism of Action
Indomet SR works by blocking the production of prostaglandins – the main chemical responsible for pain, swelling and inflammation. Blocking the production of prostaglandins can relieve inflammation, swelling and pain. By limiting the production of prostaglandins, indomethacin also reduces the inflammation and redness associated with certain conditions.
How Long Does It Take to Work?
The effects of indomethacin can be felt within 1-2 weeks, but it may take up to 6 weeks for the full effects to be seen. As with all medications, it's important to take indomethacin as directed and speak to a healthcare professional if any questions arise.
Absorption
Indomet SR is moderately absorbed from the gastrointestinal tract with peak concentrations reached 3 to 4 hours after oral administration.
Route of Elimination
Indomet SR is eliminated primarily by the kidneys via glomerular filtration and tubular secretion. Some is also metabolized in the liver by cytochrome P450 enzymes.
Dosage
The usual dose of indomethacin is 25-50 mg 3-4 times daily. The dose may be increased up to 100 mg 4 times daily, if necessary. It is important to take indomethacin exactly as prescribed by a doctor, and to not exceed the prescribed dose.
Administration
Indomet SR should be taken orally with food or a full glass of water to reduce side effects and to ensure that it is correctly absorbed. It should not be taken near meals or snacks as the food will reduce the absorption of the medication.
Side Effects
Common side effects include stomach upset, nausea, and vomiting, as well as headache, dizziness, and drowsiness. More serious side effects that require immediate medical attention include bloody stools or black, tarry stools, confusion, rapid heartbeat, or skin rash or itching.
Toxicity
Indomet SR is generally safe when taken at the recommended dosage. However, taking too much of this medication can cause serious side effects including kidney failure, abdominal pain, nausea, and vomiting. If any of these more serious side effects occur, contact a doctor immediately.
Precautions
Patients should inform their healthcare provider if they have any other medical conditions, are pregnant, breastfeeding, taking any medications or supplements, or have any allergies. Patients should also avoid activities that require alertness such as driving or operating machinery until the medication’s effects are known. Patients should not take indomethacin if bleeding or any other bleeding disorders are present.
Interactions
Indomet SR can interact with several other medications, including aspirin, NSAIDs, blood thinners, diuretics, lithium, and steroids. It is important to tell a healthcare provider about all medications being taken before starting indomethacin in order to avoid any drug interactions.
Disease Interactions
Patients with congestive heart failure or kidney or liver disease should not take indomethacin, as these conditions can increase the risk of certain side effects.
Drug Interactions
Indomet SR can interact negatively with certain drugs, including aspirin, NSAIDs, blood thinners, diuretics, lithium, and steroids. It is important to inform a healthcare provider about all medications being taken before starting indomethacin.
Food Interactions
Indomet SR should not be taken near meals or snacks as the food will reduce the absorption of the medication.
Pregnancy Use
Indomet SR should not be used by pregnant women, as it may cause harm to the unborn baby. Women who are breastfeeding should also not take indomethacin, as it can pass into breast milk.
Lactation Use
Indomet SR passes into breast milk and should not be taken by breastfeeding mothers.
Acute Overdose
Symptoms of acute indomethacin overdose may include nausea, vomiting, abdominal pain, dizziness, confusion, drowsiness, coma, and possibly seizures, coma, and death. If any of these side effects occur, seek medical attention immediately.
Contraindication
Indomet SR should not be taken by anyone with active gastrointestinal bleeding, history of bleeding disorders, or any other medical conditions that could be aggravated by taking indomethacin. It is also not recommended for use by people who are allergic to any of the ingredients in the medication.
Use Direction
It is important to take indomethacin exactly as prescribed. Do not use more or less than directed and never take it for a longer period of time than prescribed. The usual dose is 25-50 mg 3-4 times daily and may be increased up to 100 mg 4 times daily, if necessary.
Storage Condition
Store indomethacin at room temperature, away from direct sunlight, heat, and moisture. Do not store in the bathroom. Keep this medication away from children and pets.
Volume of Distribution
The volume of distribution of indomethacin is 0.17 L/kg.
Half-Life
The half-life of indomethacin is 2-4 hours.
Clearance
The clearance of indomethacin is 0.24 L/h/kg.
Here you find in details version of Indomet SR
Some Frequently Asked Questions About Indomet SR
What is Indomet SR?
Indomet SR is a nonsteroidal anti-inflammatory drug (NSAID) used to treat various forms of arthritis, as well as gout and pain caused by inflammation. It is a generic medication and is available over-the-counter as capsules or tablets.
What is Indomet SR used for?
Indomet SR is used to reduce pain, inflammation, and stiffness in people with gout, osteoarthritis, and pain caused by rheumatic conditions such as bursitis, tendinitis, and ankylosing spondylitis.
How does Indomet SR work?
Indomet SR blocks the production of prostaglandins, which are substances in the body that can contribute to inflammation in certain conditions. By blocking the production of prostaglandins, Indomet SR can reduce inflammation and pain.
How should I take Indomet SR?
Follow your doctor’s instructions for taking Indomet SR. It is usually taken every 8 hours, with or without food. Swallow the capsules or tablets whole with a glass of water. Do not split, chew, or crush the capsules or tablets.
What are the side effects of Indomet SR?
Common side effects of Indomet SR include nausea, stomach pain, diarrhea, heartburn, headache, dizziness, drowsiness, and rash. Some people may experience more serious side effects including low blood pressure, kidney or liver damage, and bleeding. Tell your doctor if you experience any side effects.
What should I avoid while taking Indomet SR?
Avoid drinking alcohol while taking Indomet SR as it may increase the risk of liver or kidney damage. Avoid taking aspirin or other NSAIDs while taking Indomet SR, as it may increase the risk of stomach ulcers or bleeding. Tell your doctor if you have any questions about what to avoid while taking Indomet SR.
Is Indomet SR safe to take while pregnant?
It is not known if Indomet SR is safe for use during pregnancy. Talk to your doctor if you are pregnant or planning to become pregnant before taking Indomet SR. It is not recommended for use during the last 3 months of pregnancy.
Can I take Indomet SR if I'm breastfeeding?
It is not known if Indomet SR passes into breast milk. Talk to your doctor before taking Indomet SR if you are breastfeeding. Alternative forms of relief should be considered if you are nursing.
When should I not take Indomet SR?
Do not take Indomet SR if you have a history of stomach ulcers or bleeding; have had an allergic reaction to Indomet SR or other NSAIDs; or have asthma, severe kidney or liver function impairment, or heart failure. Talk to your doctor before taking Indomet SR.
Should I tell my doctor about any medications I'm taking when prescribed Indomet SR?
Yes. Tell your doctor about all of the medications you are taking, including any over-the-counter medications, vitamins, or herbal supplements, as these could affect the way Indomet SR works. Your doctor may suggest alternative forms of relief for you or adjust your dosage to accommodate your other medications.
What should I do if I miss a dose of Indomet SR?
If you miss a dose of Indomet SR, take it as soon as you remember, unless it is almost time for your next dose. Do not take two doses of Indomet SR at the same time. If you take more than the prescribed dose, contact your doctor or poison control center for advice.
How long does it take for the effects of Indomet SR to start working?
The effects of Indomet SR usually start working within 1 to 2 days after starting treatment. However, it can take several days or longer before the full effects can be felt. Talk to your doctor if you have any questions about the effects of Indomet SR or how long before it will start working.
Can I take other medications while taking Indomet SR?
Some medications can interact with Indomet SR. Tell your doctor about all of the medications you are taking, including any over-the-counter medications, vitamins, or herbal supplements, as these can affect how Indomet SR works. Your doctor may suggest alternative forms of relief for you or adjust your dosage to accommodate your other medications.
What other drugs interact with Indomet SR?
Some medications can interact with Indomet SR. These medications include aspirin and other NSAIDs, diuretics, lithium, methotrexate, probenecid, and warfarin. Talk to your doctor about all of the medications you are taking before taking Indomet SR.
What would happen if I overdose on Indomet SR?
If you think you may have overdosed on Indomet SR, contact an emergency room or poison control center immediately. Symptoms of an Indomet SR overdose can include nausea, vomiting, stomach pain, drowsiness, and dizziness.
Is it safe to take Indomet SR for a long period of time?
Indomet SR is generally well-tolerated, but it can cause stomach ulcers and bleeding after long-term use. Talk to your doctor if you are considering taking Indomet SR for a long period of time or if you experience any side effects while taking it.
Will I experience withdrawal symptoms if I stop taking Indomet SR?
It is not common for people to experience withdrawal symptoms when stopping Indomet SR. However, if you have been taking it for a long period of time, you should talk to your doctor before stopping as they can advise you on how to safely stop taking it.
What are some possible alternatives to Indomet SR?
There are many alternative medications to Indomet SR for treating pain, inflammation, and stiffness in people with gout, osteoarthritis, and rheumatic conditions. Examples of alternative medications include ibuprofen, naproxen, and celecoxib. Talk to your doctor about alternatives to Indomet SR.
Can I take Indomet SR for migraines or headaches?
No, Indomet SR is not recommended for use in treating migraines or headaches. Talk to your doctor about other medications that can be taken for migraines or headaches.
What is the difference between Indomet SR and other NSAIDs?
Indomet SR is a nonsteroidal anti-inflammatory drug (NSAID) used to treat various forms of arthritis, as well as gout and pain caused by inflammation. Other NSAIDs work in a similar way but have different active ingredients. Talk to your doctor about which medication may be best for your symptoms.
Should I take Indomet SR on an empty stomach?
Indomet SR can be taken with or without food. It is important that you follow your doctor’s instructions for taking Indomet SR. Talk to your doctor if you have any questions about whether to take Indomet SR on an empty stomach.
What should I do if Indomet SR isn't working for my symptoms?
If Indomet SR isn't working for your symptoms, talk to your doctor. They may suggest alternative forms of relief for you or adjust your dosage. Do not increase your dosage of Indomet SR without talking to your doctor first.
Can I take Indomet SR if I'm allergic to aspirin or other NSAIDs?
No, Indomet SR should not be taken if you are allergic to aspirin or other NSAIDs. Talk to your doctor if you have any allergies that may affect your ability to take Indomet SR.
Does Indomet SR have any serious interactions with other medications or supplements?
Yes, some medications can interact with Indomet SR. These medications include aspirin and other NSAIDs, diuretics, lithium, methotrexate, probenecid, and warfarin. Talk to your doctor about all of the medications you are taking, including any supplements, before taking Indomet SR.
What should I do if I think I am experiencing side effects from Indomet SR?
If you are experiencing any side effects from Indomet SR, talk to your doctor right away. Do not stop taking the medication unless advised to do so by your doctor.
What is the maximum daily dose of Indomet SR I can take?
The maximum daily dose of Indomet SR depends on your individual medical history and the condition being treated. Talk to your doctor about the maximum daily dose of Indomet SR that is right for you.
Is Indomet SR available over-the-counter?
Indomet SR is available over-the-counter in the form of capsules or tablets. However, you should talk to your doctor before taking Indomet SR, as they can advise you on the correct dosage and any other medications or supplements you are taking.
How long does Indomet SR stay in my system?
Indomet SR has a half-life of approximately 4 to 7 hours, meaning that is the amount of time it takes for the drug to be reduced by half in the bloodstream. However, it can take several days or longer for the drug to be completely eliminated from your system.
Is Indomet SR safe for children to take?
No, Indomet SR is not recommended for use in children. Talk to your doctor about alternative forms of relief that may be safe for your child.
Should I take Indomet SR with food?
Indomet SR can be taken with or without food. It is important to follow your doctor's instructions for taking Indomet SR. Talk to your doctor about whether you should take Indomet SR with food.
Can I take Indomet SR if I have high blood pressure?
Yes, you can take Indomet SR if you have high blood pressure. However, it is important that you talk to your doctor about any conditions you have before taking it, as they can advise you on the correct dosage and any other medications or supplements you are taking.
Can I take Indomet SR if I have kidney or liver problems?
If you have kidney or liver problems, talk to your doctor before taking Indomet SR. Your doctor may suggest alternative forms of relief or adjust your dosage to accommodate your kidney or liver problems.
Does Indomet SR cause drowsiness?
Yes, drowsiness can be a side effect of taking Indomet SR. If you experience drowsiness while taking Indomet SR, do not drive or operate heavy machinery until these effects have worn off.
Could I become dependent on Indomet SR?
No, you cannot become physically dependent on Indomet SR. However, you should talk to your doctor before stopping use of Indomet SR, as they can advise you on how to safely stop taking it.
Is it safe to take Indomet SR with other pain relievers or anti-inflammatories?
No, it is not recommended to take Indomet SR with other pain relievers or anti-inflammatories. Talk to your doctor before taking any other medication or supplement while taking Indomet SR.
Can I drink alcohol while taking Indomet SR?
No, it is not recommended to drink alcohol while taking Indomet SR. Drinking alcohol while taking Indomet SR may increase the risk of kidney or liver damage.