Imuran

Imuran Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Imuran is a brand name. Its generic name is Azathioprine.

Introduction

Imuran (brand name Imuran) is an immunosuppressive drug used to treat autoimmune diseases and to prevent organ transplant rejection. It works by suppressing the body’s immune system, slowing down its ability to produce antibodies and other immune cells that attack and damage healthy cells, tissues, and organs.

Uses for

Imuran is mainly used to treat autoimmune diseases such as rheumatoid arthritis, Crohn’s disease, ulcerative colitis, and multiple sclerosis. It is also used to help prevent organ transplant rejection.

Mechanism of Action

Imuran works by inhibiting the growth of new immune system cells. It does this by blocking the production of certain amino acids necessary for cell growth and division. Imuran also inhibits the production of other immune system cells that can attack and damage healthy cells.

How Long Does it Take To Work?

It typically takes at least 2 to 3 weeks before the full therapeutic effects of azathioprine are seen. The time frame may vary depending on the individual and the disease being treated.

Absorption

Imuran is absorbed rapidly following oral administration. It is metabolized in the liver and is eliminated mainly through the kidneys.

Route of Elimination

Imuran is primarily eliminated from the body through the urine. Some of the metabolized drug is also excreted in the bile.

Dosage

The usual initial oral dose of Imuran is 2 to 3 mg per kg of body weight per day, divided into two equal doses and taken with food. The dose may be increased by 1 to 2 mg per kg of body weight per day at weekly intervals, up to a maximum dose of 5 to 6 mg per kg of body weight per day.

Administration

Imuran should be taken with meals, preferably at the same time each day. It is also available in tablets, capsules, and liquid forms.

Side Effects

Common side effects of azathioprine include nausea, vomiting, anorexia, hepatitis, jaundice, bone marrow suppression, anemia, and thrombocytopenia.

Toxicity

Imuran can be toxic if taken in high doses. Overdose can cause liver damage, nausea, vomiting, rash, and decreased immunity.

Precautions

Imuran should not be taken by people who are pregnant or nursing, or who have an impaired liver or kidney function. People taking Imuran should also avoid exposure to sunlight, since the drug can increase the risk of sunburn.

Interaction

Imuran may interact with other drugs, including antibiotics, antifungals, anti-parasitics, and some over the counter medications. People taking Imuran should speak with their doctor before taking any new prescription or nonprescription medications.

Disease Interaction

Imuran may worsen existing conditions such as leukemia, lupus, or an infection. It may also increase the risk of developing new conditions, such as cancers and other autoimmune diseases.

Drug Interaction

Imuran may interact with certain drugs, such as barbiturates, phenytoin, carbamazepine, and some antibiotics. People taking Imuran should speak with their doctor before taking any new prescription or non-prescription medications.

Food Interactions

Imuran may interact with certain foods, such as dairy products, citrus juices, and alcoholic beverages. People taking azathioprine should speak with their doctor about any foods that should be avoided.

Pregnancy Use

Imuran has not been studied in pregnant women and should not be used during pregnancy unless the potential benefits outweigh the potential risks. Women who are pregnant or planning to become pregnant should speak to their doctor before taking Imuran.

Lactation Use

Imuran has not been studied in nursing mothers and should not be used while breastfeeding. Women who are breastfeeding or planning to breastfeed should speak to their doctor before taking Imuran.

Acute Overdose

Symptoms of an acute overdose may include nausea, vomiting, rash, decreased immunity, and liver damage. If an overdose is suspected, the person should be taken to an emergency room for evaluation and treatment.

Contraindication

Imuran should not be taken by people who are pregnant or nursing, or who have an impaired liver or kidney function. People with a history of blood disorders, or with a weakened immune system, should speak with their doctor before taking azathioprine.

Use Direction

Imuran should be taken as directed by your doctor. It is typically taken once or twice daily with food. It is important to take Imuran at the same time every day to maintain an even level in your system.

Storage Conditions

Imuran should be stored at room temperature in an airtight container. Keep away from heat, moisture, and direct light.

Volume of Distribution

Imuran has a volume of distribution of 0.310 L/kg.

Half-Life

The elimination half-life of azathioprine is 2.3 hours.

Clearance

The clearance rate of azathioprine is 0.60 mL/min/kg.

Here you find in details version of Imuran

Some Frequently Asked Questions About Imuran

What is Imuran?

Imuran is a medication that is used to treat autoimmune conditions, such as rheumatoid arthritis and Crohn's disease. It is an immune-suppressing drug which works by decreasing the activity of the immune system, helping to slow down the progression of the disease.

What is the usual dosage of Imuran?

The usual dosage of Imuran is 50-250 mg per day, taken orally. The dose should be adjusted according to the response of your condition.

Is there any difference between Imuran and Imuran?

No, they are the same drug. The names are just different brand names for Imuran.

What are the side effects of taking Imuran?

The most common side effects when taking Imuran include nausea, vomiting, loss of appetite, stomach or abdominal pain, headache, dizziness, drowsiness, insomnia, weakness, constipation, and rash. Other less common side effects include hair loss, dry skin, and vision changes.

Is it safe to take Imuran during pregnancy?

It is not recommended to take Imuran during pregnancy due to the potential risks to the fetus. Discuss the risks and benefits of the drug with your doctor before taking it during pregnancy.

What interactions should be avoided when taking Imuran?

Imuran may interact with certain medications, such as blood thinners, steroids, cyclosporine, and tacrolimus, so it is important to discuss potential drug interactions with your doctor before taking Imuran.

Can I take Imuran with other medications?

Yes, you can take Imuran with other medications, but it is important to discuss potential drug interactions with your doctor before taking Imuran with any other medications.

What are the potential complications of taking Imuran?

The potential complications of taking Imuran include liver damage, increased risk of infection, bone marrow suppression, and an increased risk of developing certain types of cancer. Discuss the potential risks with your doctor before taking the medication.

What should I do if I miss a dose of my Imuran?

If you miss a dose of your Imuran, take it as soon as you remember, unless it is almost time for your next dose. If it is almost time for your next dose, skip the missed dose and take it at the usual time. Do not take a double dose to make up for a missed one.

Are there any alternatives to Imuran?

Yes, there are several alternative medications for treating autoimmune conditions, such as cyclosporine, methotrexate, and leflunomide. It is important to discuss the potential risks and benefits of these medications with your doctor before taking them.

What should I do if I experience a side effect while taking Imuran?

If you experience any side effects while taking Imuran, it is important to contact your doctor right away. Do not stop taking Imuran without consulting your doctor first.

How long does it take Imuran to work?

It typically takes several weeks for Imuran to start working and begin having an effect on your condition. The length of time may vary depending on the severity of your condition and the dosage of the drug.

Do I need to take Imuran for the rest of my life?

It is not always necessary to take Imuran for the rest of your life. It is important to discuss this with your doctor so that an individual treatment plan can be devised.

What should I avoid while taking Imuran?

It is important to avoid alcohol consumption while taking Imuran, as it can increase the risk of liver damage. It is also important to avoid exposure to sunlight and UV lights, as this can increase the risk of skin reactions and other side effects. Discuss any other potential risks and precautions with your doctor.

What should I do if I overdose on Imuran?

If you think you have overdosed on Imuran, seek medical help right away. Do not take any other medications without consulting your doctor first.

Can Imuran be used to treat other conditions besides autoimmune diseases?

Imuran may also be used to treat certain skin conditions and some types of cancer, such as lymphoma and dermatomyositis. It is important to discuss any potential risks and benefits of the drug with your doctor before taking it.

How is Imuran supplied?

Imuran is a tablet that is supplied in 25 mg and 50 mg doses. The tablets can be taken orally, or they can be administered as an injection.

What is the recommended storage temperature for Imuran?

Imuran should be stored at room temperature between 15-25°C (59-77°F). It is important to keep this medication away from light, heat, and moisture.

What makes Imuran different from other immunosuppressants?

Imuran is an immunosuppressant drug that works by targeting the immune system and decreasing its activity. This makes it different from other immunosuppressants, which may also target other body systems. It is important to discuss any potential risks and benefits of the drug with your doctor before taking it.

Can I take Imuran if I have certain allergies?

If you have any known allergies, you should discuss them with your doctor before taking Imuran. This is to ensure that the drug will be safe for you to take and that you are not at an increased risk of any allergic reactions.

Does Imuran increase the risk of infection?

Yes, Imuran suppresses the activity of the immune system, which increases the risk of infection. It is important to take any preventative measures you can to avoid getting sick while taking this medication.

Is there a generic version of Imuran available?

Yes, there is a generic version of Imuran available. The name of the generic version is Imuran.

Can I still take Imuran if I have kidney problems?

If you have kidney problems, it is important to discuss them with your doctor before taking Imuran. Your doctor may lower the dosage or adjust the frequency of the medication to ensure that it is safe for you to take.

Can I donate blood while taking Imuran?

No, it is not recommended to donate blood while taking Imuran, as the drug can be passed into the blood supply. Talk to your doctor if you have any questions.

Can I take electrolyte supplements while on Imuran?

Yes, you can take electrolyte supplements while taking Imuran. However, it is important to check with your doctor before taking any supplements, as they could interact with the medication.

What is the recommended time to take Imuran?

It is recommended to take Imuran once per day, in the morning. You can take it with or without food. It is important to take the medication at the same time each day to maintain an even level in your system.

Can I take Imuran if I am pregnant or breastfeeding?

It is not recommended to take Imuran if you are pregnant or breastfeeding. This is because it can be passed from the mother to the baby and can cause harm. Discuss the potential risks and benefits of the drug with your doctor before taking it.

Can Imuran cause liver damage?

Yes, taking Imuran can increase the risk of liver damage. It is important to discuss any potential risks with your doctor before taking this medication.

Can I take a multivitamin while taking Imuran?

Yes, you can take a multivitamin while taking Imuran. However, it is important to check with your doctor before taking any additional supplements, as they could interact with the medication.

What are the long-term effects of taking Imuran?

The long-term effects of taking Imuran can vary, but they can include an increased risk of bone marrow suppression, increased risk of liver damage, and an increased risk of developing certain types of cancers. Discuss any potential long-term effects with your doctor before taking the medication.

Can I take Imuran if I have an infection?

No, it is not recommended to take Imuran if you have an infection, as it can increase the risk of the infection spreading. It is important to discuss any potential infection with your doctor before taking the medication.

Can I take herbal supplements while taking Imuran?

Yes, you can take herbal supplements while taking Imuran. However, it is important to check with your doctor before taking any supplements, as they could interact with the medication.

What happens if I accidentally take too much Imuran?

If you accidentally take too much Imuran, it is important to seek medical help right away. Do not take any other medications without consulting your doctor first.

What should I do if I experience a serious side effect while taking Imuran?

If you experience any serious side effects while taking Imuran, it is important to get medical help right away. Do not stop taking the medication without consulting your doctor first.

What should I do if I experience a rash or other skin reactions while taking Imuran?

If you experience any rash or other skin reactions while taking Imuran, it is important to seek medical help right away. Do not stop taking the medication without consulting your doctor first.

Can Imuran cause weight gain?

Yes, taking Imuran can increase the risk of weight gain. It is important to discuss any potential risks with your doctor before taking the medication.

Is Imuran safe for children?

Imuran is not recommended for children under the age of 6. It is important to discuss the potential risks and benefits of the drug with your doctor before giving it to a child.

Can I take Imuran if I have high blood pressure?

Yes, you can take Imuran if you have high blood pressure. However, it is important to discuss any potential risks with your doctor before taking the medication.

Does Imuran cause dizziness?

Yes, taking Imuran can increase the risk of dizziness. It is important to discuss any potential risks with your doctor before taking the medication.

Does Imuran raise blood sugar levels?

Yes, taking Imuran can increase the risk of high blood sugar levels. It is important to discuss any potential risks with your doctor before taking the medication.

Is it safe to take Imuran if I have heart disease?

It is not recommended to take Imuran if you have heart disease, as the drug can increase the risk of complications. Discuss the potential risks and benefits of the drug with your doctor before taking it.

Can I take Imuran if I have an allergy to other medications?

If you have any known allergies, it is important to discuss them with your doctor before taking Imuran. This is to ensure that the drug will be safe for you to take and that you are not at an increased risk of any allergic reactions.