Imipramine BP

Imipramine BP, a brand name for a formulation containing essential Imipramine, is widely used for various health benefits. This guide provides comprehensive information on the uses, dosage, side effects, and mechanism of action of Imipramine BP, as well as insights into how long it takes to work. Understanding these aspects can help you make informed decisions about its use and effectiveness.

Introduction

Imipramine BP is a tricyclic antidepressant (TCA). It is classified as a tricyclic dibenzazepine-derivative. Imipramine BP was developed in the 1950s as a treatment for depression and anxiety. Imipramine BP is approved by the U.S. Food and Drug Administration (FDA) for the treatment of depression and panic disorder. Imipramine BP is also used off-label to treat certain neurologic conditions, pain, and other mental health disorders.

Uses

Imipramine BP is used to treat depression, pain, panic disorder, agoraphobia (fear of places where escape might be difficult), and nightime bedwetting (nocturnal enuresis). It can also be used off-label to treat obsessive-compulsive disorder (OCD), post traumatic stress disorder (PTSD), and attention deficit hyperactivity disorder (ADHD).

Mechanism Of Action

Imipramine BP works by inhibiting the reuptake of serotonin and noradrenaline, which increases levels in the synaptic junction. This in turn helps to improve mood and symptoms associated with depression. Imipramine BP also works on the smooth muscle cells to reduce anxiety.

How Long Does It Take To Work?

It generally takes 2-4 weeks for Imipramine BP to work. However, symptom improvement may occur as early as one week after the start of treatment.

Absorption

Imipramine BP is readily absorbed from the gastrointestinal tract. It reaches peak serum concentrations 12-24 hours after administration.

Route Of Elimination

Imipramine BP is metabolized and excreted in the urine. Approximately 75-85% of a dose of Imipramine BP is eliminated within 72 hours.

Dosage

The recommended starting dose of Imipramine BP is 75-150mg taken orally once daily. The dose may be increased by 25-50mg every 3-4 days, up to a maximum of 300mg/day. The dose should be divided into two or three doses per day. It is important to consult your doctor for the most appropriate dosing regimen for you.

Administration

Imipramine BP should be taken with food or milk. It is important to take the medication at the same time each day to maintain an even level in the blood. It should be taken as prescribed and not stopped abruptly without the consultation of a doctor.

Side Effect

Common side effects include dry mouth, drowsiness, nausea, vomiting, constipation, blurred vision, and lightheadedness. Less common side effects include confusion, feeling agitated or restless, increased heart rate, decreased appetite, sexual problems, difficulty urinating, and increased sweating.

Toxicity

Overdose with Imipramine BP can be fatal. Symptoms of overdose may include confusion, seizures, and an irregular heart rhythm. Treatment for overdose may include activated charcoal, gastric lavage, IV fluids, and IV medications.

Precautions

Before taking Imipramine BP, tell your doctor if you have any of the following: liver or kidney disease, heart disease, glaucoma, seizures or epilepsy, a history of drug abuse, and bipolar disorder. Imipramine BP may cause drowsiness or impair your ability to react and think quickly. Do not drive or operate heavy machinery until you know how Imipramine BP will affect you.

Interactions

Imipramine BP may interact with other medications. Tell your doctor all medications and supplements you are taking. It is important to avoid taking Imipramine BP with MAO inhibitors, such as isocarboxazid, phenelzine, tranylcypromine, and selegiline.

Disease Interaction

Imipramine BP may interact with certain diseases. Tell your doctor if you have a history of heart disease, kidney disease, liver disease, seizure disorder, or bipolar disorder. Imipramine BP may worsen the symptoms of these conditions.

Drug Interaction

Imipramine BP may interact with other medications. Tell your doctor all medications and supplements you are taking. Avoid taking Imipramine BP with MAO inhibitors, such as isocarboxazid, phenelzine, tranylcypromine, and selegiline. Other medications that may interact with Imipramine BP include Cimetidine, Propafenone, Quinidine, Phenobarbital, Phenytoin, Amiodarone, and Thioridazine.

Food Interactions

Imipramine BP may interact with certain foods. Avoid drinking alcohol while taking Imipramine BP, as this may increase the risk of certain side effects. Avoid taking Imipramine BP with grapefruit juice as this may increase the risk of unusual side effects.

Pregnancy Use

Imipramine BP should not be used during pregnancy. It can cause serious harm to a developing fetus. If you become pregnant while taking Imipramine BP, notify your doctor immediately. Imipramine BP use during the third trimester of pregnancy may cause withdrawal symptoms in the newborn such as seizures or irritability.

Lactation Use

Imipramine BP is excreted in breast milk and should be used with caution in nursing mothers. Talk to your doctor before breastfeeding while taking Imipramine BP.

Acute Overdose

An acute overdose with Imipramine BP can be fatal. Symptoms of an overdose may include confusion, seizures, and an irregular heart rhythm. Treatment for overdose may include activated charcoal, gastric lavage, IV fluids, and IV medications.

Contraindication

Imipramine BP should not be used in individuals with a known hypersensitivity to the medication. It should also be avoided in patients who are taking MAO inhibitors. It is also contraindicated in patients with cardiovascular disorders, glaucoma, and thyroid disorders.

Use Direction

Imipramine BP should be taken exactly as prescribed. Do not skip doses or stop taking the medication abruptly without consulting your doctor. Take Imipramine BP with food or milk. It is important to take the medication at the same time each day to maintain an even level in the blood.

Storage Condition

Store Imipramine BP in a sealed container in a dry, cool place away from direct sunlight.

Volume Of Distribution

The volume of distribution of Imipramine BP is approximately 20L/kg.

Half Life

The half life of Imipramine BP is 10-23 hours.

Clearance

The total body clearance of Imipramine BP is approximately 40 mL/min/kg.

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