Hepa-B
Hepa-B Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Hepa-B is a brand name. Its generic name is Hepatitis B Vaccine (rDNA).
Introduction
Hepatitis B vaccine (rDNA) is a recombinant vaccine manufactured using modern techniques of molecular biology. It contains the antigenic material prepared from plasmids carrying a gene which encodes a specific type of hepatitis B surface antigen (HBsAg).Uses
Hepatitis B vaccine (rDNA) is used for the prevention of hepatitis B infection and subsequent development of chronic hepatitis B. It is typically administered to infants, adolescents, and adults at risk for hepatitis B, such as those with multiple sexual partners, personnel of medical institutions, and drug users.Mechanism of Action
When a person is immunized with the vaccine, the antigen within the vaccine is recognized by the immune system and generates antibodies. These antibodies bind to the surface antigen on the hepatitis B virus, thus neutralizing it and preventing it from entering the cells.How Long Does It Take To Work?
It typically takes 10 to 14 days after immunization for the body to develop the optimal levels of protective antibodies against the virus. However, it may take up to six months for the protective antibodies to reach their maximum levels.Absorption
Hepatitis B vaccine (rDNA) is rapidly absorbed after intramuscular injection or administration via injection.Route of Elimination
The primary route of elimination of the vaccine is through the kidneys, where it is eliminated as metabolites in the urine.Dosage
The typical dose of hepatitis B vaccine (rDNA) is 20mcg in 0.5mL of reconstituted vaccine, given intramuscularly. In infants below the age of 12 months, the dose is 0.5mL without reconstitution, and should be given intramuscularly. In adults, the dose is 0.5mL of reconstituted vaccine intramuscularly.Administration
The vaccine is usually administered intramuscularly, either in the shoulder or thigh. It should not be administered intravenously, orally, or intranasally, as this will reduce its efficacy.Side Effects
The most common side effects associated with hepatitis B vaccine (rDNA) include mild fever, headache, nausea, injection site pain/swelling/redness, muscle pain, and joint pain. Severe allergic reactions to the vaccine are rare.Toxicity
No evidence of significant toxicity has been observed with hepatitis B vaccine (rDNA). However, if the vaccine is administered to immunodeficient patients, it may lead to increased risk of serious side effects and even death.Precautions
Individuals with pre-existing immune system disorders, active infection from hepatitis B, or hypersensitivity/allergy to the vaccine, its components, or other yeast-derived products should not receive the vaccine.Interaction
Hepatitis B vaccine (rDNA) may interact with other drugs or vaccines in immunodeficient individuals, causing a possible increase in adverse reactions or reduced efficacy.Disease Interaction
Hepatitis B vaccine (rDNA) should not be administered to individuals who have an active infection from hepatitis B or are immunodeficient.Drug Interaction
Concurrent administration of hepatitis B vaccine (rDNA) with other drugs or vaccines may increase the risk of adverse reactions or reduced efficacy.Food Interaction
No food/drug interactions have been observed with hepatitis B vaccine (rDNA).Pregnancy Use
Hepatitis B vaccine (rDNA) should not be administered to pregnant women, as its safety in this population has not been established.Lactation Use
Hepatitis B vaccine (rDNA) should not be administered to lactating women, as its safety in this population has not been established.Acute Overdose
No evidence of acute overdose with hepatitis B vaccine (rDNA) has been observed.Contraindication
Individuals with pre-existing immune system disorders, active infection from hepatitis B, or hypersensitivity/allergy to the vaccine, its components, or other yeast-derived products should not receive the vaccine.Use Direction
Hepatitis B vaccine (rDNA) is usually administered as a single intramuscular injection followed by two additional doses, spaced one month and six months apart.Storage Condition
Hepatitis B vaccine (rDNA) should be stored at temperatures between 2°C to 8°C (36°F to 46°F).Volume of Distribution
No specific information is available regarding the volume of distribution of hepatitis B vaccine (rDNA).Half Life
No specific information is available regarding the half-life of hepatitis B vaccine (rDNA).Clearance
No specific information is available regarding the clearance of hepatitis B vaccine (rDNA).Here you find in details version of Hepa-B
Some Frequently Asked Questions About Hepa-B
.What is rDNA Hepatitis B Vaccine?
Recombinant DNA (rDNA) Hepatitis B Vaccine is a vaccine designed to protect against hepatitis B virus (HBV) infection. It is manufactured using a recombinant HBV surface antigen (HBsAg) gene, and is approved by the U.S. Food and Drug Administration (FDA) for use in adults, adolescents, and children over six months of age. It is given as a series of three intramuscular injections.
What is the purpose of rDNA Hepatitis B Vaccine?
The purpose of the rDNA Hepatitis B Vaccine is to prevent individuals from becoming infected with the hepatitis B virus. It is most effective when given in the first year of life, but may be given at any age. Studies have shown that the vaccine is effective in preventing HBV infection in 95-100% of individuals who receive the three doses.
What are the components of the rDNA vaccine?
The rDNA vaccine contains a recombinant hepatitis B surface antigen, which stimulates immunity to the virus. Adjuvants and preservatives may be included in the vaccine, such as aluminum hydroxide, sodium chloride, and phosphate. The vaccine does not contain any live virus.
How is the rDNA Hepatitis B Vaccine administered?
The rDNA Hepatitis B Vaccine is administered as a series of three intramuscular injections. The first dose is given at birth, the second dose at one month of age, and the third dose at six months of age. The vaccine is available in both liquid and unit-dose vials.
How effective is the rDNA Hepatitis B Vaccine?
Studies have shown that the rDNA Hepatitis B Vaccine is effective in 95-100% of individuals who receive all three doses. The vaccine is most effective when all three doses are given in the first year of life.
Who should receive the rDNA Hepatitis B Vaccine?
The rDNA Hepatitis B Vaccine is recommended for all infants and children, adolescents, and adults who are either at increased risk of HBV infection or who have existing risk factors for infection. It is also recommended for individuals with certain medical conditions, such as chronic liver disease, and for healthcare workers.
Can the rDNA Hepatitis B Vaccine be given to pregnant women?
Yes, the rDNA Hepatitis B Vaccine can be given to pregnant women if they are at increased risk of HBV infection or have other risk factors for infection. It is not recommended for pregnant women who do not have risk factors for infection.
Are there any side effects associated with the rDNA Hepatitis B Vaccine?
Some people may experience side effects after receiving the rDNA Hepatitis B Vaccine, such as soreness, redness, and swelling at the site of injection. Other potential side effects may include headache, fatigue, muscle aches, and fever. However, these side effects are generally mild and most resolve within a few days.
What should I do if the person experiencing the side effects after receiving the rDNA Hepatitis B Vaccine?
If the person experiencing side effects after receiving the rDNA Hepatitis B Vaccine, it is recommended to contact their doctor or healthcare provider. They may recommend over-the-counter medicines such as ibuprofen or acetaminophen to relieve the discomfort.
Is the rDNA Hepatitis B Vaccine safe?
Yes, the rDNA Hepatitis B Vaccine is safe and effective. It has been studied extensively and has been found to be well-tolerated with no serious side effects. It has been approved by the FDA for use in adults, adolescents, and children over six months of age.
Is the rDNA Hepatitis B Vaccine effective for those who are already infected with the virus?
No. The rDNA Hepatitis B Vaccine is only effective for those who are not infected with the virus. Those who have already had HBV infection cannot be vaccinated and must be treated differently.
Are there any alternatives to the rDNA Hepatitis B Vaccine?
Yes, there are alternative hepatitis B vaccines available, such as an inactivated hepatitis B vaccine (Engerix-B) and a recombinant subunit hepatitis B vaccine (Heplisav-B), both of which are approved by the FDA for use in adults, adolescents, and children over six months of age.
What is the schedule for the rDNA Hepatitis B Vaccine?
The rDNA Hepatitis B Vaccine is typically given as a series of three intramuscular injections. The first dose is given at birth, the second dose at one month of age, and the third dose at six months of age. It is most effective when all three doses are given in the first year of life.
Does the rDNA Hepatitis B Vaccine protect against all forms of hepatitis B?
No, the rDNA Hepatitis B Vaccine provides protection against acute and chronic HBV infection, but does not provide protection against other forms of hepatitis B such as delta hepatitis, which is caused by a different virus.
How long does the rDNA Hepatitis B Vaccine protect against HBV?
The rDNA Hepatitis B Vaccine provides protection against HBV for an extended period of time. Studies have shown that vaccination is effective in 95-100% of individuals for at least 10 years after vaccination.
How much does the rDNA Hepatitis B Vaccine cost?
The cost of the rDNA Hepatitis B Vaccine varies depending on the brand and dosage. A 3-dose vial may cost anywhere from $20 to $200 per dose, while a 5-dose vial may cost up to $1000.
Is there a risk of allergic reaction to the rDNA Hepatitis B vaccine?
Yes, as with any vaccine, there is a small risk of allergic reaction to the rDNA Hepatitis B vaccine. If you experience any symptoms such as rash, hives, difficulty breathing, or swelling after receiving the vaccine, you should seek medical attention immediately.
Is it safe to receive the rDNA hepatitis B vaccine if I have other medical conditions?
Yes, it is generally safe to receive the rDNA hepatitis B vaccine if you have other medical conditions. However, you should consult your doctor or healthcare provider to determine if the vaccine is appropriate for you. They will be able to provide you with more information.
Can I get a booster dose of the rDNA hepatitis B vaccine?
No, there is no need to get a booster dose of the rDNA hepatitis B vaccine. Studies have shown that vaccination is effective in 95-100% of individuals for at least 10 years after vaccination.
Can I receive the rDNA hepatitis B vaccine if I am immunocompromised?
Yes, it is safe to receive the rDNA hepatitis B vaccine if you are immunocompromised. However, your doctor or healthcare provider may need to adjust the schedule, as some immunocompromised individuals may need to receive the vaccine more frequently.
Can I get the rDNA hepatitis B vaccine if I am breastfeeding?
Yes, it is safe to get the rDNA hepatitis B vaccine if you are breastfeeding. However, you should consult your doctor or healthcare provider to determine if the vaccine is appropriate for you.
Can I give my child the rDNA hepatitis B vaccine if I am pregnant?
No, it is not recommended to give a child the rDNA hepatitis B vaccine if you are pregnant due to the risk of passing the virus to the baby. If you are already pregnant, you should consult your doctor or healthcare provider to determine if the vaccine is appropriate for you.
Can individuals with HIV receive the rDNA hepatitis B vaccine?
Yes, it is safe for individuals with HIV to receive the rDNA hepatitis B vaccine. However, your doctor or healthcare provider may need to adjust the schedule, as some individuals with HIV may need to receive the vaccine more frequently.
Can the rDNA hepatitis B vaccine protect against liver cancer?
No, the rDNA hepatitis B vaccine does not protect against liver cancer. The vaccine provides protection against acute and chronic HBV infection, but does not provide protection against other forms of hepatitis B or liver cancer.
Do I still need to get a test for hepatitis B after receiving the rDNA hepatitis B vaccine?
Yes, it is recommended to get a test for hepatitis B after receiving the rDNA hepatitis B vaccine. It is important to check that your body is responding to the vaccine and that you are still protected against HBV infection.
Can the rDNA hepatitis B vaccine be used to treat existing HBV infections?
No, the rDNA hepatitis B vaccine is designed to prevent HBV infection and cannot be used to treat an existing infection. Those who have already had HBV infection must be treated differently.
Are there any potential interactions between the rDNA hepatitis B vaccine and other medications?
Yes, there may be potential interactions between the rDNA hepatitis B vaccine and other medications. It is important to consult your doctor or healthcare provider before receiving the vaccine if you are taking any other medications.
How long does it take for the rDNA hepatitis B vaccine to take effect?
The rDNA hepatitis B vaccine takes approximately four weeks to take effect. It is most effective when all three doses are given in the first year of life.
Can the rDNA hepatitis B vaccine cause HBV infection?
No, the rDNA hepatitis B vaccine does not contain live virus and therefore cannot cause HBV infection. It stimulates the body’s immune system to produce antibodies against the virus, thus preventing infection.
Can I get the rDNA hepatitis B vaccine if I have previously been exposed to HBV?
Yes, it is safe to get the rDNA hepatitis B vaccine if you have previously been exposed to HBV. However, it is important to consult your doctor or healthcare provider to determine if vaccination is indicated in your particular situation.
Do I need to get a booster dose of the rDNA hepatitis B vaccine if I receive it after the age of six months?
No, there is no need to get a booster dose of the rDNA hepatitis B vaccine if it is received after the age of six months. The vaccine provides protection against HBV for at least 10 years after vaccination, regardless of age at which it is received.
Can certain other vaccines interfere with the rDNA hepatitis B vaccine?
Yes, certain vaccines may interfere with the rDNA hepatitis B vaccine. It is important to consult your doctor or healthcare provider before receiving any other vaccines or medications to determine if they may interfere with the hepatitis B vaccine.
What should I do if I miss a dose of the rDNA hepatitis B vaccine?
If you miss a dose of the rDNA hepatitis B vaccine, it is important to contact your doctor or healthcare provider to reschedule the missed dose. The schedule for the vaccine may need to be adjusted for delayed or missed doses.