Glucophage SR

Glucophage SR, a brand name for a formulation containing essential Metformin, is widely used for various health benefits. This guide provides comprehensive information on the uses, dosage, side effects, and mechanism of action of Glucophage SR, as well as insights into how long it takes to work. Understanding these aspects can help you make informed decisions about its use and effectiveness.

Glucophage SR

Glucophage SR is a medication used to treat type 2 diabetes mellitus (T2DM). It works by lowering the amount of sugar produced by the liver and preventing cells from absorbing sugar in the bloodstream. Glucophage SR also increases insulin sensitivity in the body.

Uses For Glucophage SR

Glucophage SR is used to treat type 2 diabetes mellitus by helping the body to regulate blood sugar levels and reduce the amount of glucose produced by the liver. It can also help prevent the risk of developing complications from diabetes, such as stroke, heart attack, and kidney failure.

Mechanism of Action

Glucophage SR works mainly by inhibiting the production of glucose in the liver and increasing the sensitivity of peripheral tissues to the action of insulin. The drug also reduces the absorption of glucose in the small intestine, leading to an overall decrease in circulating glucose levels.

How Long Does It Take to Work?

The effects of metformin can be felt within one week of starting the drug. After four weeks, the desired benefits should start to be noticed. However, it may take up to three months to reach the full effect of the drug.


Glucophage SR is absorbed quickly from the gastrointestinal tract. Peak plasma levels are usually seen within 2-4 hours after oral administration.

Route of Elimination

Glucophage SR is primarily excreted via the urinary system, with approximately 50% to 75% of the drug being eliminated in the urine as unchanged metformin.


Glucophage SR is available as an oral tablet or liquid solution in dosages ranging from 500mg to 2000mg. The typical starting dose is 500mg twice a day orally with meals. The maximum daily dose is usually 2000mg per day.


Glucophage SR is typically taken by mouth with food twice a day. The tablets should be swallowed whole and not crushed or chewed. The liquid form of the drug should be taken with meals as well, preferably in divided doses.

Side Effects

Common side effects of metformin include abdominal pain, diarrhoea, nausea, vomiting, and metallic taste. Rare but serious side effects include lactic acidosis and hypoglycemia.


Glucophage SR is well tolerated and has a low rate of toxicity. If taken at prescribed doses, it can be safely used for a long period of time.


Patients with renal, hepatic, or heart disease should consult their doctor before taking metformin. Patients should also inform their doctor if they have any history of alcohol abuse or liver disease.


Patients should inform their doctor of all medications and supplements they are taking before taking metformin. This is to ensure that there are no drug interactions or adverse reactions.

Disease Interactions

Glucophage SR can alter the effects of certain medications and can increase the risk of adverse reactions in patients with liver, kidney, or heart disease.

Drug Interactions

Glucophage SR interacts with many medications, including some common and over the counter products. Patients should always inform their doctor of any other medications they are taking before taking metformin.

Food Interactions

Certain foods may interact with metformin, such as certain antacids, mineral or calcium supplements, alcohol, or grapefruit juice. Patients should always consult their doctor or pharmacist before adding any dietary supplements to their regimen.

Pregnancy Use

Glucophage SR is not recommended for pregnant women. If a woman becomes pregnant while taking metformin, she should stop taking the medication and talk to her doctor about alternative options.

Lactation Use

Glucophage SR is not recommended for use in lactating mothers due to the potential for adverse effects to the baby.

Acute Overdose

An acute overdose of metformin can be dangerous and life-threatening. Symptoms of an overdose include vomiting, confusion, and lactic acidosis. Treatment includes supportive care and administration of folic acid or insulin.


Glucophage SR is contraindicated in patients with hypoglycemia, kidney disease, and heart failure. It should also be avoided in patients with a history of alcoholic liver disease.

Use Direction

Glucophage SR should be taken with food twice a day at evenly spaced intervals. Patients should take the dose that is prescribed by their doctor and should only take the prescribed amount. They should also avoid taking higher doses than prescribed.

Storage Condition

Glucophage SR should be stored at room temperature away from heat, moisture, and direct sunlight. It should also be stored away from children and pets.

Volume of Distribution

The volume of distribution of Glucophage SR is approximately 17–22 L/kg.

Half Life

The half-life of Glucophage SR is approximately 4–6 hours.


Glucophage SR is cleared from the body primarily by the kidneys. The clearance of Glucophage SR is approximately 5–10 L/h/kg.

Here you find in details version of Glucophage SR,,,,,,,,,,,,,,,,,,,,,,,,,,,,,