Glucium-D
Glucium-D Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Glucium-D is a brand name. Its generic name is Diacerein + Glucosamine Sulphate.
Introduction
Diacerein is an anti-inflammatory analgesic agent of the phenylacetonitrile group, and it is available in combination with glucosamine sulfate to manage osteoarthritis and joint pain. Glucosamine sulfate is an amino sugar and a popular dietary supplement used in treating joint diseases such as osteoarthritis, rheumatoid arthritis and joint pains. The combination of Diacerein and Glucosamine Sulphate helps to relieve the symptoms for Osteoarthritis.
Uses
This combination of Diacerein and Glucosamine Sulphate is used to reduce pain and improve the functional condition in patients with mild to moderate Osteoarthritis. This treatment has shown to reduce the symptoms of joint pain and reduce the overall damage to the joint.
Mechanism of Action
Both Diacerein and Glucosamine Sulphate joint together to treat the Osteoarthritis symptoms. Diacerein works by inhibiting the production of pro-inflammatory substances like IL-1 and TNF-alpha in the body which helps to reduce the pain. Glucosamine Sulphate helps to increase the production of Hyaluonan which helps to reduce inflammation and assist in repairing the joint tissue.
How Long Does It Take to Work?
The response of Diacerein and Glucosamine Sulphate combination treatment may vary from person to person but it usually takes about 3-4 weeks to experience the full benefits of this therapy. The duration of this therapy depends on the severity of Osteoarthritis and individual health condition.
Absorption
Diacerein is highly bioavailable and it is rapidly absorbed after oral administration with peak plasma concentrations of approximately 2 µg/ml achieved in 2-3 hours. Glucosamine Sulphate, on the other hand, has low bioavailability with a peak concentration of about 0.08 µg/ml achieved in 4-5 hours after oral administration.
Route of Elimination
The elimination of Diacerein is mainly through renal mechanisms. About 65% to 80% of a single dose is excreted in the urine and elimination half-life is 3 to 5 hours. Glucosamine Sulphate is mainly eliminated through biliary secretion with an elimination half-life of 4-7 hours.
Dosage
The dosage of Diacerein and Glucosamine Sulphate combination depends on the age, weight and severity of Osteoarthritis in a patient. Generally, it is prescribed in the form of a capsule of 50 mg Diacerein and 500 mg Glucosamine Sulphate. Two capsules per day should be taken orally with meals or as prescribed by the doctor.
Administration
Diacerein and Glucosamine Sulphate combination should be taken orally with food or as prescribed by the doctor. The capsules should be swallowed with a full glass of liquid and it should not be broken, chewed or destroyed. If a dose is missed, it should be taken as soon as possible but not if it is almost time for the next dose. The dose should not be doubled.
Side Effects
The common side effects of Diacerein and Glucosamine Sulphate combination include nausea, vomiting, abdominal discomfort, constipation, diarrhea, itching, skin rash and headache. If these side effects persist or worsen, one should seek medical advice immediately.
Toxicity
There is no known toxicity associated with long-term usage of Diacerein and Glucosamine Sulphate combination. However, if ongoing symptoms persist or worsen, seek medical help immediately.
Precautions
- Patients with liver or kidney problems should use this medication with caution.
- Patients with hypersensitivity to Diacerein or Glucosamine Sulphate should not use this medicine.
- People taking other medications should consult their doctor before starting this therapy.
- Pregnant or breastfeeding women should consult their doctor before using this therapy.
- This medicine should not be used in the treatment of children under the age of 18.
Interaction
Diacerein and Glucosamine Sulphate combination can interact with certain drugs, such as antibiotics, warfarin, aspirin, diuretics, etc. It is important to inform the doctor about other medications being taken while initiating the therapy with this combination.
Disease Interaction
Diacerein and Glucosamine Sulphate combination can interact with certain medical conditions such as asthma, liver disease, kidney disease, diabetes, hypertension, etc. It is important to inform the doctor about any medical condition before initiating the therapy with this combination.
Drug Interaction
Diacerein and Glucosamine Sulphate combination can interact with certain medications such as antibiotics, warfarin, aspirin, diuretics, etc. It is important to inform the doctor about other medications being taken while initiating the therapy with this combination.
Food Interactions
Diacerein and Glucosamine Sulphate combination may interact with certain foods and beverages like tea, coffee, alcohol, etc. It is important to inform the doctor about any food or beverage being taken while initiating the therapy with this combination.
Pregnancy Use
Diacerein and Glucosamine Sulphate combination should be used with caution in pregnant women. It is not recommended to use this medication in the first trimester of pregnancy or in women who are planning for pregnancy. It is recommended to consult the doctor before taking this medication during pregnancy.
Lactation Use
Diacerein and Glucosamine Sulphate combination should be used with caution in lactating women. It is advised to consult the doctor before taking this medication while breastfeeding.
Acute Overdose
The symptoms of acute overdose depend on the amount taken and it may include abdominal pain, nausea and vomiting. It is advised to seek medical help immediately in case of an overdose.
Contraindication
Diacerein and Glucosamine Sulphate combination is contraindicated in patients with known hypersensitivity to Diacerein or Glucosamine Sulphate or any other ingredients in the combination.
Use Direction
Diacerein and Glucosamine Sulphate combination should be taken as prescribed by the doctor. The capsules should be swallowed with a full glass of liquid and should not be chewed, broken or destroyed. It should not be taken in larger or smaller amounts than prescribed by the doctor.
Storage Condition
Diacerein and Glucosamine Sulphate combination should be stored at room temperature, away from heat and direct light. It should be stored in a place which is not accessible to children and pets.
Volume of Distribution
The volume of distribution of Diacerein and Glucosamine Sulphate combination is not known.
Half Life
The half-life of Diacerein is 3-5 hours, and the half-life of Glucosamine Sulphate is 4-7 hours.
Clearance
The clearance of Diacerein and Glucosamine Sulphate combination is not known.
Here you find in details version of Glucium-D
Some Frequently Asked Questions About Glucium-D
What is Glucium-D?
Glucium-D is a combination of two active ingredients, Diacerein and Glucosamine Sulphate, which are both used to treat osteoarthritis. The combination of Diacerein and Glucosamine Sulphate is believed to be more effective in treating osteoarthritis than either ingredient alone.
How does Glucium-D work?
Glucium-D works by decreasing swelling and inflammation in the joints, as well as promoting cartilage repair and lubrication. Diacerein reduces the level of inflammation-causing molecules in the joints, while Glucosamine Sulphate helps to repair and regenerate cartilage. Together, these two ingredients can reduce pain, stiffness and inflammation associated with osteoarthritis.
Who should take Glucium-D?
Glucium-D is generally recommended for people over the age of 18 who have been diagnosed with osteoarthritis. It is important to consult with your doctor before taking any form of medication.
Is Glucium-D safe?
Yes, Glucium-D is generally considered safe when taken as directed. It is important to talk to your doctor before taking any kind of medication, as some people may be at a higher risk for experiencing side effects.
What are the side effects of Glucium-D?
The most common side effects of Glucium-D are stomach upset, diarrhea, nausea, and itching. In rare cases, people have reported experiencing some more serious side effects including shortness of breath, chest pain, and swelling of the face, hands, and feet.
How often should I take Glucium-D?
It is important to follow the dosing instructions given to you by your doctor. Most people are advised to take one or two capsules of Glucium-D, one or two times per day or as directed by their doctor.
Does Glucium-D have any interactions with other medications?
Yes, Glucium-D can interact with other medications. It is important to inform your doctor of all medications you are currently taking before starting Glucium-D.
Can I take Glucium-D while pregnant or breastfeeding?
It is not recommended to take Glucium-D during pregnancy or breastfeeding, as the safety of these medications has not been established in pregnant or breastfeeding women.
Can Glucium-D be used to treat other conditions?
Glucium-D is only approved to treat osteoarthritis. It has not been studied for the treatment of other conditions and should not be taken for any other purpose.
Can I take Glucium-D with alcohol?
It is not recommended to take Glucium-D with alcohol, as there is a potential for interaction. It is important to talk to your doctor before combining Glucium-D with any other substance, including alcohol.
How long does it take Glucium-D to work?
It typically takes 4 to 6 weeks for Glucium-D to show any improvements in symptoms. Some people may not notice any symptom improvements until after 12 weeks of taking these medications.
Are there any foods or activities I should avoid while taking Glucium-D?
It is important to talk to your doctor or pharmacist before taking this medication and avoid any known drug interactions. It is also recommended to avoid strenuous activities that may irritate the joints.
Does Glucium-D come in other forms?
No, Glucium-D is only available in capsule form.
Does Glucium-D have any contraindications?
Yes, Glucium-D has some contraindications. It is important to discuss any current medications or medical conditions with your doctor before taking this medication.
Can I take Glucium-D with other pain relief medications?
Yes, Glucium-D can be taken with other types of pain relief medications, however, it is important to talk to your doctor before taking any medications, as there may be interactions or contraindications.
What is the usual dosage of Glucium-D?
It is important to follow the dosage instructions given to you by your doctor. The usual starting dose is one or two capsules taken one or two times per day.
Is Glucium-D available over-the-counter?
No, Glucium-D is a prescription medication and must be prescribed by a doctor.
How long should I take Glucium-D for?
The duration of treatment depends on the severity of the condition and the response to treatment. It is important to talk to your doctor before stopping Glucium-D.
Does Glucium-D have any serious side effects?
In rare cases, Glucium-D can cause serious side effects such as shortness of breath, chest pain, and swelling of the face, hands, and feet. It is important to talk to your doctor right away if you experience any of these side effects.
Are there any alternatives to Glucium-D?
Other treatments for osteoarthritis include physical therapy, topical creams, oral non-steroidal anti-inflammatory drugs (NSAIDs), steroids, and joint replacement surgery. It is important to discuss all available treatments with your doctor before starting any form of treatment.
Can I take Glucium-D with other supplements?
It is important to talk to your doctor before taking any form of medication, including supplements with Glucium-D, as there may be interactions or contraindications.
How long does it usually take for Glucium-D to start working?
Most people start to feel some relief from their symptoms in 4 to 6 weeks after starting Glucium-D. It may take up to 12 weeks before the full effects of the medication have been realized.
What is the difference between Diacerein and Glucosamine Sulphate?
Diacerein is an anti-inflammatory medication that works by decreasing the amount of inflammation-causing molecules in the joints. Glucosamine Sulphate works by promoting cartilage repair and lubrication. Together, these two ingredients can reduce pain, stiffness, and inflammation associated with osteoarthritis.
Can I take Glucium-D with other anti-inflammatory medications?
It is important to talk to your doctor before taking any medications with Glucium-D, as there may be potential interactions or contraindications.
What are the most common side effects of Glucium-D?
The most common side effects of Glucium-D are stomach upset, diarrhea, nausea, and itching. It is important to talk to your doctor if any side effects are bothersome or persistent.
Will Glucium-D help reduce joint pain?
Yes, Glucium-D may help reduce joint pain associated with osteoarthritis. Most people start to experience some relief from pain and discomfort in 4 to 6 weeks after starting this medication.
Can I take Glucium-D if I have a shellfish allergy?
Yes, Glucium-D does not contain any shellfish and is safe to take even if you have a shellfish allergy.
Are there any dietary restrictions while taking Glucium-D?
No, there are no dietary restrictions while taking Glucium-D.
Should I take Glucium-D before or after meals?
It is best to take Glucium-D either before or after meals. Taking the medication with food may help reduce stomach upset.
Should I take Glucium-D with food or on an empty stomach?
It is best to take Glucium-D either before or after meals. Taking the medication with food may help reduce stomach upset.
Will Glucium-D help improve mobility?
Yes, Glucium-D can help improve joint mobility and flexibility. It is important to talk to your doctor if you are not seeing the desired results after 4 to 6 weeks.
Does Glucium-D have any interactions with other supplements?
It is important to talk to your doctor before taking any supplements with Glucium-D. There may be potential interactions or contraindications.
Can I take Glucium-D while taking other medications?
It is important to tell your doctor or pharmacist about all of the medications you are taking before starting Glucium-D. There may be potential interactions or contraindications.
Are there any foods or activities that I should avoid while taking Glucium-D?
It is important to discuss any current medications or medical conditions with your doctor before taking this medication. Additionally, it is recommended to avoid strenuous activities that may irritate the joints.
Can I take Glucium-D with other medications to treat pain?
It is important to talk to your doctor before taking any medications with Glucium-D, as there may be potential interactions or contraindications.
Will Glucium-D help improve the range of motion in my joints?
Yes, Glucium-D can help improve range of motion in the joints. It is important to talk to your doctor if you are not experiencing an improvement in your range of motion after 4 to 6 weeks of treatment.
Will Glucium-D help improve joint stiffness?
Yes, Glucium-D can help reduce pain and stiffness associated with osteoarthritis. Most people start to experience improvement in stiffness after 4 to 6 weeks of taking these medications.