Gliclazide Milpharm

Gliclazide Milpharm, a brand name for a formulation containing essential Gliclazide, is widely used for various health benefits. This guide provides comprehensive information on the uses, dosage, side effects, and mechanism of action of Gliclazide Milpharm, as well as insights into how long it takes to work. Understanding these aspects can help you make informed decisions about its use and effectiveness.

Introduction

Gliclazide Milpharm (also known as glyburide) is an oral anti-diabetic medication used to treat type 2 diabetes. It works by encouraging the release of insulin and lowering the blood sugar levels. It may also be used for other conditions as determined by your doctor.

Uses for

Gliclazide Milpharm is used to treat type 2 diabetes by helping to lower the blood sugar levels. It is usually prescribed after other diabetes medications have been tried without successful treatment of symptom.

Mechanism of Action

Gliclazide Milpharm works to treat type 2 diabetes by increasing the effect of insulin, which signals the body to lower the blood sugar level. It can help control glucose levels by increasing the release of insulin and reducing the amount of sugar produced by the liver.

How Long Does it Take to Work?

The duration of action of gliclazide is usually 6 to 12 hours, however it can take up to two weeks for it to reach its maximal effect.

Absorption

Gliclazide Milpharm is rapidly absorbed in the gastrointestinal tract. It is mainly absorbed in the small intestine, with some absorption in the stomach.

Route of Elimination

Gliclazide Milpharm is eliminated mainly through the kidneys. Approximately 70-90% of it is excreted unchanged in the urine.

Dosage

For adults, the recommended starting dose is 30-60mg once daily before the morning meal. The dose can be increased by 30-60mg every 1-2 weeks until the desired blood sugar levels have been achieved. It is important to take the same amount and time of dose each day.

Administration

Gliclazide Milpharm should be taken as directed by your doctor, usually once daily before a meal. It should be swallowed whole with a glass of water.

Side Effect

Gliclazide Milpharm can cause side effects such as nausea, vomiting, dizziness, headache, blurred vision, paleness, stomach pain, loss of appetite, diarrhea, lightheadedness, fatigue, and constipation.

Toxicity

Gliclazide Milpharm is considered to be a low toxicity medication. In case of overdose, symptomatic and supportive treatment should be provided.

Precautions

Gliclazide Milpharm can interact with other medications and increase the risk of side effects. It is important to tell your doctor about all the medications that you are taking before taking gliclazide.

Interaction

Gliclazide Milpharm can interact with other medications and increase the risk of side effects. It is important to tell your doctor about all the medications that you are taking before taking gliclazide.

Disease Interaction

Gliclazide Milpharm may interact with certain diseases and conditions such as liver, kidney, or heart disease; thyroid disorders; and asthma. It is important to tell your doctor about all of your medical conditions before taking gliclazide.

Drug Interactions

Gliclazide Milpharm may interact with other medications and increase the risk of side effects. It is important to tell your doctor about all the medications that you are taking before taking gliclazide.

Food Interactions

Gliclazide Milpharm can interact with certain foods and beverages and increase the risk of side effects. It is important to avoid foods high in sugar and fat while taking gliclazide.

Pregnancy Use

Gliclazide Milpharm should not be used during pregnancy. Consult your doctor about the potential risks and benefits of taking gliclazide during pregnancy.

Lactation Use

It is unknown whether gliclazide is excreted in breast milk. It is recommended to avoid taking gliclazide while breastfeeding.

Acute Overdose

In case of an acute overdose of gliclazide, symptomatic and supportive treatment should be provided.

Contraindication

Gliclazide Milpharm should not be used in patients with diabetic ketoacidosis, type 1 diabetes, type 3 diabetes, and in those allergic to it.

Use Direction

Gliclazide Milpharm should be taken exactly as prescribed by your doctor. Do not increase or decrease the dose, or take the medication for a longer period of time than prescribed.

Storage Conditions

Gliclazide Milpharm should be stored at room temperature, away from direct sunlight, heat and moisture. It should be kept out of the reach of children and pets.

Volume of Distribution

The volume of distribution of gliclazide is approximately 20-50 L/kg.

Half life

The elimination half-life of gliclazide is 1.5-4.5 hours.

Clearance

The clearance of gliclazide in adults is 0.15-0.3 ml/min/kg.

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