Geston

Geston Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Geston is a brand name. Its generic name is Allylestrenol.

Introduction

Geston (INN) is a synthetic steroidal progestin with antigonadotropic and antiglucocorticoid activity used as a treatment for recurrent miscarriage and threatened miscarriage.

Uses for

Geston is indicated for the prevention and treatment of recurrent and threatened miscarriages, and for the prevention of preterm labor.

Mechanism of Action

Geston is believed to act mainly through its estrogenic component. It promotes the development of the endometrium, enhancing the likelihood of successful implantation of a fertilized ovum. It also improves the strength of uterine contractions and exerts a sedative effect on the uterus and relaxes its smooth muscles.

How Long Does It Take to Work?

Geston begins to work immediately on administration, although its effects may not be fully manifest in the body until some weeks later. For example, if it is being used to reduce the risk of preterm labor, its effects may be seen within the week following administration.

Absorption

Geston is rapidly and completely absorbed from the gastrointestinal tract following oral administration.

Route of Elimination

Geston is metabolized primarily in the liver and excreted in the bile as metabolites. Approximately 40% of a dose of allylestrenol is excreted in the urine and 10% in the feces.

Dosage

The recommended starting dose of allylestrenol is 10 mg three times daily for three to six days. The dose may be increased up to 20 mg three times daily depending on the patient's response to treatment.

Administration

Geston is taken orally, usually with a full glass of water, after meals or at bedtime.

Side Effect

The most frequently reported side effects of allylestrenol include nausea, dizziness, bloating, and breast tenderness.

Toxicity

No cases of toxicity from allylestrenol have been reported.

Precautions

Geston should be used with caution in patients who have a history of liver or kidney disease, diabetes, or any other endocrine disorder. Women taking allylestrenol should not breastfeed while using the drug.

Interactions

Geston may interact with certain medications and reduce their effectiveness. Patients taking hormone replacement therapy, oral contraceptives, or anticoagulants should not take allylestrenol.

Disease Interactions

Geston should not be used in patients with a history of any of the following conditions: stroke, breast cancer, endometrial hyperplasia, or a history of jaundice or liver disease.

Drug Interactions

Geston may interact with certain medications and reduce their effectiveness. Patients taking hormone replacement therapy, oral contraceptives, or anticoagulants should not take allylestrenol. This drug should also not be used in combination with barbiturates, phenytoin, cyclosporine, or any other drug metabolized by CYP3A4 enzyme.

Food Interactions

It is not known if allylestrenol interacts with food. Patients should discuss diet and potential food interactions with their doctor prior to beginning treatment.

Pregnancy Use

Geston should not be used during pregnancy as it may cause harm to the fetus.

Lactation Use

It is not known if allylestrenol is excreted in breast milk. This drug should not be used while breastfeeding.

Acute Overdose

No cases of acute overdose of allylestrenol have been reported. However, if an overdose is suspected, contact a healthcare provider immediately.

Contraindication

Geston should not be used in patients with any of the following conditions: porphyria, thromboembolism, undiagnosed vaginal bleeding, or a history of breast or endometrial cancer.

Use Direction

Geston should be taken orally, usually with a full glass of water, after meals or at bedtime. The recommended starting dose is 10 mg three times daily for three to six days. The dose may be increased up to 20 mg three times daily depending on the patient's response to treatment.

Storage Condition

Geston should be stored at room temperature in a tight, light-resistant container. It should not be stored in the bathroom or near any heat source.

Volume of Distribution

The volume of distribution of allylestrenol is approximately 18 – 22 L/kg.

Half Life

The half-life of allylestrenol is estimated to range from 3.4 – 7.5 hours.

Clearance

The average clearance of allylestrenol is approximately 5.1 mL/min/kg.

Here you find in details version of Geston

Some Frequently Asked Questions About Geston

What is Geston?

Geston is a synthetic progestogen, or a man-made hormone, used in the treatment of threatened abortion and habitual abortion.

What is Geston used for?

Geston is used to prevent threatened miscarriage and habitual abortion in pregnant women. It is also used in combination with estrogen to treat secondary amenorrhea.

What is the dosage of Geston?

The usual dose of Geston is 5 mg to 10 mg a day. Dosage adjustments may be required depending on the individual patient’s condition.

What are the side effects of Geston?

The most common side effects of Geston include nausea, vomiting, abdominal pain, headaches, drowsiness, and diarrhea. Other serious side effects may include depression, skin rash, and facial swelling. If any of these side effects occur, seek medical attention right away.

Can Geston be used in combination with other medications?

Geston may interact with certain medications, so it should not be used in combination with other medications without consulting a doctor. Always make sure to tell your doctor about all medications that you are taking.

What precautions should be taken while consuming Geston?

Never take more than the prescribed dose of Geston. Also, if you are pregnant or planning to become pregnant, consult your doctor before using Geston. Be sure to tell your doctor if you are breastfeeding.

What are the contraindications for Geston?

Geston should not be used in people who are hypersensitive to this drug or any of its components. It should also not be used in people with a history of stroke or thromboembolic disease.

Is Geston available in generic form?

Yes, Geston is available in generic form.

What is the price of Geston?

The price of Geston varies depending on the pharmacy and where it is purchased. It is typically less expensive in generic form.

Is Geston available over the counter?

No, Geston is a prescription medication and is not available over the counter.

What is the mechanism of action of Geston?

Geston works by stopping the release of certain hormones that are responsible for triggering miscarriage and habitual abortion. It also helps to reduce the risk of premature delivery.

How long does it take for Geston to work?

The effects of Geston typically begin to be felt within one to two weeks of starting treatment. It is important to continue taking Geston as prescribed in order for it to be effective.

Can Geston be taken during pregnancy?

Yes, Geston can be used in pregnant women in order to prevent miscarriage and habitual abortion. However, it should not be used in the last three months of pregnancy without consulting a doctor.

Are there any known drug interactions with Geston?

Yes, Geston may interact with certain drugs, so it is important to tell your doctor about any medications or supplements you are taking before taking Geston.

Can Geston be taken with anticoagulant drugs?

No, Geston should not be taken with anticoagulant drugs without consulting a doctor first.

Can Geston be used in patients with liver or kidney diseases?

Yes, Geston may be used in patients with liver or kidney diseases, but the dose may need to be adjusted for these patients. Consult a doctor for more information.

Are there any foods that should be avoided with Geston?

There are no foods that should be avoided while taking Geston, however it is important to follow a healthy, balanced diet to ensure optimal health.

Can Geston cause weight gain?

Weight gain is not a common side effect of Geston, although some patients may experience an increase or decrease in appetite.

Does Geston affect fertility?

Geston has not been shown to affect fertility. However, it is important to consult a doctor if you are planning to become pregnant while taking Geston.

Can Geston cause sleep disturbances?

Yes, Geston can cause sleep disturbances, such as insomnia or vivid dreams. If this occurs, then consulting a doctor is recommended.

Can Geston cause mood changes?

Yes, Geston can cause mood changes, such as increased anxiety or depression. If this occurs, then consult a doctor.

Can Geston affect menstrual cycles?

Yes, Geston can affect menstrual cycles. This is because it prevents the body from releasing hormones that are responsible for triggering ovulation. It can also lead to irregular bleeding.

Can Geston cause headaches?

Yes, Geston can cause headaches in some patients. If you experience a persistent or severe headache while taking Geston, then consult a doctor.

Can Geston lower blood pressure?

Yes, Geston can lower blood pressure in some patients. It is important to monitor your blood pressure regularly while taking Geston.

Can Geston be used to treat breast cancer?

No, Geston should not be used to treat breast cancer. It is important to consult a doctor before taking any medication for breast cancer.

Is Geston linked to an increased risk of cancer?

No, Geston is not linked to an increased risk of cancer. However, it is important to consult a doctor if you are concerned about the potential risk of cancer while taking Geston.

Does Geston affect the liver?

Yes, Geston can affect the liver in some patients. It is important to monitor your liver functions regularly while taking Geston.

Can Geston be used in women of childbearing age?

Yes, Geston can be used in women of childbearing age, but it should not be used for the treatment of pregnancy unless specifically prescribed by a doctor.

Can Geston cause skin rashes?

Yes, Geston can cause skin rashes in some patients. If you experience any skin rashes while taking Geston, then consult a doctor for treatment.

Can Geston affect libido?

Yes, Geston can have an effect on libido in some patients. Consult a doctor if you are experiencing any changes in your libido while taking Geston.

Does Geston affect the heart?

Yes, Geston can affect the heart in some people. It is important to inform your doctor if you have any heart-related conditions before taking Geston.

Does Geston accumulate in the body?

No, Geston is not known to accumulate in the body. This means that it is not necessary to adjust the dosage of Geston based on the amount of time it has been taken.

Is Geston an anti-inflammatory drug?

No, Geston is not an anti-inflammatory drug. It is a synthetic progestogen used for the prevention of miscarriage and habitual abortion.

Can Geston be used to induce labor?

No, Geston should not be used to induce labor unless specifically prescribed by a doctor.

Can Geston cause drowsiness?

Yes, Geston can cause drowsiness in some patients. It is important to be aware of how Geston affects you before operating any machinery or driving a vehicle.

Does Geston cause hair loss?

No, Geston does not cause hair loss. However, it is important to consult a doctor if you experience any unusual hair loss while taking Geston.

Can Geston cause breast tenderness?

Yes, Geston can cause breast tenderness in some patients. If this occurs, then consult a doctor.

Can Geston be taken while breastfeeding?

Yes, Geston can be taken while breastfeeding, but it is important to inform your doctor if you are breastfeeding while taking Geston.

Can Geston cause visual disturbances?

Yes, Geston can cause visual disturbances, such as blurred vision or double vision. If this occurs, then consult a doctor.

Does Geston cause nausea?

Yes, Geston can cause nausea in some patients. If you experience persistent or severe nausea while taking Geston, then consult a doctor.