Gentabac HC
Gentabac HC Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Gentabac HC is a brand name. Its generic name is Gentamicin + Hydrocortisone Acetate.
Introduction & Uses
Gentabac HC is a combination of two medicines. Gentamicin is an antibiotic which works by killing bacteria. Hydrocortisone acetate is a steroid which works by reducing inflammation and swelling. This combination medication is used to treat bacterial infections of the eye or ear that are accompanied by inflammation and/or swelling.Mechanism of Action
The combination of gentamicin and hydrocortisone further enhances the therapeutic efficacy of the medication by the actions of the individual components. Gentamicin is an aminoglycoside antibiotic which works by binding to a site on the 30S ribosomal subunit of bacterial cells in order to inhibit protein synthesis and killing bacteria. Hydrocortisone acetate is a type of corticosteroid which works by inhibiting the release of inflammatory mediators like histamine and leukotrienes and causes anti-inflammatory effects and reduces swelling.How Long Does it Take to Work?
The effects of Gentabac HC start appearing within a few hours. Depending on the severity of the infection and individual response, one may need to take multiple doses over a period of time for the desired results.Absorption, Route Of Elimination & Dosage
Gentabac HC is a topical application and hence the medicine is absorbed through the skin. The medicine is eliminated through the metabolism in the body. The dose of this combination medication depends on the individual's condition. A physician should be consulted to determine the most appropriate dose.Administration & Side Effects
Gentabac HC is administered either as drops or ointment in the affected area depending on the severity and doctor's instruction. Common side effects of using this medication include pain, burning sensation, itching, stinging, light sensitivity, redness and dryness on the affected area.Toxicity & Precautions
Toxicity is not significant when gentamicin and hydrocortisone are used in reasonable doses. If used for prolonged periods, the body may become susceptible to the effects of the medications. The topical application should not be used on broken skin or near the eyes. The affected area should not be exposed to strong sunlight or heat as this can aggravate the symptoms. In case of any adverse effects, consult a physician immediately.Interactions
Gentabac HC may interact with certain medications and other substances, such as alcohol. Therefore, it is always advisable to consult a physician before taking this combination medication.Disease Interactions, Drug Interactions, Food Interactions, Pregnancy Use, Lactation Use, Acute Overdose & Contraindication
Gentabac HC may interfere with the absorption and/or effects of certain medicines, and is contraindicated in patients with known hypersensitivity to the medication. It is generally not recommended in pregnant and lactating women except on doctor's advice. Consumption of alcohol should be avoided while taking this medication. In case of accidental overdose, medical advice should be sought immediately.Use Direction & Storage Condition
This medication should be used as per the directions given in the patient information leaflet or as directed by the physician. The ointment or drops should be stored below 25°C in a cool dry place and away from direct sunlight.Volume of Distribution, Half Life, Clearance
Gentamicin (the active ingredient in Gentabac HC) has a volume of distribution of 0.096-1.17 litres/kg. The half-life of gentamicin is 2-3 hours. The clearance of this medication is approximately 0.75ml/min/kg.Here you find in details version of Gentabac HC