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জেনাজপ্ট (চোখের ড্রপ)

By General Pharmaceuticals Ltd.

Weight: 1%+0.5%

Unit Price: 700

Last Updated: 2019-11-05 09:25:23

জেনাজপ্ট চোখের ড্রপ এর কাজ

Treatment of elevated IOP in adult patients with open-angle glaucoma or ocular HTN for whom monotherapy provides insufficient IOP reduction.

জেনাজপ্ট জেনারিক

Brinzolamide + Timolol

জেনাজপ্ট পরিচিতি

Brinzolamide is a highly specific inhibitor of CA-II, which is the main CA isoenzyme involved in the secretion of aqueous humor. Inhibition of CA in the ciliary process of the eye slows the formation of bicarbonate, and reduces sodium and fluid transport. This results in a reduction in the rate of aqueous humor secretion and the intraocular pressure. Brinzolamide is absorbed systemically following topical ocular administration. Since it has a high affinity for CA-II, brinzolamide binds extensively to red blood cells, where CA-II is primarily found. As sufficient CA-II activity remains, adverse effects resulting from the systemic inhibition of CA by brinzolamide are not observed. The metabolite N-desethyl brinzolamide is also formed. This metabolite binds to CA and accumulates in red blood cells as well. In the presence of brinzolamide, the metabolite binds mainly to carbonic anhydrase I (CA-I).

Like propranolol and nadolol, timolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle and beta(2)-receptors in the bronchial and vascular smooth muscle. Beta(1)-receptor blockade results in a decrease in resting and exercise heart rate and cardiac output, a decrease in both systolic and diastolic blood pressure, and, possibly, a reduction in reflex orthostatic hypotension. Beta(2)-blockade results in an increase in peripheral vascular resistance. The exact mechanism whereby timolol reduces ocular pressure is still not known. The most likely action is by decreasing the secretion of aqueous humor.

জেনাজপ্ট চিকিত্সাবিদ্যাগত শ্রেণী

Drugs for miotics and glaucoma

জেনাজপ্ট চোখের ড্রপ খাওয়ার নিয়ম

1 drop into the affected eye(s) twice daily

জেনাজপ্ট এর প্রয়োগ-পদ্ধতি

জেনাজপ্ট চোখের ড্রপ এর পার্শ্বপ্রতিক্রিয়া

Dysgeusia, blurred vision, eye pain & irritation, foreign body sensation.

জেনাজপ্ট ব্যবহারে সতর্কতা

 

জেনাজপ্ট এর প্রতিক্রিয়া

Ketoconazole, itraconazole, clotrimazole, ritonavir, troleandromycin; oral Ca-channel blockers, guanethidine, β-blockers, antiarrhythmics, digitalis glycosides, parasympathomimetics; quinidine, cimetidine.

জেনাজপ্ট গর্ভকালীন কিংবা দুগ্ধদানকালীন অবস্থায় ব্যবহার

Control cardiac failure prior to therapy. History of severe cardiac & resp disease. Patients subject to hypoglycemia or labile insulin-dependent diabetes. May mask hyperthyroidism or worsen Prinzmetal's angina, severe peripheral & central circulatory disorders & hypotension. History of atopy or severe anaphylactic reaction to a variety of allergens. Avoid concomitant use of 2 local β-adrenergic blockers or 2 local carbonic anhydrase inhibitors. Close monitoring of IOP in patients with pseudoexfoliative or pigmentary glaucoma. Narrow-angle glaucoma. Monitor patients with compromised corneas eg, patients with DM or corneal dystrophies. Remove contact lenses prior to application; reinsert after 15 min. May impair ability to drive or operate machinery. Pregnancy. Childn <18 yr.

জেনাজপ্ট মাত্রাতিরিক্ত সেবনের প্রতিক্রিয়া

 

জেনাজপ্ট এর প্রতিনির্দেশনা

Bronchial asthma, severe COPD, sinus bradycardia, 2nd or 3rd degree AV block, overt cardiac failure, cardiogenic shock, severe allergic rhinitis, bronchial hyperreactivity, hyperchloraemic acidosis, severe renal impairment.

জেনাজপ্ট এর ব্যবহারবিধি

 

জেনাজপ্ট সংরক্ষণ

Store in cool and dry place

জেনাজপ্ট এর বিশেষ সতর্কতা

 

জেনাজপ্ট এর অন্যান্য ঔষধের সাথে প্রতিক্রিয়া