Genazopt

Genazopt Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Genazopt is a brand name. Its generic name is Brinzolamide + Timolol.

Introduction

Brinzolamide and Timolol are a combination drug used to treat certain eye conditions, including glaucoma and ocular hypertension. This medication helps to reduce the production of intraocular fluids and thus, keeps the pressure within the eye at a normal level. The combination drug works as a prodrug, i.e. it is converted in the body to its active form, and has been approved by the FDA in July, 2015.

Uses

Brinzolamide and timolol is used to treat ocular hypertension and open-angle glaucoma, when other medications are not effective. It works by reducing the production of intraocular fluids, thereby reducing the intraocular pressure within the eye.

Mechanism of Action

The combination of brinzolamide and timolol works as a prodrug and is converted in the body to its active form. Brinzolamide is an inhibitor of carbonic anhydrase, an enzyme that is responsible for the production of intraocular fluids. Timolol is a beta blocker that blocks the beta receptors, which are responsible for the production of fluids in the eye. Thus, the combination of these two medications helps reduce the production of bimolecularly fluid in the eye, resulting in a decrease in intraocular pressure.

How long does it take to work?

The effects of the combination drug typically occur within 30 minutes of administering it.

Absorption

Brinzolamide and timolol are both taken orally and rapidly absorbed into the bloodstream. However, they are in the form of a prodrug in the body and must be converted into their active form before they can be effective.

Route of Elimination

Brinzolamide is primarily eliminated through the urine, while timolol is largely eliminated through the feces.

Dosage

The recommended dose of brinzolamide and timolol is one drop of the combination drug in each eye, three times daily. It is important to follow the instructions of your healthcare provider, and you should not adjust your dosage without consulting your healthcare provider.

Administration

Firstly, wash your hands with soap and water. Tilt your head back and gently pull your lower eyelid down to create a pouch. Hold the dropper above the eye with the other hand. Apply one drop of brinzolamide and timolol to the inside of the lower eyelid. Look downwards and close your eye for 2-3 minutes, allowing the medication to spread in the eye. Wipe away any excess liquid from around your eye using a tissue.

Side Effects

Common side effects of brinzolamide and timolol may include vision changes, dry eye, sore throat, headache, dizziness, weakness, burning or stinging sensation in the eye, and redness in the eye.

Toxicity

The combination of brinzolamide and timolol is thought to be non-toxic. However, it should not be used in patients with a known hypersensitivity to either medication.

Precautions

Before administering brinzolamide and timolol, tell your doctor or healthcare provider if you are allergic to any of the ingredients in the drug, or if you have any other allergies. This medication may cause blurred vision. It is important to use caution when driving or performing any activities in which clear vision is necessary. Also, tell your healthcare provider about other medications that you are taking, as there may be some drug interactions that may occur when taking this combination drug.

Interactions

Brinzolamide and timolol may interact with other medications, including certain antibiotics, antifungals, antidepressants, anticonvulsants, and certain blood pressure medications. It is important to discuss all medications and supplements with your healthcare provider before starting this medication.

Disease Interaction

Brinzolamide and timolol should not be used in patients who have a known history of bronchial asthma, emphysema, COPD, or any other chronic obstructive pulmonary disease, as this combination may worsen their condition. Additionally, it should be used with caution in patients with severe cardiovascular or hepatic disease.

Drug Interactions

Brinzolamide and timolol may interact with certain drugs, including certain antibiotics, antifungals, antidepressants, anticonvulsants, and certain blood pressure medications. Before starting this medication, it is important to discuss all medications and supplements with your healthcare provider.

Food Interactions

There are no known food interactions with brinzolamide and timolol.

Pregnancy Use

Brinzolamide and timolol should be used with caution during pregnancy, as it may cause harm to unborn babies. Tell your doctor if you are pregnant or planning to become pregnant while taking this medication.

Lactation Use

There is no known information regarding the safety of brinzolamide and timolol use during lactation. As a precaution, it is advisable to avoid this combination drug while nursing an infant.

Acute Overdose

In case of overdose, seek emergency medical attention. Overdose symptoms may include blurred vision, dizziness, dry mouth, drowsiness, nausea, vomiting, and rapid heart rate.

Contraindication

Brinzolamide and timolol should not be used in patients who have a known hypersensitivity to either medication. It should also not be used in patients with a known history of bronchial asthmas, COPD, or any other chronic obstructive pulmonary disease.

Use Direction

The recommended dose of brinzolamide and timolol is one drop of the combination drug in each eye, three times daily. It is important to follow the instructions of your healthcare provider, and you should not adjust your dosage without consulting your healthcare provider.

Storage Condition

This medication should be stored between 20°C (68°F) and 25°C (77°F), protected from light and moisture.

Volume of Distribution

The volume of distribution of brinzolamide and timolol is unknown.

Half Life

The half life of both brinzolamide and timolol is unknown.

Clearance

The clearance rate of brinzolamide and timolol is unknown.

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