Genazopt Plus

Genazopt Plus Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Genazopt Plus is a brand name. Its generic name is Brinzolamide + Brimonidine.

Introduction

Genazopt Plus is a combination eye drop that's used to treat certain types of glaucoma and ocular hypertension. It consists of brinzolamide, a carbonic anhydrase inhibitor, and brimonidine, a sympathomimetic agent. The combination of the two medications works to reduce intraocular pressure by reducing aqueous flow and increasing outflow.

Uses For

Genazopt Plus is mainly prescribed for the treatment of open angle glaucoma and ocular hypertension. It may also be prescribed to treat other conditions where increases in intraocular pressure are present.

Mechanism of Action

Genazopt Plus work by reducing aqueous production and enhancing uveoscleral outflow. Brinzolamide inhibits the enzyme carbonic anhydrase, which results in decreased production of aqueous humor. Brimonidine acts by stimulating the alpha-2 receptors which lead to vasoconstriction of the blood vessels around the eye and an increase in the ocular outflow facility. The combination of both medications results in a decrease in intraocular pressure.

How Long Does It Take to Work

The effects of Genazopt Plus generally take approximately two hours to reach peak effectiveness. In some individuals, it may take even longer.

Absorption

Genazopt Plus is generally well absorbed through the cornea, reaching the anterior chamber via tear film. It is then distributed into the anterior chamber and reaches peak levels within two hours of administration.

Route of Elimination

Both brimonidine and brinzolamide are mainly eliminated through the kidneys.

Dosage

The recommended dose for Genazopt Plus is one drop to be instilled in the affected eye(s), twice daily. It is important to follow the instructions of your ophthalmologist for the best results.

Administration

Genazopt Plus should be instilled in the lower conjunctival sac of the affected eye(s) twice daily, 12 hours apart. It is important to observe proper sterile technique when administering the medication. After instillation, the eye should be closed for several minutes to allow the medication to spread across the surface.

Side Effects

Common side effects of Genazopt Plus may include but are not limited to blurred vision, dry eyes, eye irritation, headaches, and tearing. In rare cases, serious side effects such as rash and vision changes may occur.

Toxicity

Genazopt Plus is considered to be generally safe and well tolerated when taken as directed. Overdose symptoms may include vision changes, headaches, and vomiting. In that case, seek immediate medical attention.

Precaution

It is very important to follow the instructions of your ophthalmologist when taking Genazopt Plus. Before taking the medication, inform your doctor if you have any allergies or if you are pregnant or nursing.

Interaction

Genazopt Plus may interact with other medications, such as beta blocking agents, acetazolamide, and tricyclic antidepressants. Consult your doctor or pharmacist for more information.

Disease Interaction

Genazopt Plus may interact with certain diseases, such as cardiovascular disease, liver disease, renal failure, cataracts, and diabetes. Consult your doctor before taking the medication.

Drug Interaction

Genazopt Plus may interact with certain drugs, such as beta blockers, tricyclic antidepressants, and ACE inhibitors. Consult your doctor or pharmacist for more information.

Food Interactions

Genazopt Plus may interact with certain foods, such as alcohol. Consult your doctor before taking the medication.

Pregnancy Use

Genazopt Plus is not recommended for use during pregnancy.

Lactation Use

Genazopt Plus is not recommended for use while breastfeeding.

Acute Overdose

In case of an acute overdose, seek emergency medical attention. Symptoms of overdose may include vision changes, headaches, and vomiting.

Contraindication

Genazopt Plus is contraindicated in individuals who are hypersensitive to any of the ingredients of the product.

Use Direction

Genazopt Plus should be administered as instructed by your ophthalmologist. The recommended dose is one drop to be instilled in the affected eye(s), twice daily, 12 hours apart. After instillation, the eye should be closed for several minutes to allow the medication to spread across the surface.

Storage Condition

Genazopt Plus should be stored at room temperature, away from light and moisture. In addition, it should be kept out of the reach of children and pets.

Volume of Distribution

The volume of distribution of Genazopt Plus is unknown.

Half Life

The half life of brinzolamide is 2.9 hours, while the half life of brimonidine is 3 hours.

Clearance

The clearance of brinzolamide is 268 ml/min/kg, while the clearance of brimonidine is 365 ml/min/kg.

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