Gemfibrozil, a brand name for a formulation containing essential Gemfibrozil, is widely used for various health benefits. This guide provides comprehensive information on the uses, dosage, side effects, and mechanism of action of Gemfibrozil, as well as insights into how long it takes to work. Understanding these aspects can help you make informed decisions about its use and effectiveness.


Gemfibrozil is a prescription medication used to reduce cholesterol levels and treat hypertriglyceridemia (high levels of triglycerides in the blood). It belongs to a class of drugs called fibrates which can help to decrease triglycerides, increase "good" cholesterol (HDL) and slow the buildup of fatty substances in the arteries.


Gemfibrozil is approved by the U.S Food and Drug Administration to be used in adults to lower triglyceride levels and/or total cholesterol levels. It is used in combination with diet to reduce the risk of coronary heart disease and associated symptoms such as heart attack and stroke. The drug may be used to control levels of non-HDL cholesterol and lipoprotein(a).

Mechanism of Action

Gemfibrozil works by affecting the metabolism of certain fats and lipids released by the liver. It helps to reduce the production of triglycerides, raise the level of “good” cholesterol (HDL) and prevent the build-up of fatty substances in the arteries.

How Long Does it Take to Work?

Gemfibrozil typically starts to work within 2-4 weeks after it is started. It is important to follow a low-fat diet and other lifestyle changes while taking the medication to see the desired effects.


Gemfibrozil is well absorbed from the gastrointestinal tract after oral administration, with peak plasma concentrations occurring at 2-4 hours. The oral bioavailability of this drug is very high, with about 98% of an oral dose being absorbed.

Route of Elimination

Gemfibrozil is eliminated mainly through the feces. About 90% of the dose is excreted in the feces, with the remainder excreted in the urine.

Dosage and Administration

The recommended dose of Gemfibrozil for adults 18 years and older is 600 mg taken orally twice daily, one hour before or two hours after meals. It can be taken with or without food, but should not be eaten with high-fat meals or grapefruit juice.

Side Effects

Gemfibrozil can cause side effects such as stomach pain, heartburn, decreased appetite, nausea, diarrhea, and constipation. It can also cause rash, muscle aches, fever, increased liver enzymes, and increased cholesterol levels.


Gemfibrozil should not be used in people with active liver disease or in individuals with a known hypersensitivity to fibrates. This medication should also be used with caution in people with a history of kidney or gallbladder disease.


Gemfibrozil can interact with other medications used to lower cholesterol, anticoagulants, acetaminophen, theophylline, and atorvastatin. Always tell your doctor about all the medications you are taking.

Food Interactions

Gemfibrozil can interact with certain foods, such as grapefruit juice, which should be avoided.

Pregnancy and Lactation

Gemfibrozil is classified as a category C drug which means that it should not be used during pregnancy as it may cause harm to the fetus. It is also not recommended to be used during breastfeeding.

Acute Overdose

Signs and symptoms of an overdose of Gemfibrozil include nausea, vomiting, stomach pain, diarrhea, dizziness, and confusion. Seek immediate medical attention if you experience any of these symptoms.


Gemfibrozil is contraindicated for use in people with active liver disease or in individuals with a known hypersensitivity to fibrates.

Use Direction

Take Gemfibrozil exactly as prescribed by your doctor. Follow all directions on the prescription label. Do not take this medicine in larger or smaller amounts than prescribed.

Storage Conditions

Gemfibrozil should be stored at room temperature between 15°C and 30°C and protected from light and moisture. Do not store this medication in the bathroom.

Volume of Distribution

The volume of distribution of Gemfibrozil is approximately 1.8 L/kg.

Half Life

The average half-life of Gemfibrozil is about 5-14 hours.


The clearance of Gemfibrozil is about 0.7 L/hr/kg.

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