Gazyva
Gazyva Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Gazyva is a brand name. Its generic name is Obinutuzumab.
Introduction
Gazyva (also known as Gazyva) is a type of monoclonal antibody given to treat certain types of cancer, including chronic lymphocytic leukemia (CLL). It works by binding to a protein called CD20 which is found on the surface of certain types of B-cells. When bound to CD20, it can cause the B-cells to break down and die.
Uses
Gazyva is used to treat advanced and relapsed forms of chronic lymphocytic leukemia (CLL). It is administered with fludarabine and cyclophosphamide in combination, or with bendamustine as monotherapy.
Mechanism of Action
Gazyva works by binding to a protein called CD20 found on the surface of B-cells, marking them for destruction by the body's immune system. The drug also enhances the activation of other immune cells that help kill cancer cells, including natural killer cells, macrophages, and T-cells.
How Long Does It Take to Work?
Gazyva usually takes 7-10 days to start working. The drug works best when it is given on an ongoing basis, so it's important to stick with the treatment plan prescribed by your doctor.
Absorption
Gazyva is rapidly absorbed from the subcutaneous tissue after administration and has an elimination half-life of approximately 11 days.
Route of Elimination
Gazyva is eliminated by the kidneys. Its metabolites and breakdown products may be eliminated by the liver.
Dosage
Gazyva is usually given in a series of 6 weekly injections, or as an infusion over a period of several hours. The dose and duration of therapy will depend on the type of cancer being treated and the patient's overall health.
Administration
Gazyva is usually given as a subcutaneous injection, or an IV infusion over a period of several hours. Subcutaneous injections are given into the fatty layer of the skin below the surface of the skin. For IV infusions, the drug is given via a catheter placed into an artery or vein in the arm.
Side Effects
Common side effects of Gazyva include flu-like symptoms, urinary tract infections, fatigue, low energy, fever, chills, nausea, headache, diarrhea, injection site reactions, and rash. Serious side effects can include infusion reactions, kidney problems, and an increased risk of infection.
Toxicity
Gazyva is generally well-tolerated, but the drug can cause serious side effects. Patients should always discuss possible risks and side effects with their doctor before starting treatment.
Precautions
Patients taking Gazyva should receive regular medical check-ups and blood tests to monitor for any possible side effects. Patients should also notify their doctor if they experience any changes in their health or any signs of infection or illness.
Interactions
Gazyva may interact with certain medications or supplements, so it is important to inform your doctor of any medications or supplements that you are taking.
Disease Interactions
Gazyva may interact with certain diseases or conditions. It should not be used in patients who have had a severe allergic reaction to another similar medication or who have an active infection.
Drug Interactions
Gazyva may interfere with the effects of other drugs. It is important to tell your doctor about any other medications you are taking. This includes prescription and over-the-counter medications, as well as vitamins, supplements, and herbal remedies.
Food Interactions
Gazyva should not be taken with grapefruit or grapefruit juice, as this may increase the risk of side effects. It is also important to drink plenty of fluids while taking Gazyva to prevent dehydration.
Pregnancy and Lactation Use
It is not known if Gazyva is safe to use during pregnancy or while breastfeeding. Pregnant women and women who are breastfeeding should discuss the risks and benefits of taking Gazyva with their doctor before beginning treatment.
Acute Overdose
If you or someone else experiences an overdose with Gazyva, it is important to seek medical attention immediately. Overdose symptoms may include difficulty breathing, dizziness, changes in vision, and nausea.
Contraindication
Gazyva should not be used in patients who have had a severe allergic reaction to another similar medication or who have an active infection. Surgery or any other elective procedure should be postponed until after treatment with Gazyva is complete.
Use Direction
Gazyva should be taken as prescribed by your doctor. It is usually given in a series of 6 weekly injections or as an infusion over a period of several hours. Follow your doctor's instructions for the best results.
Storage Condition
Gazyva should be stored in a refrigerator (2°C-8°C) and protected from light. Any unused or expired product should be disposed of properly according to your doctor's instructions.
Volume of Distribution
The volume of distribution for Gazyva depends on the dose and route of administration of the drug. The volume of distribution for a subcutaneous dose is approximately 131-178 L, whereas for an IV dose it is approximately 53-106 L.
Half Life
The average half-life of Gazyva is approximately 11 days. This means that the drug is slowly eliminated from the body over time.
Clearance
The clearance of Gazyva is slow and non-linear. It is eliminated from the body mainly by the kidneys.
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