Fusidate
Fusidate Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Fusidate is a brand name. Its generic name is Sodium Fusidate.
Fusidate
Sodium fusidate, or sodium fusidate, is an antibiotic of the fusidic acid class used to treat certain bacterial infections. It is used in the treatment of skin infections, serious streptococcal and staphylococcal infections, and systemic infections. It is also used to treat sequelae of diphtheria infections, chronic bronchitis, and other respiratory infections.
Uses
Sodium fusidate is used to treat infections caused by staphylococci (Staphylococcus aureus, Streptococcus pneumoniae), Haemophilus influenzae, Moraxella catarrhalis, and certain other bacteria.
Mechanism of Action
Sodium fusidate exerts its bactericidal action by inhibiting the bacterial protein synthesis. It binds to the bacterial 23S ribosomal RNA of the 50S subunit and inhibits peptide bond formation.
How long does it take to work?
Sodium fusidate typically begins to work within 1-2 days of taking it. Improvement in symptoms such as itching, redness, swelling and pain should be noticed during the first few days of treatment.
Absorption
Sodium fusidate is completely absorbed by the gastrointestinal tract after oral administration.
Route of Elimination
Sodium fusidate is eliminated mainly through the kidneys.
Dosage
The recommended adult dosage of sodium fusidate for infections caused by susceptible organisms is 500 mg every 12 hours. The dose may be increased to 1000 mg every 12 hours if necessary. For skin infections, the recommended dosage is 250 mg twice daily for seven days.
Administration
Sodium fusidate is usually taken orally, though it can also be given intravenously in some cases. It should be taken with food to lessen gastrointestinal discomfort.
Side Effect
Common side effects of sodium fusidate include nausea, vomiting, abdominal pain, dizziness, headache, itching, rash, metallic taste, and diarrhea. Other more serious side effects include allergic reactions, tendon inflammation, and renal dysfunction.
Toxicity
No toxicity studies have been conducted with sodium fusidate. It is thought to be safe in therapeutic doses, but toxicities such as vomiting, abdominal pain, and dizziness may occur with higher doses.
Precaution
Patients taking sodium fusidate should be regularly monitored for signs of adverse reactions. The antibiotic should be used with caution in patients with hepatic or renal disorders and those taking other medications that may interact with sodium fusidate.
Interaction
Sodium fusidate may interact with other medications, including certain antibiotics, anticoagulants, and anticonvulsants. It is also important to inform a doctor of any other medications being taken before starting treatment with sodium fusidate.
Disease Interaction
Sodium fusidate may not be suitable for all patients. Patients should inform their doctor of any other medical conditions they have before taking sodium fusidate, such as hepatic or renal disease, as these may interact with the antibiotic.
Drug Interaction
Sodium fusidate can interact with other medications, including certain antibiotics, anticoagulants, and anticonvulsants. It is important to notify a doctor of any other medications a patient may be taking before starting treatment with sodium fusidate.
Food Interactions
There are no known food interactions with sodium fusidate.
Pregnancy Use
Sodium fusidate should be used with caution by pregnant women as it may cause fetal harm. It should not be used if it is known that the baby will have an allergic reaction to sodium fusidate.
Lactation Use
Sodium fusidate is excreted in breast milk and may cause adverse reactions in nursing infants, including diarrhea, loose stools, vomiting, and rash. Mothers should avoid using this medication while breastfeeding.
Acute Overdose
Patients who ingest more than the recommended dose should seek medical attention immediately. Symptoms of an acute overdose may include nausea, vomiting, abdominal pain, dizziness, and hypotension.
Contraindication
Sodium fusidate should be avoided in patients who are allergic to it, as well as those with liver or kidney impairment.
Use Direction
Sodium fusidate should be taken as directed by a doctor. The usual adult dose of sodium fusidate is 500 mg every 12 hours. For skin infections, the recommended dosage is 250 mg twice daily for seven days.
Storage Condition
Sodium fusidate should be stored in a cool, dry place, away from direct light. It should be kept out of reach of children.
Volume of Distribution
Sodium fusidate has an estimated volume of distribution of 1.7 L/kg.
Half Life
Sodium fusidate has an estimated half-life of 1-2 hours.
Clearance
Sodium fusidate has an estimated renal clearance of 4-5 ml/min/kg.
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