Fulvicin P/G

Fulvicin P/G, a brand name for a formulation containing essential Griseofulvin, is widely used for various health benefits. This guide provides comprehensive information on the uses, dosage, side effects, and mechanism of action of Fulvicin P/G, as well as insights into how long it takes to work. Understanding these aspects can help you make informed decisions about its use and effectiveness.

Introduction

Fulvicin P/G is an antifungal drug designed to treat various fungal infections in humans. It is derived from a species of Penicillium mold, first isolated in 1926. Its ability to penetrate and treat fungal infections in the skin, hair, and nails made it an effective treatment of certain types of ringworm and other fungal infections.

Uses

Fulvicin P/G is used to treat a variety of fungal infections, including ringworm, jock itch, athlete’s foot, onychomycosis (a fungal infection of the fingernails and/or toenails), and several other fungal skin infections. It has also been used to treat fungal infections of the nails and scalp.

Mechanism of Action

Fulvicin P/G works by inhibiting the mitotic division of fungal cells. By preventing the cells from dividing, the fungus cannot spread. Additionally, griseofulvin disrupts the cell membrane lipid content, weakening the cell walls and further inhibiting cell proliferation.

How long does it take to work?

Fulvicin P/G typically takes about seven to ten days before noticeable improvement of the fungal infection is seen. However, treatment can continue for up to three months, or whatever is prescribed by the doctor. The severity and location of the infection and how well the patient follows the regimen will influence treatment success.

Absorption

Fulvicin P/G is poorly absorbed from the gastrointestinal tract. It is best absorbed when taken with food containing fatty acids and must be taken with meals or snacks that contain fat.

Route of Elimination

Fulvicin P/G is primarily eliminated from the body in urine and feces.

Dosage

The typical adult dose of griseofulvin is 500 to 1000mg per day in divided doses. The total dose should be taken for 2 to 4 weeks or longer depending upon the condition being treated. For fungal nails, treatment may be as long as 3 to 6 months. The dose may be adjusted depending upon renal and hepatic function. Children should take 10 to 20 mg/kg/day in divided doses for 2 to 4 weeks.

Administration

Fulvicin P/G should be taken orally with meals or snacks containing fat for optimal absorption.

Side Effects

The most common side effects of griseofulvin include nausea, vomiting, headache, abdominal discomfort, diarrhea, rash, hives, and itching.

Toxicity

The toxic effects of griseofulvin are rare. However, overdose of this medication may cause depression, confusion, lethargy, and visual disturbances.

Precaution

Fulvicin P/G should be used with caution in patients with renal and hepatic impairment, as well as in those with a history of drug allergies. Patients should also be advised to avoid drinking alcohol while taking this medication.

Interactions

Fulvicin P/G interacts with several medications, including anticoagulants, antidepressants, antiepileptic drugs, and anticancer medications. It is important to check with your doctor or pharmacist for any potential drug interactions.

Disease Interaction

Fulvicin P/G may interact with certain diseases, such as hepatic or renal impairment, myasthenia gravis, and porphyria.

Drug Interactions

Fulvicin P/G may interact with several other medications, such as anticoagulants, antidepressants, antiepileptic drugs, and anticancer medications. It is important to check with your doctor or pharmacist for any potential drug interactions.

Food Interactions

Fulvicin P/G should not be taken with grapefruit or grapefruit juice, as it may increase the risk of side effects.

Pregnancy Use

Fulvicin P/G should be used with caution and only if clearly needed during pregnancy. It is not known whether this drug passes into breast milk.

Lactation Use

Fulvicin P/G should not be used in nursing mothers unless specifically indicated by the doctor.

Acute Overdose

The effects of an acute overdose can vary depending on the amount taken. Symptoms may include nausea, vomiting, dizziness, drowsiness, and blurred vision.

Contraindication

Fulvicin P/G should not be used in patients with a history of hypersensitivity to any of its constituents.

Use Direction

Fulvicin P/G should be taken as prescribed by your doctor or healthcare provider. The dose should be taken on an empty stomach with a full glass of water and should be taken with meals or snacks containing fat.

Storage Condition

Fulvicin P/G tablets should be stored in a cool, dry place, away from direct sunlight. It is recommended to store this medication in its original container.

Volume of Distribution

Fulvicin P/G is widely distributed in the body tissues and fluids. The estimated volume of distribution is between 2 and 3 L/kg.

Half Life

Fulvicin P/G has a long half-life that ranges from 12 to 24 hours and can be increased in the presence of liver disease.

Clearance

Fulvicin P/G is metabolized by the liver and is eliminated through the kidneys. The estimated clearance is 2.4 mL/min/kg.

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