Fibrostat

Fibrostat Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Fibrostat is a brand name. Its generic name is Tranexamic Acid.

Introduction

Fibrostat (TXA) is an antifibrinolytic agent that is used to reduce the clotting of blood and reduce bleeding. It is used to treat and prevent excessive menstrual bleeding in women, and to treat bleeding following trauma, surgery or childbirth.

Uses

Fibrostat is used to reduce bleeding after trauma, surgery or childbirth. It is also used to reduce excessive menstrual blood loss in women. In addition, this medication is used to treat and prevent nosebleeds, as well as to reduce the risk of bleeding in patients who are taking an anticoagulant such as warfarin.

Mechanism of Action

Tranexamic acid works by blocking enzymes that break down blood clots. This prevents clots from being degraded, which helps to reduce the risk of bleeding or further bleeding in people who are at risk.

How Long Does it Take to Work?

Tranexamic acid begins to work within a few minutes of taking the medication. However, the full effect of the medication may take up to 24 hours to be seen.

Absorption

Tranexamic acid is well absorbed after oral administration, with peak plasma concentrations occurring 1 – 2 hours after dosing.

Route of Elimination

Tranexamic acid is rapidly eliminated from the body, with 50% of a dose excreted in the urine within 24 hours.

Dosage

Tranexamic acid is available in oral tablet or injection form. The dosage of tranexamic acid is based on the medical condition and response to treatment.

For Oral Administration

The usual dose is 1 – 2 tablets (1 – 2 g) taken 3 – 4 times daily.

For Intramuscular Injection

The usual dose is 1 – 2 g intramuscularly every 8 hours.

Administration

Tranexamic acid may be taken orally or given as an injection into the muscle.

Side Effects

Common side effects of tranexamic acid include headaches, nausea, vomiting, and dizziness. Other less common side effects include stomach pain, diarrhea, constipation, and difficulty sleeping.

Toxicity

Tranexamic acid is generally well tolerated; however, it can be toxic in high doses or when taken for prolonged periods of time. If an overdose is suspected, seek medical attention immediately.

Precautions

Before taking tranexamic acid, inform your doctor if you have a history of blood clots, kidney or liver disease, or any other medical condition. Tell your doctor if you are pregnant or breastfeeding.

Drug Interactions

Tranexamic acid may interact with other medications such as warfarin, aspirin, and heparin. Tell your doctor about all the medications you are taking before starting tranexamic acid, to ensure no interactions occur.

Food Interactions

It is best to avoid consuming alcohol when taking tranexamic acid as it may increase the risk of side effects.

Pregnancy Use

There is insufficient data available to assess the safety of tranexamic acid during pregnancy. Therefore, the use of tranexamic acid during pregnancy is not recommended.

Lactation Use

It is not known whether tranexamic acid passes into breastmilk. Therefore, the use of tranexamic acid while breastfeeding is not recommended.

Acute Overdose

Signs of an acute overdose include stomach pain, nausea, vomiting and breathing difficulty. Seeking medical attention is advised if an overdose is suspected as tranexamic acid can be toxic in high doses.

Contraindication

Tranexamic acid is contraindicated in patients with a history of active thrombosis, or in patients who have a history of thromboembolic events. It is also contraindicated in patients with an active bleeding disorder, or with a history of allergic reaction to any component of tranexamic acid.

Use Directions

Tranexamic acid should be taken as directed by your doctor. Do not take more or less than the recommended dose, and do not take it for longer than prescribed. It is usually taken three or four times a day.

Storage Conditions

Store in a dry place away from direct light. Do not store above 30oC (86oF).

Volume of Distribution

The volume of distribution of tranexamic acid is approximately 16L.

Half Life

The elimination half-life of tranexamic acid is approximately 2 to 3 hours.

Clearance

The renal clearance of tranexamic acid is approximately 15 mL/min.

Here you find in details version of Fibrostat

Some Frequently Asked Questions About Fibrostat

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1. What is Fibrostat?

Tranexamic acid is a medication used to treat or prevent excessive blood loss from major trauma, surgery, and in some cases of hemorrhagic (bleeding) stroke. It is a synthetic derivative of the amino acid lysine and is commonly sold under the brand names Lysteda and Cyklokapron.

2. What are the side effects of Tranexamic acid?

Common side effects of tranexamic acid include nausea, vomiting, headache, dizziness, abdominal pain, and diarrhea. Less common, but more serious side effects, include difficulty breathing, rash, hives, and unusual bleeding.

3. How long does it take for Fibrostat to work?

Tranexamic acid typically takes about 15 minutes to start working after being taken orally. Its effects usually last for up to 8 hours.

4. How is Fibrostat taken?

Tranexamic acid is usually taken orally as a tablet or as an oral solution. It is also available as an injection.

5. Is Fibrostat safe to use?

Tranexamic acid is generally considered safe to use when taken as directed. However, it can cause some serious side effects, so it is important to speak with a doctor before taking it.

6. What are the uses of Fibrostat?

Tranexamic acid is used to treat or prevent excessive blood loss from major trauma, surgery, and in some cases of hemorrhagic (bleeding) stroke. It can also be used to treat heavy menstrual bleeding and as an antifibrinolytic agent in a variety of other conditions.

7. Who should not take Fibrostat?

Tranexamic acid should not be used by people with an active or recent history of thrombosis (blood clots), certain bleeding disorders, severe kidney or liver disease, or a history of stroke. It should also not be used by women who are pregnant or breastfeeding.

8. What is the dosage of Fibrostat?

The dosage of tranexamic acid can vary depending on the medical condition being treated. Generally, the recommended dose is 1-2g taken three or four times per day.

9. Is Fibrostat available over the counter?

Tranexamic acid is not available over the counter. It must be prescribed by a doctor.

10. How long should you take Fibrostat?

Tranexamic acid is usually taken for only a short period of time. Talk to your doctor about the length of time you should take tranexamic acid.

11. What are some alternatives to Fibrostat?

Some alternatives to tranexamic acid include antifibrinolytic agents such as aprotinin, tranexamic acid derivatives such as tranexamic acid monohydrate, and hemostatic agents such as fibrin sealant.

12. Is Fibrostat safe for long-term use?

Tranexamic acid is generally considered safe to use when taken as directed, but it is best to consult with a doctor before taking it for long periods of time.

13. Can I take Fibrostat while breastfeeding?

Tranexamic acid is not recommended for use while breastfeeding. Consult your doctor before taking any medication while breastfeeding.

14. Does Fibrostat interact with any other drugs?

Tranexamic acid may interact with certain drugs, including warfarin, furosemide, and nonsteroidal anti-inflammatory drugs. Be sure to tell your doctor about any other medications you are taking before you start taking tranexamic acid.

15. Is Fibrostat addictive?

Tranexamic acid is not considered to be addictive.

16. How should Fibrostat be stored?

Tranexamic acid should be stored at room temperature, away from moisture, heat, and light. Make sure the medication is out of reach of children and pets.

17. What happens if I miss a dose of Fibrostat?

If you miss a dose of tranexamic acid, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.

18. Should I take Fibrostat with food or on an empty stomach?

Traditionally, tranexamic acid is taken with food or on an empty stomach. However, check with your doctor or pharmacist for the best way to take the medication for your particular situation.

19. Is Fibrostat a blood thinner?

No, tranexamic acid is not a blood thinner. It is an antifibrinolytic agent, which means it helps reduce excessive bleeding by preventing the breakdown of blood clots.

20. Can I drink alcohol while taking Fibrostat?

You should not drink alcohol while taking tranexamic acid. Alcohol can increase the risk of side effects, such as nausea, vomiting, drowsiness, and dizziness.

21. Does Fibrostat have any interactions with food?

Tranexamic acid does not have any known interactions with food. However, it is best to check with your doctor or pharmacist before taking any medication.

22. How quickly does Fibrostat work?

Tranexamic acid typically works within 15 minutes of being taken orally. Its effects usually last for up to 8 hours.

23. Can Fibrostat be used for heavy menstrual bleeding?

Tranexamic acid can be used to treat heavy menstrual bleeding in women. However, it is important to speak with a doctor before taking this medication.

24. Are there any other uses for Fibrostat?

Tranexamic acid can also be used as an antifibrinolytic agent in a variety of other conditions such as thrombolysis, transplant surgery, and wound healing.

25. Is there a generic version of Fibrostat?

Yes, there is a generic version of tranexamic acid available. It is sold under the names Cyklokapron and Fibrostat.

26. Does Fibrostat have any other names?

Tranexamic acid is also known by the brand names Lysteda and Cyklokapron, as well as the generic name tranexamic acid.

27. What is the difference between Tranexamic acid and blood thinners?

The main difference between tranexamic acid and blood thinners is that tranexamic acid is an antifibrinolytic agent, which means it helps reduce excessive bleeding by preventing the breakdown of blood clots. Blood thinners, on the other hand, work by making your blood less likely to clot, thus reducing the risk of strokes and heart attacks.

28. Is there an injection form of Fibrostat?

Yes, tranexamic acid is also available as an injection. Talk to your doctor about which form of tranexamic acid is best for you.

29. Does Fibrostat cause headaches?

Headache is a common side effect of tranexamic acid. If you experience headaches while taking tranexamic acid, tell your doctor so they can adjust your dosage or stop use of the medication.

30. What laboratory tests should be done before taking Fibrostat?

Before taking tranexamic acid, your doctor may order certain laboratory tests, such as a blood count, complete blood count, clotting time, prothrombin time, and blood chemistry tests. These tests will help your doctor determine whether tranexamic acid is safe for you to take.

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