Ferrous Sulfate

Ferrous Sulfate, a brand name for a formulation containing essential Ferrous Sulfate, is widely used for various health benefits. This guide provides comprehensive information on the uses, dosage, side effects, and mechanism of action of Ferrous Sulfate, as well as insights into how long it takes to work. Understanding these aspects can help you make informed decisions about its use and effectiveness.

Ferrous Sulfate

Ferrous Sulfate is an inorganic compound used primarily to treat iron deficiency anemia. It can be taken in both an oral supplement form as well as an intravenous solution. It is a form of elemental iron, which is the main component of hemoglobin, the protein that carries oxygen in red blood cells.


Ferrous sulfate is used to treat iron deficiency anemia, a condition in which the body does not produce enough hemoglobin and red blood cells due to a lack of dietary iron. It is also used to treat conditions associated with low iron levels such as anemia, poor bone growth, and developmental delays in some children. Ferrous sulfate is also occasionally used to treat anemia caused by certain medical conditions such as chronic kidney disease.

Mechanism of Action

Ferrous sulfate works by increasing the amount of iron in the body. When iron levels are increased, the body produces more hemoglobin, which aids in the transport of oxygen in red blood cells. Additionally, hemoglobin helps the body to transport carbon dioxide out of cells. This helps to increase energy levels and can help to improve overall health.

How Long Does it Take to Work?

The length of time it takes for Ferrous Sulfate to work varies depending on the individual. Typically, it takes several weeks to several months for the body to fully absorb the iron and see an improvement in symptoms. It is important to speak with a physician for individualized information regarding the timeline.

Absorption and Route of Elimination

Ferrous Sulfate is absorbed into the body through the gastrointestinal tract. Once it is absorbed into the bloodstream, it is transformed into ferric iron, which binds to the transferrin molecule in the plasma and is circulated throughout the body. Ferrous Sulfate is eliminated through the kidneys primarily in urine and feces.


Ferrous Sulfate is available in different formulations including capsules, tablets, syrup, drops, and IV solutions. Typical adult doses range from 65-200mg daily. The optimal dosage and duration of treatment depends on the individual and their specific needs. It is important to speak with a healthcare provider before starting or changing any dosage.


Ferrous sulfate can be taken orally, via syrup or tablets, or via intravenous (IV) solution. Additionally, some products are designed to be mixed with liquid or food before consumption. People should always follow the directions given by their healthcare provider when taking this medication.

Side Effects

Common side effects of Ferrous Sulfate include: nausea, abdominal pain, constipation, vomiting, diarrhoea, darkening of urine and stools, dizziness, headaches, and fatigue. If any of these side effects persist or worsen, it is important to contact a healthcare provider immediately.


The toxic dose of Ferrous Sulfate varies among individuals, but ingestion of more than 200mg per kilogram of body weight can be dangerous. Symptoms of toxicity may include extreme drowsiness, vomiting, stomach pain, and diarrhea. If any of these symptoms occur, healthcare should be sought immediately.


Ferrous Sulfate should not be used by individuals who have iron overload due to conditions like hemochromatosis. It should also be avoided by those with kidney problems, stomach or intestinal ulcers, certain heart conditions, and liver disease. People should also consult a healthcare provider before using this medication if they are pregnant, breastfeeding, or trying to become pregnant.


Ferrous Sulfate can interact with penicillamine, tetracycline, warfarin, vitamin E, and calcium supplements. It can also interact with certain antacids such as sucralfate and citrate supplements. People should always check with a healthcare provider before taking any medications, herbs, and supplements to make sure they are safe for use with Ferrous Sulfate.

Disease Interactions

Ferrous Sulfate can interact with conditions such as anemia due to certain medical conditions, hemochromatosis, ulcerative colitis, and Crohn's Disease. It should also be avoided by individuals with a history of kidney disease, heart problems, liver disease, and stomach or intestinal ulcers. People should speak with a healthcare provider before taking this drug if they have any of these conditions.

Drug-Drug Interactions

Ferrous Sulfate can interact with medications such as penicillamine, antacids, and tetracycline. It can also interact with herbs and supplements such as vitamin E and calcium. People should always consult their healthcare provider before taking this medication with any other medications, herbs, or supplements.

Food Interactions

Ferrous Sulfate can interact with certain foods and beverages such as dairy products, caffeine, and alcohol. Consuming large amounts of carbohydrate-rich foods like bread, pasta, and rice can also decrease the absorption of the medication. People should discuss their diet with their healthcare provider before taking Ferrous Sulfate.

Pregnancy Use

Ferrous Sulfate is an FDA Pregnancy Category C drug, which means it is not known if the drug is harmful to unborn babies. Women should always consult their doctor before taking Ferrous Sulfate during pregnancy.

Lactation Use

It is not known if Ferrous Sulfate passes into breast milk. Women should always check with their doctor before taking this medication if they are breastfeeding.

Acute Overdose

If a person has accidentally taken an excessive amount of Ferrous Sulfate, they may experience symptoms such as dizziness, nausea, vomiting, stomach pain, diarrhea, and darkening of the urine. If any of these symptoms occur, they should seek medical attention right away.


Ferrous Sulfate is not indicated in people with iron overload, such as those with hemochromatosis, or with severe kidney phosphite, or liver disease. It should also be avoided by people with histories of stomach or intestinal ulcers, and people who have experienced cardiac events caused by taking the drug.

Use Direction

It is important to take Ferrous Sulfate exactly as it has been prescribed. The patient should follow their healthcare provider's instructions regarding dosage and timing. The patient should not take more than the recommended dosage or take it longer than the prescribed period of time.

Storage Conditions

Ferrous Sulfate should be stored at room temperature in a secure location away from children. It is important to discard any expired medications in an appropriate manner.

Volume of Distribution

The volume of distribution for Ferrous Sulfate is approximately 2.2L/kg. This means that, on average, the drug distributes two liters of the medication per kilogram of body weight.

Half Life

The half-life of Ferrous Sulfate is approximately 8-9 hours. This means that, on average, half of the medication will be eliminated from the body within 8-9 hours.


The clearance of Ferrous Sulfate is approximately 8.7-13.7 ml/min. This means that, on average, approximately 9-14 milliliters of the medication will be eliminated from the body per minute.

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