Fenofibratum, a brand name for a formulation containing essential Fenofibrate, is widely used for various health benefits. This guide provides comprehensive information on the uses, dosage, side effects, and mechanism of action of Fenofibratum, as well as insights into how long it takes to work. Understanding these aspects can help you make informed decisions about its use and effectiveness.

Fenofibratum Introduction & Uses For

Fenofibratum is a drug used to reduce cholesterol levels. It belongs to a class of drugs known as fibrates and works to lower unhealthy levels of cholesterol and triglycerides in the blood. Fenofibratum is commonly prescribed to treat high cholesterol and can be used alone or in combination with other cholesterol-lowering medicines. It may also be used to help reduce the risk of heart attack and stroke in people with certain types of heart disease.

Mechanism of Action

Fenofibratum works to reduce cholesterol levels by blocking the action of an enzyme known as HMG-CoA reductase. This enzyme is responsible for the production of cholesterol in the body, so blocking its action helps to reduce the production of cholesterol. Fenofibratum also works by increasing the production of bile acids, which promotes the breakdown and excretion of cholesterol in the body. The drug also increases the activity of lipoprotein lipase, an enzyme that helps to break down and eliminate triglycerides in the blood.

How Long Does It Take to Work?

The effects of fenofibrate may take up to 4 weeks to become fully effective. It is important to continue taking the medication as prescribed, even if it does not seem to be working right away. Your cholesterol levels may start to drop after 1 or 2 weeks, but it may take longer for the drug to reach its full effectiveness.

Absorption, Route of Elimination, & Dosage

Fenofibratum is absorbed through the gastrointestinal tract and then eliminated primarily through the kidney. The recommended dose is usually 1 tablet (133 mg) once daily, but it may be increased to a maximum dose of 3 tablets (400 mg) daily. Your doctor will adjust your dose as needed to control your cholesterol levels.

Administration & Side Effects

Fenofibratum should be taken orally, usually once a day with food or as directed by your doctor. The most common side effects of fenofibrate are digestive problems such as nausea, gas, and diarrhea. Other side effects may include headache, muscle pain, dizziness, and rash.

Toxicity, Precaution & Interaction

Fenofibratum is generally well tolerated but may be toxic if taken in large doses. It is important to follow your doctor's instructions when taking this medication. Fenofibratum may interact with certain other medications, so tell your doctor about any other drugs you are taking.

Disease Interaction, Drug Interaction, Food Interactions, Pregnancy Use, & Lactation Use

Fenofibratum may interact with certain diseases, drugs, foods, and other substances. It is important to tell your doctor if you have any of these conditions before taking fenofibrate. Since fenofibrate may not be safe for use during pregnancy, it is important that pregnant women do not take this medication. Fenofibratum is believed to be safe for use during lactation.

Acute Overdose, Contraindication, Use Direction, & Storage Condition

Fenofibratum is only for use as prescribed by a doctor and should never be taken in an overdose. Taking too much fenofibrate can lead to serious side effects and toxicity. Fenofibratum should not be used in people with certain conditions or allergies. It is important to follow the directions provided by your doctor when using this medication. Store fenofibrate at room temperature and away from heat and moisture.

Volume of Distribution, Half Life, & Clearance

The volume of distribution of fenofibrate is approximately 13 L/kg. The drug has a half-life of 3 hours and is cleared by the kidneys.

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