ফেভির‍্যাব এ আছে Rabies Immune Globulin। ফেভির‍্যাব এর কাজঃ

For the seroprophylaxis (prevention by injecting antibodies) of rabies in subjects suspected to have been exposed to the rabies virus, particularly in the event of severe exposure e.g.:

  • Multiple transdermal bites or scratches
  • Contamination of mucous membrane with saliva
  • Severe bites located on the face, head, neck and hands
  • When the domestic or wild animal responsible cannot be examined or is infected or suspected to be infected by the rabies virus
  • Bites to young children

Rabies immunoglobulin provides passive immunization against rabies for prevention of rabies in patients after contact with a rabid animal or an animal presumed to be rabid. Anti rabies serum itself does not constitute an anti rabies treatment and should always be used in conjunction with rabies vaccine.

Rabies immunoglobulin is a sterile, non-pyrogenic solution for intra-muscular administration, containing antiviral substances obtained from the blood serum of healthy equines that have been immunized against rabies by vaccination. In addition, it also contains the anti-microbial agent cresol.

 

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ব্র্যান্ড নাম ফেভির‍্যাব
জেনেরিকঃ Rabies Immune Globulin
পরিমাপঃ 1000 IU/5 ml
ধরণঃ আইএম ইনজেকশন
চিকিৎসাগত শ্রেণিঃ Vaccines, Anti-sera & Immunoglobulin
উৎপাদনকারীঃ Sanofi Pasteur
দামঃ 1.40
সর্বশেষ সম্পাদনাঃ 2020-11-21 18:15:00
পরিচিতি

Rabies immunoglobulins provide passive immunity to rabies. 2 types of immunoglobulin are available namely, human rabies immunoglobulin (HRIG) and purified equine rabies immunoglobulin (ERIG). HRIG is prepared from the plasma of human donors hyperimmunised with rabies vaccine and is preferred over ERIG.

খাওয়ার নিয়ম

ফেভির‍্যাব এ আছে Rabies Immune Globulin 1000 IU/5 ml। ফেভির‍্যাব খাওয়ার নিয়ম নিম্নরূপঃ

First-aid treatment: Prompt local treatment of bite wounds and scratches that may be contaminated with rabies virus is important, whatever the time elapsed since the contact. The recommended first-aid measures consist of immediate flushing and washing of the wound with soap and water, detergent or other substance of proven lethal effect on rabies virus. The Rabies Immunoglobulin should be injected as soon as possible after exposure.

The recommended dose for both adults and children is 40 lU/kg of body weight. If anatomically feasible, as much as possible of the dose should be infiltrated around and into the wound(s). The remainder should be administered intramuscularly (into the gluteal region) in a single injection.

However, for children, particularly in the case of multiple wounds, it has been proposed to dilute the dose 2-3 times in a 0.9% sodium chloride solution to obtain a sufficient quantity of equine Rabies Immunoglobulin to infiltrate the wound(s) correctly. Wounds in certain anatomical sites (fingertips) should be infiltrated with care so as to prevent a local increase in pressure in the tissue.

For prevention of rabies, combined immunoglobulin-vaccine treatment is recommended. The 1st dose of the rabies vaccine should be given at the same time as the Rabies Immunoglobulin, but in different parts of the body. If Rabies Immunoglobulin is not available when the rabies vaccine is administered, it can be administered up to the 7th or 8th day after the first dose of rabies vaccine. When indicated, begin anti-tetanus treatment and administer anti-microbial drugs to control infections other than rabies.

The WHO expert committee on rabies has issued the following therapeutic recommendations:

Touching or feeding of animal, licks on intact skin: 

  • Recommended treatment: None, if reliable case history is available.

Nibbling of uncovered skin, minor scratches superficial bites (except on head, neck, shoulder girdle,arms or hands) or abrasions without bleeding, licks on broken skin. 

  • Recommended treatment: Administer vaccine immediately on Day 0, D3, D7, D14 and D28.Stop treatment if animal remains healthy throughout the observation period of 10 days or if animal is killed humanely and found to be negative by appropriate laboratory techniques.

Single or multiple transdermal bites or scratches specially on head, neck, shoulder girdle,arms or hands. Contamination of mucus membrane with saliva (i.e. licks on broken skin). 

  • Recommended treatment: Administer rabies vaccine immediately on Day 0, D3, D7, D14 and D28 or D90 (optional) and Rabies Immunoglobulin on DO immediately. Stop treatment if animal remains healthy throughout the observation period of 10 days or if animal is killed humanely and found to be negative by appropriate laboratory techniques..

 

পার্শ্বপ্রতিক্রিয়া

Immediate or delayed hypersensitive type reactions may be developed on administration of rabies immunoglobulin. The observed immediate reactions are hypotension, dyspnoea, and urticaria. Delayed reactions consist of inflammatory reaction, fever, pruritis, rash or urticaria, adenopathy and arthralgia.

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সতর্কতা

Do not administer rabies immunoglobulin intravenously (due to the risk of shock i.e., sudden collapse with drop in blood pressure). Consequently, make sure that the needle has not penetrated a blood vessel. Rabies immunoglobulin should not be administered in repeated doses. Once the vaccine treatment has been started, repeating injections of rabies immunoglobulin may reduce the protective efficacy that must be guaranteed by the vaccine. Shake well before use. Do not shake vigorously.

প্রতিক্রিয়া

For treatment associating rabies immunoglobulin and rabies vaccine, the rabies vaccine should be injected in a contra lateral anatomic site (i.e., on opposite side) using a different syringe. As a general rule, corticosteroids, liable to attenuate the immune response, should be avoided.

গর্ভকালীন কিংবা দুগ্ধদানকালীন অবস্থায় ব্যবহার

The safety of rabies immunoglobulin when used during pregnancy has not been established in clinical trials in human beings. Considering the lethal risk associated with rabies, pregnancy may not be a contraindication to the administration of rabies immunoglobulin subsequent to exposure.

প্রতিনির্দেশনা

Known history of allergic symptoms to horse proteins. Nevertheless, the lethal risk associated with rabies overcomes any potential contraindication.

বিশেষ সতর্কতা

 

মাত্রাতিরিক্ত সেবনের প্রতিক্রিয়া

If the recommended dosage is not strictly observed, there is a risk of immunosuppressive interference (suppression of immune defenses) with rabies vaccine.

অন্যান্য ঔষধের সাথে প্রতিক্রিয়া

 

সংরক্ষণ

Keep out of the reach and sight of children. Store at +2°C to +8°C. Transportation should also be at +2°C to +8°C. Protect from light. Do not freeze Commercial pack

ফেভির‍্যাব আইএম ইনজেকশন এর দাম 1.40

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