এক্সটালস এ আছে Riluzole। এক্সটালস এর কাজঃ
এক্সটালস is indicated for the treatment of amyotrophic lateral sclerosis (ALS).
|Extals Tablet 50 mg in bangla|
|চিকিৎসাগত শ্রেণিঃ||Neurodegenerative Disease Drugs / Neuromuscular Disorder Drugs|
|উৎপাদনকারীঃ||Unimed Unihealth MFG. Ltd|
|সর্বশেষ সম্পাদনাঃ||2020-11-20 18:15:00|
The mode of action of riluzole is unknown. Its pharmacological properties include the following, some of which may be related to its effect:
এক্সটালস এ আছে Riluzole 50 mg। এক্সটালস খাওয়ার নিয়ম নিম্নরূপঃ
The recommended dosage for এক্সটালস is 50 mg taken orally twice daily. এক্সটালস should be taken at least 1 hour before or 2 hours after a meal. Measure serum aminotransferases before and during treatment with এক্সটালস
The following adverse reactions are described below and elsewhere in the labeling: Hepatic Injury, Neutropenia, Interstitial lung disease
Hepatic Injury: Cases of drug-induced liver injury, some of which were fatal, have been reported in patients taking এক্সটালস. Asymptomatic elevations of hepatic transaminases have also been reported, and in some patients have recurred upon rechallenge with এক্সটালস.
In clinical studies, the incidence of elevations in hepatic transaminases was greater in এক্সটালসtreated patients than placebo-treated patients. The incidence of elevations of ALT above 5 times the upper limit of normal (ULN) was 2% in এক্সটালস-treated patients. Maximum increases in ALT occurred within 3 months after starting এক্সটালস. About 50% and 8% of এক্সটালসtreated patients in pooled Studies 1 and 2, had at least one elevated ALT level above ULN and above 3 times ULN, respectively
Monitor patients for signs and symptoms of hepatic injury, every month for the first 3 months of treatment, and periodically thereafter. The use of এক্সটালস is not recommended if patients develop hepatic transaminases levels greater than 5 times the ULN. Discontinue এক্সটালস if there is evidence of liver dysfunction (e.g., elevated bilirubin).
Neutropenia: Cases of severe neutropenia (absolute neutrophil count less than 500 per mm3) within the first 2 months of এক্সটালস treatment have been reported. Advise patients to report febrile illnesses.
Interstitial Lung Disease: Interstitial lung disease, including hypersensitivity pneumonitis, has occurred in patients taking এক্সটালস. Discontinue এক্সটালস immediately if interstitial lung disease develops.
Strong to moderate CYP1A2 inhibitors: Coadministration may increase এক্সটালস-associated adverse reactions
Strong to moderate CYP1A2 inducers: Coadministration may result in decreased efficacy
Hepatotoxic drugs: এক্সটালস-treated patients that take other hepatotoxic drugs may be at increased risk for hepatotoxicity
Pregnancy: Based on animal data, may cause fetal harm
Lactation: It is not known if riluzole is excreted in human milk. এক্সটালস or its metabolites have been detected in milk of lactating rat. Women should be advised that many drugs are excreted in human milk and that the potential for serious adverse reactions in nursing infants from এক্সটালস is unknown.
এক্সটালস is contraindicated in patients with a history of severe hypersensitivity reactions to riluzole or to any of its components (anaphylaxis has occurred)
Reported symptoms of overdose following ingestion of এক্সটালস ranging from 1.5 to 3 grams (30 to 60 times the recommended dose) included acute toxic encephalopathy, coma, drowsiness, memory loss, and methemoglobinemia. No specific antidote for the treatment of এক্সটালস overdose is available.
Store at controlled room temperature, 20°C to 25°C, and protect from bright light.
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