Expile

Expile Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Expile is a brand name. Its generic name is Micronised Diosmin + Hesperidin.

Expile

Expile is a combination of bioflavonoids derived from the citrus fruit and plant that have been used traditionally for decades. These two natural compounds, Diosmin and Hesperidin, are often used together due to their synergistic effects – research has shown that they are more effective when combined than when taken individually.

Uses

The most common uses of Diosmin and Hesperidin are for the treatment of conditions related to poor circulation and venous insufficiency. It is used for leg swelling, varicose veins, hemorrhoids, and chronic venous insufficiency. It is also used for other conditions, including lymphedema, chronic venous ulcers, and chronic venous hypertension.

Mechanism of Action

The exact mechanism of action is not fully understood, but it is believed to improve circulation by increasing capillary permeability, reducing venous and lymphatic stasis, and improving venous tone and vascular elasticity. It may also possess anti-inflammatory and antioxidant properties.

How Long Does it Take to Work?

The effects of Expile can be seen as soon as two weeks after starting treatment, but it may take up to 12 weeks to see significant results. It is important to take this medication for the prescribed length of time before judging its effectiveness.

Absorption

Diosmin and Hesperidin are absorbed from the gastrointestinal tract. In one study, micronized Diosmin + Hesperidin was found to have greater bioavailability than a non-micronized form of the same medication.

Route of Elimination

Diosmin and Hesperidin are metabolized by the liver and then excreted in the urine.

Dosage

The usual adult dosage of Expile is 500 mg per day, taken in two or three divided doses. It is recommended to take this medication with meals, as the presence of food can improve the absorption of Diosmin and Hesperidin.

Administration

Expile should ideally be taken on a full stomach to maximize absorption. If taking in divided doses, take each dose with a meal. This medication should be swallowed whole, not chewed or crushed.

Side Effect

Common side effects of Expile include nausea, abdominal pain, diarrhea, and headache. Rare side effects may include allergic reactions and rash. Discontinue use and consult a medical professional if any severe reactions or symptoms occur.

Toxicity

Diosmin and Hesperidin have not been found to be toxic even at high doses.

Precaution

This medication may interact with other medications, and people should make sure to discuss their full medical history with their doctor before taking Expile. Additionally, it is recommended to avoid alcohol while taking this medication since it can increase the side effects.

Interaction

It is possible that Expile may interact with other medications, so patients should consult their doctor before taking any new medications. Additionally, it is recommended to avoid alcohol while taking this medication since it can increase the side effects.

Disease Interactions

There are no known disease interactions with Expile.

Drug Interactions

Drugs that may interact with Expile include antiplatelet drugs, anticoagulants, and statins. It is also possible that this medication may interact with prescription medications and herbal supplements. Patients should always consult their doctor before taking any new medications or supplements.

Food Interactions

Food interactions are not known with Expile. However, it is still recommended to take this medication with food since the presence of food may improve the absorption.

Pregnancy Use

Expile should not be taken during pregnancy as the safety of this medication has not been studied in pregnant women. Therefore, pregnant women should avoid taking this medication.

Lactation Use

This medication should not be taken while breast-feeding as the safety of this medication has not been studied in breastfeeding mothers. Therefore, nursing mothers should discontinue use and consult their doctor before taking this medication.

Acute Overdose

In the case of an acute overdose of Expile, seek medical attention immediately. Symptoms of an overdose may include nausea, vomiting, diarrhea, and abdominal pain.

Contraindication

This medication is contraindicated in patients with known hypersensitivity to any of its components.

Use Direction

Expile should be taken as directed by the doctor. The usual dose is 500 mg per day, taken in two or three divided doses with food. Make sure to take this medication for the prescribed length of time before judging its effectiveness.

Storage Condition

This medication should be stored at room temperature in a tightly sealed container away from moisture and heat.

Volume of Distribution

The volume of distribution of Expile is unknown.

Half Life

The half life of Diosmin and Hesperidin is approximately 7 hours.

Clearance

The clearance rate of Diosmin and Hesperidin is unknown.

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