Evarin

Evarin Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Evarin is a brand name. Its generic name is Mebeverine.

Evarin Introduction

Evarin is an antispasmodic drug which is used to relax the muscles in the digestive system. Evarin hydrochloride is the hydrochloride salt of an ethylenediamine derivative, mebeverine. It is used in the symptomatic treatment of gastrointestinal spasm associated with irritable bowel syndrome. It helps to reduce symptoms such as stomach cramps, abdominal pain, and irregular and painful bowel movements.

Uses For

Evarin is used to treat cramps or spasms of the stomach and intestines. It is also used to treat irritable bowel syndrome.

Mechanism of Action

Evarin works to relax the muscles at the level of the stomach and intestine walls to help reduce abdominal pain, cramps, and irritable bowel syndrome (IBS). It acts on muscarinic receptors (cholinergic receptors) within the intestines, slowing the rate of muscle contraction. This slows the passage of food through the digestive system, increasing the absorption of water through the bowels and ultimately alleviating cramps, pain, and other IBS symptoms.

How Long Does It Take To Work?

Evarin usually starts to work within 1-2 hours of taking the tablet, although in some cases it may take up to 3 days to feel the full effect.

Absorption

Evarin is rapidly and almost completely absorbed after oral administration. Peak plasma concentrations are achieved 1 to 2 hours after administration. Evarin has a bioavailability of approximately 90%; it is not significantly influenced by food.

Route of Elimination

Evarin is eliminated by hepatic metabolism to inactive metabolites. The metabolites are excreted mainly in the urine.

Dosage

Evarin is available as tablets or as capsules that can be taken orally. Usual adult dosage is 135 mg three times per day between meals, and the usual dosage for children is 20-45 mg three times per day between meals.

Administration

Evarin should be taken with a glass of water before meals, with meals or after meals. It can be taken with or without food. It is important to take mebeverine on a regular basis and at the same time each day as this will help the patient to remember to take it and increase the chances of receiving the maximum benefit.

Side Effect

Common side effects of mebeverine include headache, nausea, abdominal pain, and dizziness. Rare side effects include severe allergic reactions (anaphylactic reaction), Stevens-Johnson syndrome, increased tear production, blurred vision, chest pain, and difficulty breathing.

Toxicity

Evarin is generally well tolerated and has a low toxicity profile. In animal studies, the LD50 is shown to be greater than 12g/kg body weight.

Precaution

Patients should inform their doctor of any other medications they take, as well as any history of asthma, eczema or an allergy, or any other allergies (e.g. food allergies). Evarin should be used cautiously in patients with a history of seizures, kidney or liver disease, or a certain type of intestinal obstruction.

Interaction

Evarin may interact with certain medications like antacids, digoxin, warfarin, and metoclopramide. Patients should inform their doctor of all medications taken prior to taking mebeverine as these could interact and increase the risk of side effects occurring.

Disease Interaction

Evarin is not suitable for use by patients with a tachycardia, hypersensitivity to mebeverine, or bladder/intestinal obstruction.

Drug Interaction

Evarin may interact with certain medications such as antacids, digoxin, warfarin, and metoclopramide, increasing the risk of side effects.

Food Interactions

Evarin is not known to interact with food. However, it may interact with foods high in tyramine such as aged cheese, yogurt, smoked fish, and certain beers or wines.

Pregnancy Use

Evarin is not recommended for use during pregnancy. It is not known if mebeverine can pass into breast milk, but it is unlikely to cause harm to a nursing infant.

Lactation Use

Evarin is not recommended for use while breastfeeding as it is not known if mebeverine can pass into breast milk and cause harm to an infant.

Acute Overdose

In case of an acute overdose of mebeverine, doctors may recommend gastric lavage, activated charcoal and supportive measures in order to absorb and eliminate the drug.

Contraindication

Evarin is contraindicated in patients with a known sensitivity or allergy to mebeverine, other lincomycin antibiotics, or any of the other ingredients in the product.

Use Direction

Evarin tablets should be taken orally, with a glass of water before, with, or after meals. Do not take more than the prescribed dose or exceed the recommended frequency.

Storage Condition

Evarin should be stored at room temperature in a dry, dark place away from heat and direct sunlight. Keep it in a tightly sealed container, away from children and pets.

Volume of Distribution

The volume of distribution of mebeverine is 4.8 L/kg.

Half Life

The elimination half-life of mebeverine is 7 hours.

Clearance

The clearance of mebeverine is 116 ml/min/1.73 m2.

Here you find in details version of Evarin

Some Frequently Asked Questions About Evarin

What is Evarin?

Evarin is a medication used to treat irritable bowel syndrome (IBS), and inflammatory bowel disease (such as ulcerative colitis and Crohn's disease). It works by slowing down the movement of the muscles in the intestine, which helps reduce pain and cramping.

How does Evarin work?

Evarin works by decreasing the contractile activity of the muscles in the intestine which helps reduce pain and cramping that is associated with irritable bowel syndrome (IBS) and certain inflammatory bowel diseases (ulcerative colitis and Crohn's disease).

What are the side effects of Evarin?

The most common side effects associated with taking mebeverine include nausea, vomiting, constipation, and headache. Other possible side effects include dry mouth, insomnia, nervousness, dizziness, diarrhoea, and skin rash.

Do I need a prescription for Evarin?

Yes, Evarin is a prescription medication and must be obtained from your doctor or healthcare provider.

How should Evarin be taken?

Evarin should be taken exactly as prescribed by your doctor or healthcare provider. Do not change your dose or stop taking Evarin without first consulting with your healthcare provider.

Is Evarin safe?

Yes, Evarin is generally considered safe when taken as prescribed by a medical professional. However, there may be certain side effects associated with taking Evarin. Check with your doctor or healthcare provider for more information.

Can I take Evarin with other medications?

It is important to tell your doctor or healthcare provider if you are taking any other medications, including over-the-counter medications, herbal remedies or supplements. Do not take any new medication without first consulting your doctor or healthcare provider.

How long does it take for Evarin to work?

The effects of Evarin can be felt within several days of beginning treatment. However, it may take a few weeks before the full benefits of Evarin are experienced.

Is Evarin a narcotic?

No, Evarin is not a narcotic and does not have any mind-altering or psychoactive properties.

Can Evarin be used for other purposes?

Evarin is only approved for the treatment of irritable bowel syndrome (IBS) and certain inflammatory bowel diseases (ulcerative colitis and Crohn's disease). Do not take Evarin for any other purpose than what is prescribed by your doctor or healthcare provider.

Can Evarin be taken with food?

It is recommended to take Evarin with food or shortly after eating. Taking Evarin with food will help reduce the risk of stomach upset and other side effects.

Can I drink alcohol while taking Evarin?

It is not recommended to consume alcohol while taking Evarin. Consuming alcohol may increase the risk of side effects or decrease the effectiveness of the medication.

Is Evarin habit forming?

No, Evarin is not habit-forming and does not produce any type of physical or psychological dependence.

What should I do if I miss a dose?

If you miss a dose of Evarin, take it as soon as possible. If it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double your dose to make up for the missed dose.

What should I do if I overdose on Evarin?

If you think you have overdosed on Evarin, seek immediate medical attention. Overdosing on Evarin can cause serious side effects and should be treated as soon as possible.

What are the possible interactions with Evarin?

It is important to tell your doctor or healthcare provider about any medications, supplements, or herbal remedies you are taking before starting treatment with Evarin. Certain medications, supplements, or herbal remedies may interact with the medication and increase the risk of side effects.

Can Evarin be used during pregnancy?

There is limited data available on the use of Evarin during pregnancy and it should be used only when clearly needed. Pregnant women should consult with their doctor or healthcare provider to determine the risks and benefits of taking Evarin during pregnancy.

Can Evarin be used while breast-feeding?

There is no data available on the use of Evarin while breast-feeding and it should be used only when clearly needed. Women who are breast-feeding should consult with their doctor or healthcare provider to determine the risks and benefits of taking Evarin while breast-feeding.

Should I take Evarin every day?

Evarin should be taken as prescribed by your doctor or healthcare provider. Generally it is taken 3 times per day, preferably with meals. Do not take more or less than the recommended dose, and do not stop taking the medication without consulting your doctor or healthcare provider.

Can I stop taking Evarin without consulting my doctor?

No, it is not recommended to stop taking Evarin without first consulting with your doctor or healthcare provider. Abruptly stopping Evarin may worsen your symptoms and lead to other complications.

When will I notice improvement in my symptoms?

The effects of Evarin may be felt within several days of beginning treatment. However, it may take a few weeks before the full benefits of Evarin are experienced.

Is Evarin safe for long-term use?

Evarin is generally considered safe for long-term use, when taken as prescribed by a medical professional. However, it is important to tell your doctor if you experience any side effects or if your symptoms worsen while taking Evarin.

Can Evarin be used in children?

Evarin is not recommended for use in children under 12 years of age. Children who are 12 years and older should take Evarin only as directed by their doctor or healthcare provider.

Can I take Evarin with other medications?

It is important to tell your doctor or healthcare provider if you are taking any other medications, including over-the-counter medications, herbal remedies or supplements. Do not take any new medication without first consulting your doctor or healthcare provider.

Are there any allergies associated with Evarin?

It is not known if people who are allergic to Evarin will have an allergic reaction to other medications. Check with your doctor or healthcare provider about any allergies you may have, or if you are taking any medications for any allergies.

What flavours of Evarin are available?

Evarin is available in tablets, capsules, and syrup form. The tablets and capsules are available in various flavours, including berry, lemon, orange and vanilla.

Are there any other conditions that I should tell my doctor about before taking Evarin?

Yes, it is important to tell your doctor about any other medical conditions you may have, as these may affect the way Evarin works. Make sure to tell your doctor about allergies, any other medications you are taking, or any other medical conditions you may have.

Should I take Evarin if I have a history of liver disease?

It is not recommended to take Evarin if you have a history of liver disease, as it may cause serious side effects. Your doctor may be able to prescribe an alternative medication that is more suitable for you.

What should I do if I experience any unusual symptoms while taking Evarin?

If you experience any unusual symptoms while taking Evarin, such as dizziness, nausea, fatigue and difficulty breathing, contact your doctor or healthcare provider immediately. Do not stop taking Evarin without first consulting with your doctor or healthcare provider.

Can I take Evarin with antacids?

It is not recommended to take Evarin with antacids, as antacids may decrease the effectiveness of the medication. Talk to your doctor or healthcare provider about suitable alternatives.

Can I take Evarin with other IBS medications?

It is important to tell your doctor or healthcare provider about all medications you are taking, including any IBS medications, before starting treatment with Evarin. Certain medications may interact with Evarin and increase the risk of side effects.

What should I do if I experience any stomach pain while taking Evarin?

If you experience any stomach pain while taking Evarin, it is important to contact your doctor or healthcare provider immediately. Do not stop taking Evarin without first consulting with your doctor or healthcare provider.

Can I take Evarin with antidepressants?

It is important to tell your doctor or healthcare provider about all medications you are taking before starting treatment with Evarin. Certain medications, including antidepressants, may interact with Evarin and increase the risk of side effects.

Can Evarin be used to treat other conditions than irritable bowel syndrome (IBS) and inflammatory bowel diseases (ulcerative colitis and Crohn's disease)?

No, Evarin is only approved for the treatment of irritable bowel syndrome (IBS) and certain inflammatory bowel diseases (ulcerative colitis and Crohn's disease). Do not take Evarin for any other purpose than what is prescribed by your doctor or healthcare provider.

Is Evarin available over-the-counter?

No, Evarin is a prescription medication and must be obtained from your doctor or healthcare provider.

Can I take Evarin if I have a history of kidney disease?

Evarin is not recommended for people with a history of kidney disease, as it may cause serious side effects. Your doctor may be able to prescribe an alternative medication that is more suitable for you.

Are there any age restrictions for taking Evarin?

Evarin is not recommended for children under 12 years of age. Children who are 12 years and older should take Evarin only as directed by their doctor or healthcare provider.

How should I store Evarin?

Evarin should be stored at room temperature, away from direct sunlight, moisture, and heat. Keep out of the reach of children and pets.