ইলিডেল এ আছে Pimecrolimus। ইলিডেল এর কাজঃ

ইলিডেল Cream is indicated as second-line therapy for the short-term and non-continuous chronic treatment of mild to moderate atopic dermatitis in non-immunocompromised adults and children 2 years of age and older, who have failed to respond adequately to other topical prescription treatments, or when those treatments are not advisable.

ইলিডেল Cream is not indicated for use in children less than 2 years of age

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ব্র্যান্ড নাম ইলিডেল
জেনেরিকঃ Pimecrolimus
পরিমাপঃ 1%
ধরণঃ ক্রিম
চিকিৎসাগত শ্রেণিঃ Drugs affecting the immune response
উৎপাদনকারীঃ Novartis (Bangladesh) Ltd
দামঃ 1.40
সর্বশেষ সম্পাদনাঃ 2020-11-20 18:15:00
পরিচিতি

ইলিডেল is a macrolactam and is a derivative of ascomycin. It is an immunosuppressant which inhibits the activation of T-cells and prevents the release of inflammatory mediators from mast cells. It is used for the short term or intermittent long term treatment for mild to moderate atopic eczema.

The mechanism of action of pimecrolimus in atopic dermatitis is not known. While the following have been observed, the clinical significance of these observations in atopic dermatitis is not known. It has been demonstrated that pimecrolimus binds with high affinity to macrophilin-12 (FKBP-12) and inhibits the calcium-dependent phosphatase, calcineurin. As a consequence, it inhibits T cell activation by blocking the transcription of early cytokines. In particular, pimecrolimus inhibits at nanomolar concentrations Interleukin-2 and interferon gamma (Th1-type) and Interleukin-4 and Interleukin-10 (Th2-type) cytokine synthesis in human T-cells. In addition, pimecrolimus prevents the release of inflammatory cytokines and mediators from mast cells in vitro after stimulation by antigen/IgE.

খাওয়ার নিয়ম

ইলিডেল এ আছে Pimecrolimus 1%। ইলিডেল খাওয়ার নিয়ম নিম্নরূপঃ

Apply a thin layer of ইলিডেল Cream, 1% to the affected skin twice daily. The patient should stop using ইলিডেল Cream, 1% when signs and symptoms (e.g., itch, rash and redness) resolve and should be instructed on what actions to take if symptoms recur.

If signs and symptoms persist beyond 6 weeks, patients should be re-examined by their health care provider to confirm the diagnosis of atopic dermatitis.

Continuous long-term use of ইলিডেল Cream, 1% should be avoided, and application should be limited to areas of involvement with atopic dermatitis

The safety of ইলিডেল Cream, 1% under occlusion, which may promote systemic exposure, has not been evaluated. Avoid use of ইলিডেল Cream, 1% with occlusive dressings.

 

পার্শ্বপ্রতিক্রিয়া

Common side effects include headache, common cold or stuffy nose, sore throat, cough flu (influenza), fever, viral infection. Some people may get viral skin infections (like cold sores, chicken pox, shingles, or warts) or swollen lymph nodes (glands).

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সতর্কতা

Avoid use in areas affected by active, cutaneous viral infections. Avoid contact with the eyes and mucous membranes. Immunosuppression may increase risk of lymphoma and other malignancies. Limit exposure to sunlight or other UV light. Mild to moderate sensation of warmth and/or burning may occur at the treatment site within 1-5 days of initiation. Safety of usage beyond 1 yr is not established. Renal or hepatic impairment. Monitor renal, hepatic, cardiac and visual functions, BP, serum glucose and electrolytes regularly. Pregnancy, lactation.

প্রতিক্রিয়া

Potential interactions between ইলিডেল Cream, 1% and other drugs, including immunizations, have not been systematically evaluated. Due to low blood levels of pimecrolimus detected in some patients after topical application, systemic drug interactions are not expected, but cannot be ruled out. The concomitant administration of known CYP3A family of inhibitors in patients with widespread and/or erythrodermic disease should be done with caution. Some examples of such drugs are erythromycin, itraconazole, ketoconazole, fluconazole, calcium channel blockers and cimetidine.

গর্ভকালীন কিংবা দুগ্ধদানকালীন অবস্থায় ব্যবহার

Pregnancy Category C. There are no adequate and well-controlled studies with ইলিডেল Cream, 1% in pregnant women. Therefore, ইলিডেল Cream, 1% should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Nursing Mothers: It is not known whether this drug is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants from pimecrolimus, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

প্রতিনির্দেশনা

ইলিডেল Cream, 1% is contraindicated in individuals with a history of hypersensitivity to pimecrolimus or any of the components of the cream.

বিশেষ সতর্কতা

Renal Impairment: Dosage reduction is necessary.

Hepatic Impairment: Dosage reduction is necessary.

মাত্রাতিরিক্ত সেবনের প্রতিক্রিয়া

 

অন্যান্য ঔষধের সাথে প্রতিক্রিয়া

 

সংরক্ষণ

Store ইলিডেল Cream at room temperature between 20° to 25°C. Do not freeze

ইলিডেল ক্রিম এর দাম 1.40

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