El

El, a brand name for a formulation containing essential Enalapril, is widely used for various health benefits. This guide provides comprehensive information on the uses, dosage, side effects, and mechanism of action of El, as well as insights into how long it takes to work. Understanding these aspects can help you make informed decisions about its use and effectiveness.

El Introduction

El is an angiotensin converting enzyme (ACE) inhibitor medication used to treat high blood pressure and congestive heart failure. It works by decreasing certain chemicals that tighten the blood vessels which will then lower blood pressure and allows the heart to work efficiently.

Uses for El

El is used for treating hypertension (high blood pressure), congestive heart failure, and kidney diseases. It is also used to reduce the risk of death in patients who have had a heart attack.

Mechanism of Action

El blocks angiotensin converting enzyme (ACE). This enzyme helps the body produce a compound known as angiotensin II, which causes the blood vessels to narrow and raises blood pressure. By blocking ACE, enalapril relaxes the blood vessels, allowing for easier blood flow and lower blood pressure.

How Long Does It Take To Work?

El usually starts working within one or two hours. The full effects of the drug may take several weeks to become fully noticeable. Your doctor may increase your dose gradually over time to reach the most effective dose.

Absorption

El is rapidly and almost completely absorbed from the gastrointestinal tract. Peak plasma levels occur around 2 hours after taking a single dose.

Route of Elimination

El is eliminated from the body in the urine following metabolism in the liver. Approximately 75% of a single dose is excreted after 24 hours.

Dosage

The usual starting dose of El is 5-10 mg orally once a day. This dosage may be increased gradually over time as needed by your doctor.

  • For the treatment of hypertension: the recommended dose is 10-40 mg once a day.
  • For the treatment of congestive heart failure: the recommended dose is 5-20 mg twice daily.

Administration

El should be taken orally with or without food. It should be taken consistently either with food or without food as directed by your doctor.

Side Effects

Common side effects of enalapril include headache, nausea, diarrhea, rash, cough, and dizziness. Serious side effects may include angioedema, allergic reactions, and liver injury. If any of these side effects occur, contact your healthcare provider immediately.

Toxicity

Overdose of enalapril may result in hypotension, tachycardia, and renal failure. If an overdose is suspected, contact a poison control center as soon as possible.

Precaution

Patients should not use enalapril if they have an allergy to ACE inhibitors or have a history of angioedema. Potential side effects include low blood pressure, decreased kidney function, and liver dysfunction. Patients should also be monitored for signs of angioedema, as serious anaphylactic reactions can occur.

Interaction

El can interact with certain medications, vitamins, supplements, and minerals; therefore, it is always important to tell your healthcare provider about any other drugs you may be taking.

Disease Interaction

Patients with a history of angioedema, kidney diseases, and liver diseases should not take enalapril.

Drug Interaction

El can interact with diuretics, potassium supplements, NSAIDs, and lithium. Alcohol can also increase the side effects of this medication.

Food Interactions

No food interactions have been reported with enalapril.

Pregnancy Use

El should be used during pregnancy only if clearly needed. It is not recommended for use in nursing mothers.

Lactation Use

It is not recommended for use in nursing mothers.

Acute Overdose

Acute overdose of enalapril can result in hypotension, tachycardia, and renal failure. If an overdose is suspected, contact a poison control center as soon as possible.

Contraindications

El is contraindicated in patients who have a history of angioedema, kidney diseases, liver diseases, and allergies to ACE inhibitors.

Use Direction

El should be taken orally with or without food as directed by your doctor. It may take several weeks for the full effects to be noticed.

Storage Condition

Store the medication at room temperature, away from heat and moisture.

Volume of Distribution

The volume of distribution for enalapril is 8.5 L/kg.

Half Life

The half-life of enalapril is 2-4 hours.

Clearance

The clearance of enalapril is 5.5 mL/min/kg.

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