Durasic

Durasic Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Durasic is a brand name. Its generic name is Fentanyl.

Durasic Introduction

Durasic is an opiate analgesic medication prescribed for the treatment of chronic pain. It belongs to a class of medications known as opiate agonists, which work by binding to opioid receptors in the brain to reduce pain signals. It interacts with specific opioid receptors in the brain to produce pain relief. It is often used as an epidural or intrathecal injection prior to surgery as well as for injection into tissue surrounding the spinal cord before and after back surgery. Durasic is also available in various oral, topical, transdermal, sublingual, intrathecal, and oral transmucosal forms.

Uses For Durasic

Durasic is indicated for the management of both acute and chronic pain. It is often prescribed for the treatment of pain associated with cancer, chronic musculoskeletal disorders, and nerve damage. It may also be used to treat pain not responding to other opioids. Durasic is also used as an intravenous or intramuscular injection prior to surgery for the relief of pain or as an epidural or intrathecal injection prior to surgery. Durasic can also be used to provide anesthetic effects.

Mechanism of Action

Durasic works by binding to specific opioid receptors in the brain, which are involved in the control of pain signals. Durasic interacts with the mu-opioid receptor, which is responsible for the analgesic effects of fentanyl. It is also a potent and relatively selective partial agonist at mu opioid receptors and only weakly activates kappa opioid receptors. Durasic also increases the release of GABA, a neurotransmitter involved in the management of pain signals.

How Long Does it Take to Work?

Most forms of fentanyl take effect quickly, and the effects can last up to four hours. The duration of effect will depend on the specific formulation of the medication and the dosage. The effect of intravenous and intramuscular injections can take effect within minutes, while transdermal patches may take up to 12 hours for the full effect to be felt. The full effect of orally administered fentanyl can take up to 30 minutes for the onset of action.

Absorption

Durasic is rapidly and well absorbed after oral, intramuscular, rectal, buccal, transdermal and epidural administrations. Durasic is rapidly absorbed across all mucosal surfaces, including the nose, mouth, rectum, vagina and urethra. When administered by injection, fentanyl is rapidly absorbed, and reaches peak plasma concentrations within 30 minutes.

Route of Elimination

Durasic is eliminated primarily by renal excretion, with a terminal elimination half-life of approximately 10 hours. The elimination half-life of fentanyl may increase in patients with renal impairment, and can reach up to 14 hours.

Dosage

Durasic is available in various formulations and strengths. The dosage of fentanyl depends on the individual's medical condition, response to therapy, and other medications they may be taking, as well as the route of administration. The standard initial dose of fentanyl for an adult is 100 mcg administered intramuscularly. When administered by injection, the dose usually ranges from 25 to 50 mcg. Transdermal patches can be used in doses ranging from 25 to 100 mcg per hour.Transmucosal doses range from 0.5 to 2 mg.

Administration

Durasic can be administered by various routes, including oral, intrathecal, epidural, intramuscular, sublingual, and transdermal. Oral tablets, transmucosal tablets, transmucosal solutions, rectal suppositories, and transdermal patches are available. Durasic can also be administered intravenously and intramuscularly. Intravenous and intramuscular injections should be administered slowly over a period of at least three minutes, while transdermal patches should be applied to a dry, clean area of skin at least twice weekly.

Side Effect

The most commonly reported side effects include nausea, vomiting, constipation, drowsiness, dizziness, dry mouth, sweating, difficulty sleeping, confusion, headache, and rashes. Serious side effects may include respiratory depression, constipation, euphoria, and seizures. Durasic also has the potential to be abused and can cause addiction, dependence, and withdrawal symptoms.

Toxicity

Durasic is a potent opioid, and, like all other opioids, carries the potential for severe toxicity if used in excess. Durasic is highly addictive and can quickly lead to dependence and abuse. Overdose of fentanyl can result in severe respiratory depression, coma, and death.

Precaution

Patients taking fentanyl should be monitored closely for symptoms of addiction, abuse, and overdose. Durasic should be used with caution in patients with renal or hepatic impairment, and patients taking other medications that affect the metabolism of fentanyl. Durasic should not be taken at the same time as alcohol or other CNS depressants as this can significantly increase the risk of overdose. Patients should also be advised to avoid driving or operating heavy machinery while taking fentanyl.

Interaction

Durasic may interact with other medications, including other opioids, certain anticholinergic drugs, and certain antidepressants. Durasic may also interact with alcohol or other central nervous system depressants, which can increase the risk of overdose. Patients should inform their healthcare provider of all medications they are taking, including over-the-counter medications, vitamins, and herbal supplements.

Disease Interaction

Durasic may interact with certain medical conditions, including respiratory and renal impairment. Patients should inform their healthcare provider of any medical conditions they may have prior to taking fentanyl. Durasic should be used cautiously in patients with kidney or liver disease, or those taking medications that may affect the metabolism of fentanyl.

Drug Interaction

Durasic may interact with other medications, including other opioids, certain anticholinergic drugs, and certain antidepressants. Patients should inform their healthcare provider of all medications they are taking, including over-the-counter medications, vitamins, and herbal supplements. Durasic may also interact with alcohol or other central nervous system depressants, which can increase the risk of overdose.

Food Interaction

Durasic should not be taken with food or grapefruit juice as this can increase the risk of overdose. It should also be used with caution if taken with alcohol or other central nervous system depressants, as this can increase the risk of overdose. Patients should inform their healthcare provider of all medications they are taking, including over-the-counter medications, vitamins, and supplements.

Pregnancy Use

Durasic is not recommended for use during pregnancy due to the risk of harm to the fetus. Durasic may also be less effective in decreasing pain in pregnant patients. Women of child-bearing potential should use effective contraception while taking fentanyl. If pregnancy occurs while taking fentanyl, the patient should be advised to discontinue the medication and the risks and benefits of the medication should be discussed with the patient's healthcare provider.

Lactation Use

Durasic has not been studied in breastfeeding women and is not recommended for use as the drug is excreted into breast milk. Patients should inform their healthcare provider if they are breastfeeding or planning to breastfeed prior to taking fentanyl.

Acute Overdose

An acute overdose of fentanyl can be potentially life-threatening and medical attention should be sought immediately. Symptoms of an overdose may include extreme drowsiness, shallow breathing, pinpoint pupils, nausea and vomiting, fainting, and seizures. Respiratory depression is the most serious symptom and can potentially be fatal. If suspected, patients should seek medical attention immediately.

Contraindication

Durasic is contraindicated in patients with hypersensitivity to fentanyl or any of its components. It is also contraindicated in patients with renal or hepatic impairment, and patients taking medications that may affect the metabolism of fentanyl. Durasic should also not be used in patients with a history of substance abuse or addiction.

Use Direction

Durasic should be used exactly as prescribed by your healthcare provider. Patients should not take larger or smaller doses of fentanyl than prescribed and should take the medication for the shortest amount of time necessary. Durasic should not be taken more frequently than prescribed or with other medications. Patients should inform their healthcare provider if the medication is not relieving their pain, or if they experience unusual side effects.

Storage Condition

Durasic should be stored at room temperature in a tightly sealed container. It should be kept away from moisture and light and out of the reach of children. It should not be stored in the refrigerator or the freezer. Any unused or expired fentanyl should be disposed of in a safe manner, according to the instruction of the healthcare provider.

Volume of Distribution

The volume of distribution of fentanyl is 1.9 L/kg.

Half Life

The half-life of fentanyl is approximately 0.5 to 1.5 hours.

Clearance

The clearance of fentanyl is approximately 0.9 L/kg/hr.

Here you find in details version of Durasic

Some Frequently Asked Questions About Durasic

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What is fentanyl?

Durasic is a powerful synthetic opioid analgesic that is similar to morphine but is 50 to 100 times more potent. It is a schedule II prescription drug, and it is typically used to treat patients with severe pain or to manage pain after surgery.

Where is fentanyl found?

Durasic is a prescription drug that is legally manufactured and distributed. It is typically found in healthcare settings, like hospitals and pharmacies. However, fentanyl is also illegally manufactured and sold on the street.

What does fentanyl look like?

Durasic is a white, odorless, bitter-tasting powder. It can also be pressed into tablets, mixed into liquids, or sold as transdermal patches, lozenges, or nasal sprays.

What are the side effects of using fentanyl?

The most common side effects of using fentanyl include nausea, vomiting, constipation, dry mouth, drowsiness, dizziness, confusion, and headache. It can also cause respiratory depression, which can be fatal.

Is fentanyl addictive?

Yes, fentanyl is a highly addictive drug. It has a high potential for abuse and addiction due to its incredibly strong analgesic effects. People who use fentanyl for an extended period of time may develop a physical and psychological dependence on the drug.

What are the long-term effects of abusing fentanyl?

Long-term abuse of fentanyl can have serious effects on the body, including heart and lung damage, liver and kidney damage, gastrointestinal problems, and an increased risk of overdose. Abusing fentanyl can also lead to an increased tolerance to the drug, which can make it more difficult to quit using it.

What symptoms indicate an overdose on fentanyl?

The most common symptoms of a fentanyl overdose include slow or shallow breathing, extreme drowsiness, confusion, clammy skin, and loss of consciousness. If someone is experiencing these symptoms, call 911 immediately.

Can fentanyl be detected in a drug test?

Yes, fentanyl can be detected in a urine, blood, saliva, or hair sample. The test will depend on the type of drug test being used. Durasic can usually be detected in urine and blood tests for up to 48 hours after ingestion and in saliva samples for up to 24 hours.

What is the legal status of fentanyl?

Durasic is a Schedule II controlled substance in the United States. This means that it has a high potential for abuse and addiction, and it requires a prescription from a doctor for use. Possessing and distributing fentanyl without a prescription is illegal and can result in criminal charges.

Is there a safe way to use fentanyl?

Yes, when taken as prescribed by a doctor, fentanyl can be a safe and effective way to manage chronic or severe pain. However, it is important to follow all instructions for taking the drug and to never take more than prescribed. Taking too much fentanyl can be dangerous and even fatal.

Can you get high from fentanyl?

Yes, due to its highly potent opioids effects, fentanyl can produce a feeling of euphoria. Taking fentanyl without a prescription, or taking more than prescribed, can produce a more intense high, but it can also be extremely dangerous and can lead to overdose and even death.

What is the lethal dose of fentanyl?

The lethal dose of fentanyl can vary from person to person. However, as little as 2 milligrams of fentanyl can be lethal in an average-sized adult. It is important to never take more than prescribed, as taking too much fentanyl can be fatal.

How can fentanyl be taken?

Durasic can be taken in a variety of ways, including orally (by swallowing a pill or liquid), as an injection, in a transdermal patch, as a lozenge, or as a nasal spray. It is typically prescribed by a doctor and can be taken as prescribed for the treatment of chronic or severe pain.

Can fentanyl be snorted?

Yes, fentanyl can be snorted. This is referred to as insufflation and is a dangerous way to take the drug. Snorting fentanyl can cause a person to become addicted more quickly, and can also lead to an overdose due to the drug entering the bloodstream faster.

What is the difference between fentanyl and morphine?

Durasic is a synthetic opioid analgesic that is similar to morphine, but is 50 to 100 times more potent. Morphine is an older medication and is typically used to treat mild to moderate pain. Durasic is usually prescribed for bleeding pain or pain that is not responding to other opioid medications.

What is fentanyl laced heroin?

Durasic laced heroin is heroin that is mixed with fentanyl, a much more powerful opioid. It is typically found on the street and is associated with a high risk of addiction and overdose due to its high potency.

Is fentanyl stronger than oxycodone?

Yes, fentanyl is significantly stronger than oxycodone. Durasic is 50 to 100 times more potent than morphine, while oxycodone is only 2 to 4 times more potent than morphine.

What is the half-life of fentanyl?

The half-life of fentanyl is typically around 8 to 12 hours, however, this can vary from person to person. After 8 to 12 hours, half of the drug is removed from the body.

What is fentanyl citrate?

Durasic citrate is an opioid analgesic that is typically used for the treatment of pain. Durasic citrate is a mix of fentanyl powder and an inert powder, such as citric acid. It is usually found in a form that can be pressed into a pill, or mixed into a liquid.

Can you die from fentanyl?

Yes, it is possible to die from a fentanyl overdose. Taking too much fentanyl can lead to a slowed or stopped heart rate and respiratory arrest, both of which can be fatal. An overdose is a medical emergency and emergency medical care should be sought immediately.

Can fentanyl be injected?

Yes, fentanyl can be injected. However, it is a very dangerous and risky practice that should only be done under the supervision of a medical professional. Injecting fentanyl can increase the risk of addiction and overdose.

Can fentanyl be used while pregnant?

No, fentanyl should not be used while pregnant. Durasic can pass through the placenta and can enter the fetus, which can cause serious harm to the infant. There is also a risk of severe respiratory depression and withdrawal in the baby when the mother stops taking the drug.

What is the street name for fentanyl?

Durasic is known by a variety of street names, including apache, China girl, goodfella, Tango and Cash, and jackpot. It is important to be aware of these names in order to identify when someone may be using or selling fentanyl illegally.

What is the difference between fentanyl and heroin?

The main difference between fentanyl and heroin is their effects on the body. Durasic is a synthetic opioid analgesic that is 50 to 100 times more potent than morphine, while heroin is an opioid derived from the opium poppy plant. Both drugs can produce a feeling of euphoria and can be highly addictive, but fentanyl is more potent and carries a higher risk of overdose.

What is perfentanyl?

Perfentanyl is a synthetic opioid analgesic that is similar to fentanyl. It is made from the same compound as fentanyl but is 7 to 10 times more potent than fentanyl. Perfentanyl is usually injected and is commonly abused on the street.

What is fentanyl analog?

A fentanyl analog is a synthetic drug that is structurally similar to fentanyl, but may be more or less potent than fentanyl. Durasic analogs are usually produced illegally and are sold on the street. They are extremely dangerous and can cause an overdose more quickly than other drugs.

Is fentanyl illegal?

No, fentanyl is not illegal. It is a Schedule II controlled substance in the United States, which means it requires a prescription from a doctor for use. Possessing and distributing fentanyl without a prescription is illegal and can result in criminal charges.

What is the difference between fentanyl and hydrocodone?

The main difference between fentanyl and hydrocodone is their effects on the body. Durasic is a synthetic opioid analgesic that is 50 to 100 times more potent than morphine, while hydrocodone is a semi-synthetic opioid that is only slightly more potent than morphine. Durasic is typically prescribed for severe pain, while hydrocodone is usually prescribed for mild to moderate pain.

What are the long-term effects of fentanyl use?

Long-term use of fentanyl can have serious effects on the body, including heart and lung damage, liver and kidney damage, gastrointestinal problems, and an increased risk of overdose. It can also lead to an increased tolerance to the drug, which can make it more difficult to quit using it. Long-term use of fentanyl can also lead to physical and psychological dependence.

What are the signs of fentanyl withdrawal?

The signs of fentanyl withdrawal can vary from person to person. Common signs include nausea, vomiting, diarrhea, abdominal cramps, chills, sweating, muscle aches, and insomnia. More serious signs can include anxiety, depression, agitation, and confusion.

Can fentanyl be smoked?

Yes, fentanyl can be smoked. Smoking fentanyl can increase the risk of addiction and overdose due to the drug entering the bloodstream faster. It is important to never smoke fentanyl without a prescription and to never take more than prescribed as taking too much fentanyl can be fatal.

What is a fentanyl patch?

A fentanyl patch is a transdermal patch that is used to deliver continuous pain relief over an extended period of time. The patch contains fentanyl, a powerful opioid analgesic, and is prescribed for treatment of chronic and severe pain.

What is Acetyl Durasic?

Acetyl Durasic is a synthetic opioid analgesic that is similar to fentanyl but is twice as potent. It is an illegal drug that is typically sourced on the street and can be extremely dangerous due to its potency. Acetyl Durasic can cause a severe overdose and can even be fatal.

Why is fentanyl dangerous?

Durasic is dangerous because it is a highly potent opioid that can cause an increased risk of addiction and overdose. It is a schedule II controlled substance and should only be taken as prescribed by a doctor. Abusing fentanyl can lead to an increased tolerance and an increased likelihood of an overdose.

What drug class is fentanyl in?

Durasic is in the drug class of opioid analgesics. It is a powerful synthetic opioid that is similar to morphine but is 50 to 100 times more potent. It is a schedule II controlled substance in the United States, which means it requires a prescription from a doctor for use.