Duramorph, a brand name for a formulation containing essential Morphine, is widely used for various health benefits. This guide provides comprehensive information on the uses, dosage, side effects, and mechanism of action of Duramorph, as well as insights into how long it takes to work. Understanding these aspects can help you make informed decisions about its use and effectiveness.

Duramorph Introduction

Duramorph is an opiate pain reliever and a common treatment for moderate to severe pain. It is known by various trade names, including Kadian, Avinza, Oramorph SR, Roxanol, and MS Contin.

Uses for Duramorph

Duramorph can be used for the treatment of moderate to severe pain in a variety of medical conditions, including but not limited to cancer pain, post-surgical pain, pain caused by burns or injuries, and chronic pain. Duramorph is sometimes used to treat opioid addiction, or in palliative medicine to treat symptoms of terminal illnesses like AIDS or cancer.

Mechanism of Action

Duramorph works by attaching to opioid receptors in the brain, spinal cord, and gastrointestinal tract. This action blocks pain signals and helps to reduce the perception of pain. Duramorph also increases the level of feel-good chemicals like dopamine and serotonin, which helps to further reduce pain and improve the patient’s overall wellbeing.

How Long Does It Take To Work?

Duramorph generally takes 15-30 minutes to take effect. However, the timing may vary depending on the individual’s metabolism and the route of administration.


Duramorph is highly lipophilic and is readily absorbed after administration. The rate of absorption depends on the dosage form and the route of administration.

Route of Elimination

Duramorph is mainly eliminated through the kidneys, with some minor contribution by the liver and intestine. The exact elimination route may vary by individual and may also be affected by the route of administration.

Dosage and Administration Information

Duramorph is available in a variety of forms, including tablets, capsules, syrups, injections, and suppositories. Generally, an adult dose of morphine ranges from 10 to 30 mg per day, although it can be higher depending on the individual’s tolerance and the type of pain being treated. It is important to note that the dose of morphine must be adjusted carefully under the guidance of a medical professional.

Side Effects

Duramorph can cause a variety of side effects, including nausea, vomiting, constipation, drowsiness, confusion, dizziness, decreased sex drive, dry mouth, sweating, and rash. If any of these effects are severe or persistent, or if any new or unusual effects occur, contact a doctor for advice.


Duramorph is generally considered safe when used as directed. However, misuse or abuse of the drug can lead to life-threatening side effects, such as respiratory depression and coma. It is important to take the medication exactly as prescribed and to never take more than the recommended dose.


Duramorph should be used with caution in patients with kidney or liver disease, as well as in patients taking other medications that depress the central nervous system. It should also not be combined with alcohol or other illicit drugs. Before taking morphine, it is important to tell the doctor about any allergies or medical conditions, including any use of non-prescription drugs.


Duramorph can interact with a variety of medicines, including tranquilizers, sleeping pills, sedatives, antihistamines, antidepressants, or muscle relaxants. Alcohol and recreational drugs can increase the risk of side effects. Speak with the doctor about any medications or supplements being taken before starting on morphine.

Disease Interactions

Duramorph should be used with caution in patients with pre-existing breathing problems, heart disease, or a history of substance abuse. Patients with a history of medical conditions such as seizures, head trauma or brain damage should discuss these issues with the doctor before taking morphine.

Drug Interactions

Duramorph can interact with other drugs, including amphetamines, antacids, barbiturates, certain birth control pills, cholesterol medications, and drugs for treating depression, anxiety, or seizures. Speak with the doctor about any other prescription or non-prescription drugs being taken before starting on morphine.

Food Interactions

Duramorph may interact with certain foods such as grapefruit or grapefruit juice. Avoid eating grapefruit or drinking grapefruit juice while taking morphine.

Pregnancy Use

Duramorph should not be used during pregnancy unless it is considered essential by the doctor. There is a risk of harm to the fetus from exposure to morphine, so it should only be used if the benefits outweigh the risks.

Lactation Use

Duramorph should be used with caution in lactating mothers. There is a risk of harm to the infant from exposure to morphine.

Acute Overdose

An acute overdose of morphine can be fatal. Symptoms of an overdose include slow or shallow breathing, confusion, coma, and severe drowsiness. Seek immediate medical attention if an overdose is suspected.


Duramorph should not be used in patients who are hypersensitive or allergic to the drug, or to any of the inactive ingredients in the formulation. It should also not be used in patients with severe breathing problems or a head injury.

Use Direction

Duramorph should be taken as directed by a doctor. It is important to follow the specific directions given by the doctor and to never take more than the recommended dose. The tablet or liquid should be taken with food or milk in order to reduce the chance of stomach irritation.

Storage Condition

Duramorph should be stored in a tightly sealed container at room temperature away from light and moisture. It should be kept out of the reach of children.

Volume of Distribution

Duramorph has a volume of distribution of 2-3 liters/kilogram. This means that it is distributed primarily in the body tissues, with a smaller portion found in the blood plasma.

Half Life

The half life of morphine is 1.5 to 7 hours. This means that it takes up to 7 hours for the drug to be reduced to half its original amount in the body.


Duramorph has a clearance rate of 1-1.5 ml/min/kg. This means that it is cleared from the body at a rate of 1-1.5 ml per minute per kilogram of body weight.

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