Dotra, a brand name for a formulation containing essential Drotaverine, is widely used for various health benefits. This guide provides comprehensive information on the uses, dosage, side effects, and mechanism of action of Dotra, as well as insights into how long it takes to work. Understanding these aspects can help you make informed decisions about its use and effectiveness.

Dotra Introduction

Dotra is a drug belonging to the class of spasmolytic antispasmodics. This drug is mainly used to treat abdominal cramps, colic pain, stomachache, menstrual pain and works by relaxing the muscles of the digestive tract and is widely used in adults, pediatric and elderly patients.

Dotra Uses

Dotra is used for the symptomatic treatment of abdominal pain which is caused by gastrointestinal spasms and cramping. It is also used to treat conditions such as stomach ulcer, colic pain in infants, renal colic, biliary colic and gall bladder pain.

Dotra Mechanism of Action

Dotra is a spasmolytic antispasmodic drug which works by relaxating the smooth muscles of the wall of the digestive tract. It mainly works on the anticholinergic receptors, calcium channels and constrictor mediators present on the gut wall.

How Long Does It Take to Work?

Dotra takes around 15-30 minutes to take effect in relieving abdominal cramps and other associated pains. It can act as a fast-acting pain reliever and produce almost instant relief.

Dotra Absorption

Dotra is well-absorbed in the gastrointestinal tract and reaches its peak plasma concentration within 1-2 hours after oral administration.

Dotra Route of Elimination

Dotra is mainly eliminated through the kidneys via urine in an unchanged form. It's elimination half-life is around 2 to 2.5 hours.

Dotra Dosage

The dose of Dotra depends on the condition being treated and may vary for each individual patient. The usual dose for adults is 40 - 80mg 3-4 times a day while the usual dose for pediatric patients is 0.2 - 0.4mg per kg body weight 3-4 times a day. This drug must be taken by mouth with a full glass of water or as per the directions of a doctor.

Dotra Administration

Dotra is available in tablet form and is best taken one hour before or two hours after meals. It is important that this medicine should be taken regularly as prescribed for optimal effect.

Dotra Side Effects

  • Headache
  • Dizziness
  • Nausea
  • Stomach upset
  • Loss of appetite
  • Diarrhea
  • Heartburn

Dotra Toxicity

Dotra has low toxicity in humans and is only associated with mild to moderate side effects when taken in high doses.

Dotra Precaution

  • This medicine should be used with caution in pregnant and nursing mothers.
  • Patients having a history of glaucoma, heart diseases, hepatic or renal diseases should use this medicine cautiously.
  • Alcohol consumption should be avoided while taking Dotra.
  • This medication can interfere with the ability to drive or operate machinery.

Dotra Interaction

Dotra may interact with other medications such as anticoagulants, anticholinergic drugs, antihistamines, tricyclic antidepressants and diuretics.

Dotra Disease Interaction

Dotra may interact with certain medical conditions such as hepatic cirrhosis, prostatic hypertrophy, pyloric stenosis, hepatic impairment, hyperthyroidism, and Parkinson’s Disease.

Dotra Drug Interaction

Dotra may interact with certain drugs such as barbiturates, narcotics, benzodiazepines, anticholinergics, phenothiazines, and MAOIs (monoamine oxidase inhibitors).

Dotra Food Interactions

Dotra should not be taken with high-fat foods as it can reduce its absorption.

Dotra Pregnancy Use

Dotra should be used with caution in pregnant women. It is recommended to take this medicine only if clearly needed during pregnancy.

Dotra Lactation Use

Dotra can pass through breast milk and can harm an infant. Therefore, it is not recommended to take it during lactation.

Dotra Acute Overdose

Symptoms of overdose include dizziness, drowsiness, confusion, nausea, vomiting and stomach pain. Seek immediate medical attention in case of an overdose.

Dotra Contraindication

Dotra is contraindicated in patients with hypersensitivity and severe gastrointestinal obstruction.

Dotra Use Directions

  • Take this medicine as per the directions of your doctor.
  • Take Dotra 30 minutes before meals or 2 hours afterwards.
  • Do not stop taking this medicine abruptly without informing your doctor.
  • Do not increase the dose of this medicine without consulting your doctor.

Dotra Storage Condition

Dotra should be stored at room temperature in an airtight container away from direct light and moisture.

Dotra Volume of Distribution

The volume of distribution of Dotra is approximately 42 L/kg.

Dotra Half Life

The half-life of Dotra is approximately 2-2.5 hours.

Dotra Clearance

The hepatic clearance of Dotra is approximately 2.3 L/h/kg.

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