Dolonil SR

Dolonil SR Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Dolonil SR is a brand name. Its generic name is Tramadol.

Dolonil SR

Dolonil SR, (generic name: tramadol hydrochloride), is an opioid medication used to treat moderate to severe pain. It is an opioid agonist, meaning it stimulates opioid receptors in the brain, activating them and producing an analgesic effect. Dolonil SR also works on serotonin and norepinephrine receptors, further enhancing its pain-relieving effect. Dolonil SR is available in both immediate-release and extended-release forms.

Uses For Dolonil SR

Dolonil SR is prescribed to treat moderate to severe pain in both adults and children, as well as in adolescents between the ages of 12 and 18. It is also used off-label to treat pain associated with fibromyalgia, painful neuropathy, and headaches. Because of its opiate-like effects, Dolonil SR is sometimes prescribed for the treatment of opioid dependence.

Mechanism Of Action

Dolonil SR works by binding to opioid receptors in the brain and spinal cord, and increasing the activity of serotonin (which helps reduce the pain signals sent to the brain). Dolonil SR also binds to the norepinephrine receptor, which further enhances its pain-relieving effect. The combination of its opioid and monoamine agonism is responsible for its analgesic effects.

How Long Does It Take To Work?

Dolonil SR typically begins to work within 30 minutes to an hour of being taken. The duration of its effects usually last about 4-6 hours. With extended-release tablets, effects may last up to 12 hours.

Absorption

Dolonil SR is rapidly and completely absorbed from the gut into the blood stream, with peak blood levels occurring one to two hours after ingestion. It is highly soluble in water, and rapidly distributed throughout the body.

Route Of Elimination

Dolonil SR is broken down and eliminated by the liver and kidneys. About 90% of an administered dose is eliminated via the kidneys, and 10% via the bile. It typically takes 4-6 hours for tramadol to be eliminated from the body.

Dosage

Dosage of Dolonil SR depends on the task of its use. A starting dose of the medication is usually 25-50mg every four to six hours, for which the maximum dose should not exceed 400mg in a day. For treating breakthrough pain, the dose can be increased to 150-200mg per day. Extended release tablets should be taken once a day, with the maximum dose not exceeding 300mg in a day.

Administration

Dolonil SR can be taken orally or administered through an IV. Oral tablets and capsules should be taken with food to reduce the risk of gastrointestinal adverse effects. Oral liquid preparations should be administered with a specifically designed measuring device, and not with a regular teaspoon.

Side Effect

Common side effects of Dolonil SR include nausea, vomiting, drowsiness, dizziness, headache, constipation, and dry mouth. Other side effects may include difficulty urinating, loss of appetite, sweating, confusion, and itchy skin. In some cases, more serious side effects such as respiratory depression, hallucinations, and seizures can occur.

Toxicity

Dolonil SR is generally considered safe and well-tolerated when used as prescribed. But at higher doses, especially when taken with other medications that also act on the central nervous system, it can be toxic, and may lead to serious respiratory depression, comas, and even death.

Precautions

Dolonil SR should be taken with caution, especially in individuals with a history of alcohol abuse or addiction, mental illness, thyroid problems, kidney or liver disease, or a history of convulsions, seizures, or head injury. Dolonil SR should not be taken concomitantly with MAO inhibitors, muscle relaxants, sedatives or other narcotic medications.

Interaction

Dolonil SR may interact with certain medications such as anticoagulants, antidepressants, monoamine oxidase inhibitors, drugs for high blood pressure, drugs for mental illness, antihistamines, muscle relaxants, and opioids, increasing the risk of toxicity and other side effects.

Disease Interaction

Dolonil SR may interact with certain diseases such as seizure disorders, head injury, liver or kidney disease, and respiratory depression, increasing the risk of toxicity and other side effects. Patients with any of these diseases should talk to their doctor before starting tramadol therapy.

Drug Interaction

Dolonil SR can interact with several drugs, including alcohol, Monoamine Oxidase inhibitors (MAOIs), anticoagulants, sedatives, muscle relaxants, and opioids. These interactions can increase the risk of toxicity and other side effects. Patients should check with their doctor before starting or stopping any medication while taking tramadol.

Food Interactions

Dolonil SR should be taken with food to reduce the risk of gastrointestinal adverse effects. Grapefruit juice should be avoided when taking tramadol, as it can increase the absorption of the drug and potentially increase its toxicity. Certain foods such as aged cheese, red wine, and pickled or smoked meats can also interact with tramadol.

Pregnancy Use

Dolonil SR is not recommended for use in pregnant women. It is not known whether the drug is harmful to developing babies or if it passes into breast milk. Women who are pregnant or breastfeeding should talk to their doctor before taking tramadol.

Lactation Use

Dolonil SR should not be used during breastfeeding. It is not known whether the drug is harmful to developing babies or if it passes into breast milk. Women who are breastfeeding should talk to their doctor before taking tramadol.

Acute Overdose

Overdose of tramadol can lead to respiratory depression, comas, and even death. Symptoms of an overdose can include pinpoint pupils, confusion, slowed breathing, seizure, and loss of consciousness. Treatment for an overdose may include administration of naloxone, an opioid antagonist, or other supportive care measures.

Contraindication

Dolonil SR is contraindicated in patients who are hypersensitive to it or any of its components. It is also contraindicated in patients who are taking MAO inhibitors, strong CYP3A4 inhibitors, and certain opioid drugs such as meperidine. Additionally, tramadol should not be taken in combination with alcohol or other CNS depressants.

Use Direction

Dolonil SR should be taken as directed by a physician. It should be taken with food to reduce the risk of gastrointestinal adverse effects. The dosage of tramadol should be adjusted based on patient’s response and symptoms. It should not be taken concomitantly with MAO inhibitors, muscle relaxants, sedatives, or other narcotic medications.

Storage Condition

Dolonil SR should be stored at room temperature in a light-resistant, child-resistant container. It should be kept away from heat and moisture, and out of the reach of children and pets.

Volume Of Distribution

Dolonil SR has a volume of distribution of 0.4L/kg, meaning that 0.4L of the drug is distributed throughout the body for every kg of the patient’s weight.

Half Life

Dolonil SR has a half-life of 4-6 hours, meaning it takes 4-6 hours for half of the drug to be eliminated from the body.

Clearance

Dolonil SR has a clearance rate of 0.11L/kg/hour, meaning that 0.11L of the drug is eliminated from the body every hour for every kg of the patient’s weight.

Here you find in details version of Dolonil SR

Some Frequently Asked Questions About Dolonil SR

What is Dolonil SR?

Dolonil SR is an opioid-type pain reliever (analgesic) used to treat moderate to moderately severe pain. It is available in both immediate-release and extended-release formulations.

What is the generic name of Dolonil SR?

Dolonil SR's generic name is Ultram.

What is the mechanism of action of Dolonil SR?

Dolonil SR works by binding to and activating opioid receptors located in the brain, which helps reduce the perception of pain.

Is Dolonil SR a controlled substance?

Yes, Dolonil SR is classified as a Schedule IV controlled substance in the United States, suggesting that it has a low potential for abuse.

How fast does Dolonil SR work?

Dolonil SR works within 30 minutes of taking a dose and its effects can last up to 4-6 hours.

How should Dolonil SR be taken?

Dolonil SR should be taken exactly as prescribed by the doctor. It can be taken with or without food but should not be crushed, split, or chewed before taking.

What are the side effects of Dolonil SR?

The most common side effects of Dolonil SR include nausea, vomiting, constipation, headache, dizziness, drowsiness, and dry mouth.

Can I take acetaminophen and Dolonil SR together?

Yes, acetaminophen and Dolonil SR can be taken together as long as the total daily dose of acetaminophen does not exceed 4,000 milligrams.

What are the signs of an overdose of Dolonil SR?

Signs of an overdose of Dolonil SR include extreme drowsiness, confusion, shallow breathing, faster heart rate, nausea, vomiting, and fainting.

Can Dolonil SR be used for back pain?

Yes, Dolonil SR is often prescribed for the treatment of back pain.

Is Dolonil SR addictive?

Yes, Dolonil SR can be addictive when taken in large amounts or for long periods of time.

What should I do if I forget to take a dose of Dolonil SR?

If you forget to take a dose of Dolonil SR, take it as soon as you remember, but do not double your dose. Call your doctor if you have any questions or concerns.

Can Dolonil SR be taken with alcohol?

No, Dolonil SR should not be taken with alcohol as it can increase the risk of side effects such as extreme drowsiness and respiratory depression.

Should I avoid caffeine while taking Dolonil SR?

Yes, as caffeine can increase the risk of nervousness, difficulty sleeping, and fast or irregular heartbeat.

Is Dolonil SR safe for long-term use?

Dolonil SR is generally considered safe for short-term use, but its effects can diminish with long-term use, increasing the risk of addiction and overdose.

Can Dolonil SR be taken during pregnancy?

Dolonil SR should not be taken during pregnancy as it can cause harm to the fetus.

Can I take Dolonil SR if I have a history of drug abuse?

No, Dolonil SR should not be taken if you have a history of drug abuse as it can be addictive and could cause relapse.

Will Dolonil SR show up on a drug test?

Yes, Dolonil SR may show up on a drug test, though the results may vary depending on the type of test.

Can I take Dolonil SR if I have liver or kidney disease?

Dolonil SR should be used with caution in patients with a history of liver or kidney disease, as they may be more sensitive to its effects.

Can I take Dolonil SR with anti-anxiety medications?

No, Dolonil SR should not be taken with anti-anxiety medications, as it may increase the risk of adverse reactions.

What should I do if I experience any side effects from Dolonil SR?

If you experience any side effects from Dolonil SR, contact your doctor as soon as possible.

What other pain relievers can be taken with Dolonil SR?

Dolonil SR can be taken with other non-opioid pain relievers such as ibuprofen and acetaminophen.

What is the maximum daily dose of Dolonil SR?

The maximum daily dose of Dolonil SR is 400 milligrams per day for adults.

Does Dolonil SR cause constipation?

Yes, constipation is a common side effect of Dolonil SR.

Can I take Dolonil SR and Dolonil SR Plus together?

No, Dolonil SR and Dolonil SR Plus should not be taken together as it may increase the risk of adverse reactions.

Can Dolonil SR be taken for headaches?

Yes, Dolonil SR is often prescribed for the treatment of headaches.

Is Dolonil SR ever prescribed for arthritis?

Yes, Dolonil SR is sometimes prescribed for the treatment of arthritis.

Does Dolonil SR interact with other medications?

Yes, Dolonil SR may interact with other medications, so it is important to discuss any other medications you are taking with your doctor before taking Dolonil SR.

Can Dolonil SR be taken for menstrual cramps?

Yes, Dolonil SR can be prescribed for the treatment of menstrual cramps.

Can Dolonil SR be crushed for easier swallowing?

No, Dolonil SR should not be crushed before taking because the medication may be released too quickly, leading to increased risk of side effects.

What other conditions can Dolonil SR be used to treat?

Dolonil SR may be prescribed to treat chronic pain, fibromyalgia, and neuropathic pain, among other conditions.

Can I take Dolonil SR while breastfeeding?

No, Dolonil SR should not be taken while breastfeeding as it can be passed through breast milk and could cause harm to a nursing baby.

Can Dolonil SR be taken with anti-depressants?

Yes, Dolonil SR can be taken with certain types of anti-depressants, but should not be taken with monoamine oxidase inhibitors (MAOIs).

Can Dolonil SR be taken with vitamins or supplements?

Yes, Dolonil SR can be taken with certain vitamins and supplements, but it is important to discuss any medications you are taking with your doctor before taking Dolonil SR.

Can Dolonil SR be taken with antihistamines?

Yes, Dolonil SR can be taken with certain antihistamines, but it is important to check with your doctor before taking any medication.

Can I take Dolonil SR with other pain relievers?

No, Dolonil SR should not be taken with other opioid-type pain relievers as this increases the risk of adverse reactions and overdose.

Is Dolonil SR metabolized by the liver?

Yes, Dolonil SR is metabolized in the liver and it is important to discuss any history of liver or kidney disease with your doctor before taking Dolonil SR.

How long will Dolonil SR stay in my system?

Dolonil SR can stay in the system for up to 24 hours after the last dose.

What should I do if I miss a dose of Dolonil SR?

If you miss a dose of Dolonil SR, take it as soon as you remember, but do not double your dose. Call your doctor if you have any questions or concerns.

Can I take Dolonil SR while taking other medications?

Yes, Dolonil SR can be taken with certain medications, but it is important to discuss any medications you are taking with your doctor before taking Dolonil SR.

Does Dolonil SR affect blood pressure?

Yes, Dolonil SR may cause an increase in blood pressure, so it is important to talk to your doctor if you have any concerns.

What is Dolonil SR HCL?

Dolonil SR HCL (hydrochloride) is a prescription medication used to treat pain. It is available in both immediate-release and extended-release formulations.

What are the withdrawal symptoms of Dolonil SR?

The withdrawal symptoms of Dolonil SR may include insomnia, agitation, anxiety, nausea, vomiting, sweating, and runny nose.

Can Dolonil SR cause hallucinations?

Yes, Dolonil SR can cause hallucinations, especially at higher doses.

Is Dolonil SR the same as Vicodin?

No, Dolonil SR and Vicodin are different medications. Dolonil SR is an opioid-type pain reliever while Vicodin is a combination of an opioid and acetaminophen.

Can Dolonil SR be taken with other medications for pain?

Yes, Dolonil SR can be taken with other medications for pain, but it is important to discuss any medications you are taking with your doctor before taking Dolonil SR.