Dogrel

Dogrel Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Dogrel is a brand name. Its generic name is Clopidogrel.

Introduction

Dogrel is an antiplatelet medication used to reduce the risk of stroke and cardiovascular deaths in people with heart disease. It is also used to reduce the risk of recurring chest pain caused by a heart attack. Dogrel works by preventing platelets in the blood from sticking together and forming clots that can lead to a stroke or heart attack.

Uses for

Dogrel is used to reduce the risk of stroke and cardiovascular death in people with existing heart disease or who are at high risk of developing heart disease. It is also used to reduce the risk of recurrent chest pain caused by a heart attack. It is not used to treat chest pain when it occurs.

Mechanism of Action

Dogrel prevents platelets from sticking together and forming clots that can lead to a stroke or heart attack. It does this by inhibiting the action of an enzyme called platelet activating factor (PAF). By blocking PAF, clopidogrel prevents the platelets from clumping together, which reduces the risk of stroke and heart attack.

How Long Does It Take To Work?

Dogrel usually begins to work within 1 week of starting treatment. However, it may take up to 4 weeks for the full benefits of the medication to be seen.

Absorption

Dogrel is rapidly and completely absorbed from the gastrointestinal tract after oral administration. The maximum plasma concentration is achieved 1 to 2 hours after oral administration.

Route of Elimination

Dogrel is eliminated primarily by the liver. It is metabolized by the cytochrome P450 enzymes CYP2C19 and CYP3A4 and excreted in the feces. A small amount is also excreted in the urine.

Dosage

Dogrel is taken orally in tablet form. The usual adult dose is 75 mg once daily without regard to meals. Dosage may be increased to 150 mg daily in some patients. The dose should not exceed 150 mg per day. Your doctor may adjust your dose based on your blood work or other medications you are taking.

Administration

Dogrel should be taken with food. Swallow the tablet whole with a full glass of water. Do not break, crush, or chew the tablet.

Side Effect

Common side effects of Dogrel include headache, dizziness, nausea, vomiting, diarrhea, constipation, rash, and fatigue. More serious side effects may include anemia, pancreatitis, gingival bleeding, heart rhythm disturbances, and thrombocytopenia.

Toxicity

Dogrel has an LD50 of 5500 mg/kg in rats. Toxicity is rare except in cases of accidental overdose or in patients with liver or kidney damage taking large doses.

Precaution

Patients taking Dogrel should avoid consuming alcohol as it can increase the risk of bleeding. Other drugs that may interact with Dogrel include aspirin, NSAIDs, and warfarin. Tell your doctor about any medications you are taking before taking Dogrel.

Interaction

Dogrel may interact with other medications, including aspirin, NSAIDs, and warfarin. Tell your doctor about any medications you are taking before taking Dogrel.

Disease Interaction

Dogrel may interact with certain diseases, such as liver or kidney damage. It is important to tell your doctor about any diseases you may have before taking Dogrel.

Drug Interaction

Certain drugs can interact with Dogrel, including aspirin, NSAIDs, and warfarin. Tell your doctor about any medications you are taking before taking Dogrel.

Food Interactions

Dogrel should be taken with food. Avoid unhealthy fats (including trans fats) as they may reduce the absorption of Dogrel and lower its effectiveness. Grapefruit and grapefruit juice may interact with Dogrel and should be avoided.

Pregnancy Use

Dogrel is classified as a Pregnancy Category C medication, which means that it is not known if it can harm an unborn baby. It is important to tell your doctor if you are pregnant or suspect you are pregnant before taking Dogrel.

Lactation Use

Dogrel should not be taken by breastfeeding women. It is not known if clopidogrel is excreted in human milk and it is not recommended for use during breastfeeding.

Acute Overdose

An overdose of clopidogrel may cause bleeding, difficulty breathing, or dizziness. If you or someone you know has taken an overdose of clopidogrel, seek immediate medical attention.

Contraindication

Dogrel should not be used in patients who are hypersensitive to it, in patients with active bleeding, or in pregnant or breastfeeding women. Dogrel should also not be used in patients who are taking anticoagulants such as warfarin.

Use Direction

Dogrel is an oral medication taken once daily without regard to meals. The usual adult dose is 75 mg once daily but your doctor may adjust your dose based on your blood work or other medications you are taking. Swallow the tablet whole with a full glass of water. Do not break, crush, or chew the tablet.

Storage Condition

Dogrel should be stored at room temperature, away from heat and direct light. It should be tightly closed in a cool, dry place.

Volume of Distribution

The volume of distribution of clopidogrel is 11 liters.

Half Life

The half life of clopidogrel is approximately 7 hours.

Clearance

The clearance of clopidogrel is 11 liters/hour.

Here you find in details version of Dogrel

Some Frequently Asked Questions About Dogrel

What is Dogrel?

Dogrel is a medication used to reduce the risk of stroke and heart attack in people who are at high risk. It is an antiplatelet drug, meaning it helps to prevent blood clots, and is often prescribed in combination with aspirin.

Who should take Dogrel?

Dogrel is commonly prescribed to those with a history of heart attack, stroke, or peripheral artery disease. It may also be recommended for those who have recently had a stent inserted, or who have unstable angina. Your doctor can advise if Dogrel is right for you.

How does Dogrel work?

Dogrel works by blocking platelets from clumping together and forming clots in the arteries. By reducing the formation of clots in the arteries, Dogrel can help to prevent heart attack, stroke and other cardiovascular events.

What are the common side effects of Dogrel?

The most common side effects of Dogrel include headache, diarrhea, nausea, indigestion, stomach pain and constipation. If any of these symptoms persist or worsen, contact your doctor as soon as possible.

Can I drink alcohol while taking Dogrel?

It is not recommended to drink alcohol while taking Dogrel as it can increase the risk of side effects. Ask your doctor if it is safe for you to drink alcohol while taking Dogrel.

When should I take Dogrel?

Dogrel is taken once daily, usually in the morning. It is important to take it at the same time each day to ensure it is effective and to help you remember to take it.

How long does it take for Dogrel to work?

Dogrel starts to work within a few hours of taking it. It may take up to two weeks for the full effects of the medication to be seen.

Can I take other medications while taking Dogrel?

Always tell your doctor or pharmacist about any medications or supplements you are taking while taking Dogrel. Some medicines may interact and cause serious side effects, so it is important to have your doctor check that it is safe to take other medications while Dogrel.

Can women take Dogrel?

Yes, women can take Dogrel, but pregnant women should not take it as it may have adverse effects on the unborn baby. It is also important to tell your doctor if you are breastfeeding as Dogrel may pass into breast milk and may harm a nursing baby.

What should I do if I forget to take my Dogrel?

If you forget to take your Dogrel, take it as soon as you remember and then take your next dose at the usual time. Do not take a double dose to make up for the missed dose.

What happens if I overdose on Dogrel?

If you take more Dogrel than prescribed, contact your doctor immediately or go to the emergency room. Overdosing on Dogrel can cause serious side effects or death.

Does Dogrel have any interactions with food or alcohol?

There are no known interactions between food and Dogrel, but alcohol can increase the risk of adverse side effects. It is not recommended to drink alcohol while taking Dogrel.

What are the most serious side effects of Dogrel?

The most serious side effects of Dogrel include difficulty breathing, signs of bleeding (nosebleeds, bleeding gums, blood in urine or stool), vision loss or changes, severe dizziness, fainting, or signs of an allergic reaction (hives, rash, itching, swelling). Seek immediate medical attention if you experience any of these symptoms.

Is there a generic form of Dogrel available?

Yes, there is a generic form of Dogrel available in the US. However, it is important to note that the generic forms may not have the same ingredients as the brand name version, and they may not be as effective. Talk to your doctor to find out more.

What is the cost of Dogrel?

The cost of Dogrel varies depending on the form and brand of the medication you choose. Talk to your doctor or pharmacist to find out the cost of your prescription.

Can I take Dogrel with other medications?

Always tell your doctor or pharmacist about any medications or supplements you are taking while taking Dogrel. Your doctor may need to adjust your dose of Dogrel if you are taking other medications, and some medicines may interact and cause serious side effects, so it is important to have your doctor check that it is safe to take other medications while taking Dogrel.

Can Dogrel be used to treat other conditions?

No, Dogrel should not be used for any condition other than those for which it is prescribed by your doctor. Do not take Dogrel for any other purpose, and never give Dogrel to someone else.

Does Dogrel cause weight gain?

Weight gain is not a common side effect of Dogrel, but it is possible. If you notice any changes in your weight while taking Dogrel, contact your doctor.

Can I take over-the-counter medication while taking Dogrel?

Always tell your doctor or pharmacist about any medications or supplements you are taking while taking Dogrel. Some over-the-counter medicines may interact with Dogrel and cause serious side effects, so it is important to have your doctor check that it is safe to take other medications while taking Dogrel.

What should I do if I have an allergic reaction to Dogrel?

If you experience any signs of an allergic reaction to Dogrel, such as rash, itching, hives, swelling, or difficulty breathing, discontinue use and contact your doctor immediately.

Can I stop taking Dogrel if I'm feeling better?

No, it is important to take Dogrel as prescribed for the duration of your treatment. Do not stop taking the medication without first consulting your doctor, as it may cause an increased risk of stroke and heart attack.

Does Dogrel cause hair loss?

Hair loss is not a common side effect of Dogrel, but it is possible. If you notice unusual hair loss while taking Dogrel, contact your doctor.

Can I take Dogrel while pregnant?

No, it is not safe to take Dogrel while pregnant as it may cause serious harm to the unborn baby. If you are pregnant, contact your doctor immediately.

Can I take Dogrel if I have kidney or liver problems?

If you have kidney or liver problems, your doctor may need to adjust your dose of Dogrel. Talk to your doctor before starting Dogrel if you have any kidney or liver issues.

What should I do if I experience severe stomach pain while taking Dogrel?

If you experience severe stomach pain while taking Dogrel, contact your doctor immediately. Severe stomach pain can be a sign of bleeding, which can be serious.

Can I take Dogrel if I have a history of bleeding disorders?

Dogrel can increase the risk of bleeding, so it is important to tell your doctor if you have a history of bleeding disorders before taking Dogrel. Your doctor can advise if it is safe for you to take this medication.

What should I do if I experience muscle weakness while taking Dogrel?

If you experience muscle weakness while taking Dogrel, contact your doctor immediately. Muscle weakness can be a sign of muscle breakdown, which can be serious.

Can I take Dogrel if I'm breastfeeding?

Talk to your doctor before taking Dogrel if you are breastfeeding. Dogrel can pass into breast milk and it may harm a nursing baby. Your doctor can advise on whether or not it is safe for you to take Dogrel while breastfeeding.

Can I take Dogrel if I have diabetes?

Yes, you can take Dogrel if you have diabetes, but your doctor may need to adjust your dose. It is important to tell your doctor if you have diabetes so they can ensure that Dogrel is safe for you.

Does Dogrel interact with other medications?

Dogrel may interact with other medications, including prescription, over-the-counter and herbal medications. Always tell your doctor or pharmacist about any medications or supplements you are taking while taking Dogrel. Some medicines may interact and cause serious side effects, so it is important to have your doctor check that it is safe to take other medications while taking Dogrel.

How long should I take Dogrel?

Your doctor will determine how long you should take Dogrel. It is important to take Dogrel for as long as prescribed in order to ensure it is effective. Do not stop taking Dogrel without first consulting your doctor.

What is the usual dose of Dogrel?

The usual dose of Dogrel is 75mg once daily. Your doctor may prescribe a different dose if needed. Always follow your doctor's instructions when taking Dogrel.

Can I take herbal supplements while taking Dogrel?

Always tell your doctor or pharmacist about any medications or supplements you are taking while taking Dogrel. Some herbal supplements may interact with Dogrel and cause serious side effects, so it is important to have your doctor check that it is safe to take other medications while taking Dogrel.

Can Dogrel cause dizziness?

Dizziness is a common side effect of Dogrel. If you experience severe or persistent dizziness, contact your doctor.

Does Dogrel cause blurred vision?

Blurred vision is not a common side effect of Dogrel, but it is possible. If you experience blurry vision while taking Dogrel, contact your doctor.

Is Dogrel effective in treating heart attack and stroke?

Dogrel is an antiplatelet drug, meaning it helps to prevent blood clots. It can reduce the risk of heart attack and stroke in those who are at high risk. Your doctor can advise if Dogrel is right for you.

Can Dogrel cause skin rash?

Skin rash is not a common side effect of Dogrel, but it is possible. If you experience a skin rash while taking Dogrel, contact your doctor.