Dixanol 270
Dixanol 270 Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Dixanol 270 is a brand name. Its generic name is Iodixanol.
Dixanol 270
Dixanol 270 is an iodinated non-ionic X-ray and ultrasound contrast media used to improve imaging of various tissues and organs. It is a highly osmotically active substance used to improve the visualization of lesions and anatomical structures during various imaging procedures, such as Computed Tomography, Magnetic Resonance Imaging, and Ultrasound.
Uses for Dixanol 270
Dixanol 270 is used to enhance visualization of organs and tissue during medical imaging studies. It is commonly used by doctors to diagnose a range of conditions, including aneurysms, vascular lesions, and other body structures and organs.
Mechanism of Action
Dixanol 270 is a kind of X-ray contrast medium, used to improve visibility of the internal organ structure during X-ray imaging. It works by increasing the apparent density of the X-ray material, which helps to obtain better quality images of internal organs. Dixanol 270 absorption is through the peritoneum, providing better visibility of the uterus, fallopian tubes, and lymph nodes.
How Long Does It Take to Work?
Dixanol 270 takes about 30 minutes to completely dissolve in the surrounding body tissues. After it dissolves, imaging results can be obtained within 30 to 60 minutes.
Absorption
Dixanol 270 is rapidly absorbed into the body tissue and is quickly metabolized by the liver. It is then eliminated in the urine.
Route of Elimination
Dixanol 270 is completely metabolized in the liver and eliminated in the urine within 24 hours of administration.
Dosage
The dose of Dixanol 270 depends on the type of procedure being performed, the body’s condition, and the response to the contrast medium. Doctors may also adjust the dose of the contrast medium to compensate for any unknown factors. In general, the recommended starting dose for adults is 6 ml - 8 ml every 15 minutes for a total of 24 ml - 32 ml for intravenous injection. Doctors may also adjust the dose depending on the results that are desired for the particular imaging procedure.
Administration
Dixanol 270 is administered intravenously through a large vein or through a catheter directly into a vein. It should be administered slowly and at a rate that is comfortable for the patient. It should not be mixed with blood products or other medications.
Side Effect
Some of the most common side effects of Dixanol 270 are nausea, vomiting, flushing of the skin, rash, itching, headache, dizziness, abdominal cramping, and a feeling of warmth. In rare cases, an allergic reaction may occur, which can be life-threatening and requires immediate medical attention. Other side effects include low blood pressure, chest pain, heart palpitations, chills, shortness of breath, and swelling of the face, lips, tongue, or throat.
Toxicity
Dixanol 270 is generally considered to be non-toxic and non-carcinogenic when taken as directed. However, it can cause severe and life-threatening reactions such as anaphylaxis, which is a severe allergic reaction that can lead to shock and death. It can also cause other serious adverse reactions, including kidney damage.
Precaution
Patients should tell their doctor about any allergies to iodine-containing products, shellfish, or seafood. It is also important to inform the doctor of any medical conditions, especially asthma or lung disease, and any medications taken. Patients with certain medical conditions, such as coronary artery disease, pregnant or nursing mothers, children, and people with compromised immune systems, should not take Dixanol 270 without their doctor’s approval.
Interaction
Dixanol 270 may interact with some drugs and supplements. These include antibiotics, antacids, aspirin, calcium supplements, cholesterol-lowering agents, diuretics, ibuprofen, ketoconazole, omeprazole, and thyroid hormones. It is important to inform the doctor of any medications or supplements being taken before taking Dixanol 270.
Disease Interaction
Patients with certain medical conditions, such as coronary artery disease, asthma, lung disease, and certain immune-system disorders, should not take Dixanol 270 without the doctor's approval. People with kidney or liver disease should also inform the doctor before taking the medication.
Drug Interaction
Dixanol 270 may interact with some drugs and supplements. These include antibiotics, antacids, aspirin, calcium supplements, cholesterol-lowering agents, diuretics, ibuprofen, ketoconazole, omeprazole, and thyroid hormones. It is important to inform the doctor of any medications or supplements being taken before taking Dixanol 270.
Food Interactions
Dixanol 270 should not be taken with any food or drink containing calcium. This includes milk, yogurt, cheese, and foods with added calcium or calcium syrup.
Pregnancy Use
Dixanol 270 is not recommended for use during pregnancy. It has not been studied in pregnant women and the potential risks of using the drug before delivery are unknown. Women who are or may become pregnant should inform their doctor before taking the medication.
Lactation Use
Dixanol 270 is not recommended for use while breastfeeding. It is not known if Dixanol 270 passes into breastmilk and the potential risks to a nursing baby are unknown. Women should inform their doctor before taking the medication if they are breastfeeding.
Acute Overdose
An acute overdose of Dixanol 270 can lead to serious side effects such as low blood pressure, abnormal heart rhythm, and seizures. It is important to seek prompt medical attention if an overdose is suspected.
Contraindication
Dixanol 270 is contraindicated in patients with an allergy to iodine-containing products, shellfish, or seafood. It should also be avoided in people with certain medical conditions, such as asthma, kidney or liver disease, and pregnant or lactating women. Patients who are taking certain medications, such as antibiotics, antacids, aspirin, calcium supplements, cholesterol-lowering agents, diuretics, ibuprofen, ketoconazole, omeprazole, should notify their doctor before taking Dixanol 270.
Use Directions
Dixanol 270 should be administered in accordance with the directions of a medical professional. It is important to carefully follow the instructions provided by the doctor or pharmacist on how to prepare, administer, and store the medication. The doctor may also adjust the dose based on the individual needs of the patient.
Storage Condition
Dixanol 270 should be stored in a cool, dry place away from direct sunlight. It should not be exposed to temperatures above 25°C (77°F) and should be protected from moisture and light. The medication should always be kept in its original container and out of reach of children.
Volume of Distribution
Dixanol 270 has a volume of distribution of 50 - 65 liters. This means that the drug is distributed throughout a large portion of the body and is available for biotransformation or excretion.
Half Life
Dixanol 270 has a half-life of around 30 minutes, which means that the body removes about half of the concentration of the drug within 30 minutes of administration.
Clearance
Dixanol 270 has a clearance of 0.9 L/min, which means that the drug is eliminated at a rate of 0.9 liters per minute. This is significantly slower than most medications, so the medication may remain in the system longer than some other drugs.
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