Dilazem
Dilazem Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Dilazem is a brand name. Its generic name is Diltiazem.
Introduction
Dilazem is a calcium channel blocker and is used to treat a number of conditions including high blood pressure, chest pain (angina) and abnormal heart rhythms. It comes in a range of formulations including tablets, capsules, and injections.
Uses for
- Treating high blood pressure
- Treating chest pain (angina)
- Treating irregular heart rhythms
Mechanism of action
Dilazem belongs to a class of drugs called calcium channel blockers. It works by blocking the flow of calcium into the cells of the heart and blood vessels. This decreases the force of contraction of the heart muscle and improves blood flow. It also affects the heart's electrical signals, which helps the heart to beat in a regular rhythm.
How long does it take to work?
Dilazem can start to work within 15 minutes of taking the drug, and its effects may last up to 24 hours. However, the effects of the drug may vary depending on the individual.
Absorption
Dilazem is absorbed quickly in the gastrointestinal tract with peak concentrations achieved within 2 to 4 hours.
Route of elimination
Dilazem is primarily eliminated through the kidneys. Approximately 60% of a dose of diltiazem is eliminated unchanged in the urine.
Dosage
Dilazem dosage can vary depending on the individual and the condition being treated. A starting dose of 30 mg 2 to 4 times a day is typically recommended for most conditions. A doctor should be consulted for specific dosing instructions.
Administration
Dilazem can be taken orally or administered intravenously. It is important to take diltiazem as prescribed by the doctor and not to increase dosage without consulting the doctor first.
Side Effects
Common side effects of diltiazem include dizziness, headache, nausea, constipation, and fatigue. Serious side effects may include difficulty breathing, chest pain, slow or irregular heartbeat, and signs of an allergic reaction.
Toxicity
Overdose symptoms may include extreme drowsiness, slow or uneven heartbeat, confusion, and fainting. If an overdose is suspected, seek immediate medical attention.
Precaution
It is important to inform the doctor of any other medications that are being taken, as diltiazem may interact with certain drugs. It is also important to tell the doctor if there is a history of liver or kidney disease, as diltiazem may not be safe in these cases.
Interaction
Dilazem may interact with certain drugs including diuretics, non-steroidal anti-inflammatory drugs (NSAIDs) and beta-blockers, as these drugs can increase the risk of low blood pressure.
Disease Interactions
Patients with a history of certain medical conditions may not be able to take diltiazem safely. These include heart disease, liver or kidney disease, and bronchial asthma. Patients with a history of heart block or sick sinus syndrome may need to be closely monitored for signs of irregular heartbeat or low blood pressure.
Drug Interactions
Dilazem may interact with many different drugs, including certain antibiotics, antifungal medications, calcium channel blockers, and antacids. It is important to tell the doctor about any other medications that are being taken in order to avoid any potential drug interactions.
Food Interactions
Dilazem should be taken with food or milk to reduce the chance of stomach upset. Grapefruit and grapefruit juice should be avoided as this may increase the blood levels of diltiazem and increase the risk of side effects.
Pregnancy Use
Dilazem is not recommended for use in pregnant women as it may harm the unborn child. It is important to talk to the doctor before using this medication if there is a chance of pregnancy.
Lactation Use
Dilazem should not be used while breastfeeding, as there is a risk of it passing into breast milk and affecting the baby.
Acute Overdose
Acute overdose of diltiazem can cause severe hypotension, bradycardia, heart block, and conduction disturbances. Treatment may involve the use of vasopressors to raise a patient's blood pressure or using a pacemaker to normalize the patient's heart rate.
Contraindication
Dilazem should not be used in patients with a known hypersensitivity or allergy to the drug, as this can cause severe reactions. It should also be avoided in patients with certain medical conditions, including sick sinus syndrome, severe bradycardia, AST/ALT levels greater than three times the upper limit of normal, and severe liver dysfunction.
Use Direction
Dilazem should be taken as prescribed by the doctor. It is important to follow the instructions on the prescription label and to take the medication at the same times each day. Additionally, it is important to take the medication with food or milk in order to reduce the risk of stomach upset.
Storage Conditions
Dilazem should be stored at room temperature in a dry and dark place, away from direct sunlight and heat. It should be kept away from children and pets.
Volume of Distribution
The volume of distribution of diltiazem is 20.4 L/kg.
Half Life
The half life of diltiazem is 3 to 7 hours.
Clearance
The clearance of diltiazem is 0.18 L/h/kg.
Here you find in details version of Dilazem
Some Frequently Asked Questions About Dilazem
1. What is diltiazem?
Dilazem is a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels. It is used to treat high blood pressure, angina, and certain heart rhythm disorders.
2. How long does it take for diltiazem to start working?
It usually takes 1-2 weeks for diltiazem to start working and reach its full effect.
3. How should I take diltiazem?
Dilazem should be taken exactly as prescribed by your doctor. It is important to follow your doctor's instructions carefully and to take the medication at the same time each day.
4. Is diltiazem used to treat other conditions?
Dilazem is also used to treat certain types of abnormal heartbeats (such as atrial fibrillation) and to prevent chest pain.
5. Does diltiazem have any side effects?
Some common side effects may include dizziness, constipation, headache, swelling in the legs and feet, and an increased risk of infection.
6. Is diltiazem safe to take while pregnant?
The safety of diltiazem during pregnancy has not been established. It is important to talk to your doctor about the potential risks of taking diltiazem during pregnancy.
7. What should I tell my doctor before taking diltiazem?
Tell your doctor about any other medications you are taking, other medical conditions you may have, allergies, and any other important health information. Also tell your doctor if you are pregnant or planning to become pregnant.
8. What should I avoid while taking diltiazem?
Do not drink alcoholic beverages while taking diltiazem. Also, avoid activities that could be dangerous if you are dizzy or drowsy, such as driving. Also, do not take any other medications without your doctor's approval.
9. What drugs interact with diltiazem?
Some drugs that may interact with diltiazem include certain antibiotics, antifungal medications, antihypertensive medications, and certain heart medications (such as digoxin). Talk to your doctor about all drugs you are taking.
10. What should I do if I miss a dose of diltiazem?
If you miss a dose of diltiazem, take it as soon as you remember. However, if it is close to your next scheduled dose, skip the missed dose and take the next one as directed.
11. Is diltiazem an over-the-counter drug?
No, diltiazem is not available over-the-counter. You must have a prescription from your doctor.
12. How long should I stay on diltiazem?
The length of time you are on diltiazem will depend on your individual health needs. Talk to your doctor about how long you need to take the medication.
13. Can I take diltiazem with other medications?
Yes, you can take diltiazem with other medications. However, it is important to make sure your doctor is aware of all medications and supplements you are taking as there can be potential drug interactions.
14. Does diltiazem lower blood pressure?
Yes, diltiazem can lower blood pressure. It works by relaxing the muscles of your heart and blood vessels, which helps to lower blood pressure.
15. Does diltiazem help with chest pain?
Yes, diltiazem is used to help treat and prevent chest pain (angina). It helps to relax the muscles of your heart and blood vessels, which helps to improve blood flow and reduce chest pain.
16. Can diltiazem cause an irregular heartbeat?
Yes, diltiazem can cause an irregular heartbeat in some people. It is important to alert your doctor if you experience any changes in your heart rate or rhythm while taking diltiazem.
17. Can diltiazem cause weight gain?
Weight gain has been reported as a possible side effect of diltiazem. If you experience any weight gain while taking diltiazem, it is important to consult with your doctor.
18. Does diltiazem interact with grapefruit or grapefruit juice?
Yes, grapefruit and grapefruit juice can interact with diltiazem and increase the risk of side effects. It is important to check with your doctor or pharmacist before consuming grapefruit or grapefruit juice while taking diltiazem.
19. Is there a generic version of diltiazem?
Yes, a generic version of diltiazem is available in most pharmacies. The generic name for diltiazem is diltiazem hydrochloride.
20. Does diltiazem come in a topical (skin) form?
No, diltiazem is not available in a topical (skin) form. It is available as an oral medication or an intravenous injection.
21. Can I stop taking diltiazem abruptly?
No, it is important to consult with your doctor before stopping diltiazem. Your dose of diltiazem may need to be gradually decreased over time to reduce the risk of side effects.
22. Does diltiazem cause constipation?
Yes, constipation is a possible side effect of diltiazem. If you experience constipation while taking diltiazem, it is important to talk to your doctor.
23. Can I drink alcohol while taking diltiazem?
No, it is not recommended to drink alcohol while taking diltiazem as it can increase the risk of side effects. Talk to your doctor before drinking alcohol.
24. Does diltiazem lower cholesterol?
Yes, diltiazem can lower cholesterol. It may also help to reduce the risk of certain heart conditions such as atherosclerosis (hardening of the arteries).
25. Is diltiazem safe for an elderly person?
Yes, diltiazem is safe for elderly people. However, they should be monitored closely as they may be more sensitive to the effects of the medication.
26. Will diltiazem interact with my other medications?
Yes, it is important to check with your doctor or pharmacist before taking any other medication with diltiazem as there may be potential drug interactions.
27. Is diltiazem safe to take long-term?
Yes, diltiazem is generally considered safe to take long-term. However, it is important to consult with your doctor before using diltiazem for a prolonged period of time.
28. Will diltiazem affect my ability to drive or operate machinery?
Yes, diltiazem may cause drowsiness or dizziness. It is important to avoid driving or operating machinery until you know how diltiazem affects you.
29. Does diltiazem interact with other herbal supplements?
Yes, certain herbal supplements may interact with diltiazem. It is important to check with your doctor or pharmacist before taking any herbal supplements with diltiazem.
30. What are the common side effects of diltiazem?
The most common side effects of diltiazem are dizziness, constipation, headache, swelling in the legs and feet, and an increased risk of infection. Talk to your doctor if you experience any of these side effects.