Dianide
Dianide Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Dianide is a brand name. Its generic name is Nitazoxanide.
Introduction
Dianide is an anthelmintic and anti-protozoal drug used to treat various parasitic infections such as giardiasis, cryptosporidiosis, and trichomoniasis, as well as helminthic infections like ascariasis and hookworm. It is available in oral and intravenous solutions.Uses
Dianide is used to treat the following infections: Giardia lamblia, Cryptosporidium, Trichomonas vaginalis, Ascariasis, Enterobius vermicularis, Ancylostoma duodenale and Necator americanus.Mechanism of Action
Dianide works by inhibiting the cytopathic effect of certain protozoa and helminths. It may works by interfering with DNA and RNA synthesis and by inhibiting the development of the parasites.How Long Does it take to Work?
The time it takes for nitazoxanide to take effect varies and depends on the type of infection being treated. Generally, it begins to work within hours or days after ingestion, however, in order for full effectiveness, it may be necessary to continue taking nitazoxanide for several weeks or months.Absorption
Dianide is absorbed quickly and completely when taken orally. The peak plasma concentration reaches within one hour of dosing.Route of Elimination
Dianide is eliminated mainly through the feces. It is not known to be excreted in urine.Dosage
Dianide is available in tablet form in the following dosages:- Adult dose: 500 mg twice daily for three days.
- Children 2-11 years: one 11-30 mg/kg/day in two divided doses (maximum 500 mg/day) three days duration or two divided doses (maximum 12 mg/kg/day) for five days.
- Children 1-2 years: 11 mg/kg/day in two divided doses (maximum 500 mg/day) three days duration or two divided doses (maximum 12 mg/kg/day) for five days.
Administration
Dianide should be taken orally, with food or milk to reduce gastrointestinal side effects. It should be swallowed whole with a glass of water without crushing, splitting or chewing the tablet.Side Effects
Common side effects of Dianide include: nausea, vomiting, abdominal pain, headache, dizziness, and diarrhea. Serious side effects are rare, but may include an increased risk of developing an infection, liver toxicity, or allergic reactions.Toxicity
Dianide is generally considered to be safe at recommended doses. An acute overdose of nitazoxanide can lead to vomiting, diarrhea, tremors, increased heart rate, and confusion.Precautions
Patients should inform their healthcare provider if they have a history of liver or kidney disease before taking Dianide. In addition, it is important to drink plenty of fluids while taking this medication to reduce the risk of dehydration.Interactions
Dianide may interact with other medications, including antibiotics, antifungals, and anticonvulsants. It should not be taken with the anticonvulsants phenobarbital and primidone. Patients should inform their healthcare provider of all medications they are taking before starting Dianide.Disease Interaction
Patients with a history of liver or kidney disease should not take Dianide. In addition, this medication should be used cautiously in patients with decreased kidney function, as it is excreted mainly by the kidneys.Drug Interaction
Drugs that may interact with Dianide include antibiotics, antifungals, anticonvulsants, and antidiabetics. It should not be taken with the anticonvulsants phenobarbital and primidone. Patients should inform their doctor of all medications they are taking before starting Dianide.Food Interactions
Dianide can be taken with or without food. Taking the medication with food may reduce gastrointestinal side effects.Pregnancy Use
Dianide should not be used during pregnancy as it may cause harm to the unborn baby.Lactation Use
Dianide is not known to pass into breast milk and can be used by breastfeeding mothers. However, caution should be exercised as there have not been sufficient studies to assess the safety of this drug in breastfeeding women.Acute Overdose
An acute overdose of Dianide can result in vomiting, diarrhea, tremors, increased heart rate, and confusion. Treatment of an overdose usually involves supportive care, such as intravenous fluids to prevent dehydration and monitor vital signs.Contraindication
Dianide should not be used in patients with a known hypersensitivity to the drug. It should also not be used in pregnant or breastfeeding women, or in patients with a history of liver or kidney disease.Use Direction
Dianide should be taken orally, with food or milk to reduce gastrointestinal side effects. It should be swallowed whole with a glass of water without crushing, splitting or chewing the tablet.Storage Condition
Dianide should be stored at room temperature away from light and moisture. Do not store in the bathroom. Keep out of the reach of children.Volume of Distribution
The volume of distribution of nitazoxanide has not been determined in humans.Half Life
The elimination half-life of nitazoxanide is 8-14 hours.Clearance
The clearance of nitazoxanide is 4.6 ± 2.5mL/min/kg.Here you find in details version of Dianide
Some Frequently Asked Questions About Dianide
What is Dianide?
Dianide is an antiparasitic medication used to treat infections caused by parasites, such as Giardia, Cryptosporidium, and Entamoeba species.
What is Dianide used to treat?
Dianide is used to treat infections caused by parasites, such as Giardia, Cryptosporidium, and Entamoeba species. It can also be used to treat diarrhea caused by these parasites.
How does Dianide work?
Dianide works by blocking the energy production process of parasites, which inhibits their growth and reproduction. This ultimately leads to the death of the parasites.
Are there any side effects associated with Dianide?
The most common side effects of Dianide are nausea, diarrhea, stomach pain, and vomiting. If these side effects are severe or do not go away, talk to your doctor about other treatment options.
Does Dianide interact with any other drugs?
Dianide may interact with certain antibiotics, medications for diabetes, warfarin, and other medications. It is important to tell your doctor about all prescription, over-the-counter, and herbal medications that you are taking before using Dianide.
Who should not take Dianide?
You should not take Dianide if you are pregnant, breastfeeding, have severe liver or kidney disease, or are allergic to Dianide or any of its ingredients. Talk to your doctor before starting any new medications.
What should I do if I miss a dose of Dianide?
If you miss a dose of Dianide, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue on your regular dosing schedule. Do not double your dose to make up for the missed dose.
How long does it take for Dianide to work?
The time it takes for Dianide to work varies depending on the type of infection and the dosage. Most infections improve after 1 to 3 days of treatment, but it may take up to 10 days for some infections.
What should I do if I experience an allergic reaction to Dianide?
If you experience an allergic reaction to Dianide, such as hives, difficulty breathing, or swelling, stop taking the medication and seek emergency medical attention.
Is Dianide safe for children?
Yes, Dianide is safe for children. It is important to follow the dosage instructions as directed by your doctor. Do not give your child a double dose if they miss one.
Will I need to take a second dose of Dianide if my infection does not improve?
In most cases, a single dose of Dianide is enough to treat an infection. However, if your infection does not improve after one dose, your doctor may prescribe a second dose of the medication.
Is Dianide approved by the FDA?
Yes, Dianide is approved by the US Food and Drug Administration (FDA). It is available in the US as a prescription medication.
Can I take Dianide while breastfeeding?
No, you should not take Dianide while breastfeeding. It is unknown if the medication passes into breast milk, so it is best to avoid taking it while breastfeeding.
Can Dianide be used to treat other conditions?
No, Dianide is only approved to treat infections caused by parasites. It should not be used to treat any other condition.
Can Dianide be used to treat traveler's diarrhea?
Yes, Dianide can used to treat traveler's diarrhea caused by parasites. Talk to your doctor about the best way to treat your condition.
Is Dianide safe to take during pregnancy?
No, Dianide should not be taken during pregnancy. The safety of this medication during pregnancy has not been established. Talk to your doctor about other treatment options.
How should Dianide be stored?
Dianide should be stored at room temperature away from light and moisture. Keep the medication in the original container and do not store it in the bathroom or other damp areas.
How long should Dianide be taken?
The length of time Dianide is taken depends on the type and severity of infection. Your doctor will determine the right course of treatment for you.
Are there any other medications I can take if Dianide doesn't work?
If Dianide does not work, there are other antiparasitic medications, such as metronidazole, that can be used to treat parasitic infections. Talk to your doctor about the best treatment option for you.
What is the most common dosage of Dianide?
The most common dosage of Dianide is 500mg taken twice daily for 3 days. However, the exact dosage and length of treatment may differ depending on the type and severity of the infection.
Can Dianide be taken with food?
Yes, Dianide can be taken with or without food. If the medication causes an upset stomach, try taking it with meals or snacks.
Is Dianide available over-the-counter?
No, Dianide is not available over-the-counter. It is only available as a prescription medication.
Can Dianide be used to treat viral infections?
No, Dianide is not effective against viral infections and should not be used to treat them.
Are there any other uses for Dianide?
No, Dianide is only approved to treat parasitic infections. It should not be used to treat any other conditions.
What should I do if I experience severe stomach pain while taking Dianide?
If you experience severe stomach pain while taking Dianide, stop taking the medication and call your doctor right away. Severe stomach pain could be a sign of a serious reaction to the medication.
Is Dianide covered by insurance?
This depends on your insurance provider. Check with your insurance company to see if Dianide is covered under your plan.
Is it safe to take Dianide for a long time?
No, Dianide is not meant to be taken for a long period of time and should only be taken for the duration of your infection. Talk to your doctor about any concerns you have about long-term use of Dianide.
Does Dianide cause drowsiness?
No, Dianide does not typically cause drowsiness. However, it is important to talk to your doctor about any side effects you experience while taking this medication.
Can Dianide cause a rash?
Yes, Dianide can cause a rash in some people. If you experience a rash while taking this medication, stop taking Dianide and talk to your doctor right away.
What safety measures should be taken while taking Dianide?
It is important to read and follow the instructions in the medication guide before taking Dianide. It is also important to drink plenty of fluids to prevent dehydration and to tell your doctor if you have any pre-existing medical conditions.
Is Dianide safe to take while taking other medications?
Yes, Dianide is generally safe to take with other medications. However, it is always important to talk to your doctor about all medications you are taking before starting Dianide.
Can Dianide be taken with alcohol?
No, Dianide should not be taken with alcohol. Drinking alcohol can decrease the effectiveness of the medication and may increase the risk of serious side effects.
Can I donate blood after taking Dianide?
Yes, you can donate blood after taking Dianide. However, make sure to inform the person collecting the blood of the medications that you are taking.
What are the possible drug interactions with Dianide?
Dianide can interact with certain antibiotics, medications for diabetes, warfarin, and other medications. It is important to tell your doctor or pharmacist about all other medications you are taking before starting Dianide.
Does Dianide have any long-term side effects?
There are no known long-term side effects associated with Dianide. However, if you experience any persistent or unusual side effects, talk to your doctor right away.
Will I still need to take Dianide if I have a fever?
If you have a fever and are taking Dianide for an infection caused by parasites, it is important to finish the full course of the medication as prescribed by your doctor. Fever is a sign that your body is fighting the infection and the medication can help speed up the process.
Is Dianide available as a generic medication?
No, Dianide is not currently available as a generic medication. However, generic versions of the drug may become available in the future.
Can I take Dianide with ibuprofen?
Yes, you can take Dianide with ibuprofen. However, it is important to talk to your doctor or pharmacist before taking any other medications while taking Dianide.
Should I take Dianide if I am experiencing nausea?
If you are experiencing nausea and you are taking Dianide for a parasite infection, it is important to finish the full course of the medication as prescribed by your doctor. Taking the medication with food may help reduce nausea.
Can Dianide cause an increased heart rate?
Yes, Dianide can cause an increased heart rate. If you experience an unusually fast or erratic heartbeat while taking this medication, talk to your doctor right away.
What should I do if I experience vomiting or constipation while taking Dianide?
If you experience vomiting or constipation while taking Dianide, talk to your doctor right away. These side effects may require changes to your diet or the use of other medications.
Can I take Dianide if I have high blood pressure?
Yes, you can take Dianide if you have high blood pressure. However, it is important to monitor your blood pressure closely while taking this medication.