Diamide

Diamide Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Diamide is a brand name. Its generic name is Gliclazide.

Introduction

Diamide (also known as glyburide) is an oral anti-diabetic medication used to treat type 2 diabetes. It works by encouraging the release of insulin and lowering the blood sugar levels. It may also be used for other conditions as determined by your doctor.

Uses for

Diamide is used to treat type 2 diabetes by helping to lower the blood sugar levels. It is usually prescribed after other diabetes medications have been tried without successful treatment of symptom.

Mechanism of Action

Diamide works to treat type 2 diabetes by increasing the effect of insulin, which signals the body to lower the blood sugar level. It can help control glucose levels by increasing the release of insulin and reducing the amount of sugar produced by the liver.

How Long Does it Take to Work?

The duration of action of gliclazide is usually 6 to 12 hours, however it can take up to two weeks for it to reach its maximal effect.

Absorption

Diamide is rapidly absorbed in the gastrointestinal tract. It is mainly absorbed in the small intestine, with some absorption in the stomach.

Route of Elimination

Diamide is eliminated mainly through the kidneys. Approximately 70-90% of it is excreted unchanged in the urine.

Dosage

For adults, the recommended starting dose is 30-60mg once daily before the morning meal. The dose can be increased by 30-60mg every 1-2 weeks until the desired blood sugar levels have been achieved. It is important to take the same amount and time of dose each day.

Administration

Diamide should be taken as directed by your doctor, usually once daily before a meal. It should be swallowed whole with a glass of water.

Side Effect

Diamide can cause side effects such as nausea, vomiting, dizziness, headache, blurred vision, paleness, stomach pain, loss of appetite, diarrhea, lightheadedness, fatigue, and constipation.

Toxicity

Diamide is considered to be a low toxicity medication. In case of overdose, symptomatic and supportive treatment should be provided.

Precautions

Diamide can interact with other medications and increase the risk of side effects. It is important to tell your doctor about all the medications that you are taking before taking gliclazide.

Interaction

Diamide can interact with other medications and increase the risk of side effects. It is important to tell your doctor about all the medications that you are taking before taking gliclazide.

Disease Interaction

Diamide may interact with certain diseases and conditions such as liver, kidney, or heart disease; thyroid disorders; and asthma. It is important to tell your doctor about all of your medical conditions before taking gliclazide.

Drug Interactions

Diamide may interact with other medications and increase the risk of side effects. It is important to tell your doctor about all the medications that you are taking before taking gliclazide.

Food Interactions

Diamide can interact with certain foods and beverages and increase the risk of side effects. It is important to avoid foods high in sugar and fat while taking gliclazide.

Pregnancy Use

Diamide should not be used during pregnancy. Consult your doctor about the potential risks and benefits of taking gliclazide during pregnancy.

Lactation Use

It is unknown whether gliclazide is excreted in breast milk. It is recommended to avoid taking gliclazide while breastfeeding.

Acute Overdose

In case of an acute overdose of gliclazide, symptomatic and supportive treatment should be provided.

Contraindication

Diamide should not be used in patients with diabetic ketoacidosis, type 1 diabetes, type 3 diabetes, and in those allergic to it.

Use Direction

Diamide should be taken exactly as prescribed by your doctor. Do not increase or decrease the dose, or take the medication for a longer period of time than prescribed.

Storage Conditions

Diamide should be stored at room temperature, away from direct sunlight, heat and moisture. It should be kept out of the reach of children and pets.

Volume of Distribution

The volume of distribution of gliclazide is approximately 20-50 L/kg.

Half life

The elimination half-life of gliclazide is 1.5-4.5 hours.

Clearance

The clearance of gliclazide in adults is 0.15-0.3 ml/min/kg.

Here you find in details version of Diamide

Some Frequently Asked Questions About Diamide

What is Diamide?

Diamide is a medication which belongs to the group of medicines called sulfonylureas. It is used to control blood glucose levels in people with type 2 diabetes.

How does Diamide work?

Diamide works by increasing the amount of insulin that is released by the pancreas which helps to control blood glucose levels in people with Type 2 diabetes.

What are the uses of Diamide?

Diamide is used to control blood glucose levels in people with Type 2 diabetes.

What are the side effects of Diamide?

Diamide may cause some side effects, including headache, nausea, weight gain, tiredness, and some skin rashes.

Does Diamide cause hypoglycemia?

Yes, Diamide can cause hypoglycemia, which is a condition where the blood glucose levels become too low. Symptoms of hypoglycemia include sweating, hunger, shakiness, dizziness, and confusion.

How should Diamide be taken?

Diamide should be taken orally usually once or twice a day as directed by your doctor.

How long does it take for Diamide to work?

Diamide usually starts to work within 1-2 hours after it is taken.

Does Diamide need to be taken with food?

No, Diamide does not need to be taken with food. It can be taken before, with, or after meals.

What is the recommended dose of Diamide?

The recommended dose of Diamide depends on the individual and the type of diabetes. It is important to follow the instructions of your doctor or pharmacist.

What should I do if I forget to take Diamide?

If you forget to take Diamide, take it as soon as you remember. If it is close to the time of your next dose, skip the missed dose. Do not double your dose.

Should I avoid alcohol while taking Diamide?

Yes, it is recommended to avoid alcohol while taking Diamide as it can increase the risk of adverse effects such as low blood sugar.

Can Diamide be taken while pregnant or breastfeeding?

Diamide should not be taken while pregnant or breastfeeding. Speak to your doctor before taking any medication while pregnant or breastfeeding.

What foods should I avoid while taking Diamide?

It is important to follow a healthy and balanced diet while taking Diamide. Avoid foods high in sugar, fat, and cholesterol.

Is Diamide available as a generic medication?

Yes, Diamide is available as a generic medication.

What other medications should not be taken with Diamide?

Certain medications can interact with Diamide and should not be taken together. This includes ACE inhibitors, diuretics, sulfonamides, cimetidine, and other sulfonylureas.

Can I take Diamide with metformin?

Yes, Diamide can be taken with metformin. It is important to take both medications as prescribed by your doctor.

Are there any alternatives to Diamide?

Yes, there are other medications available to control blood glucose levels. Speak to your doctor or pharmacist about other alternatives.

Can Diamide be used to treat type 1 diabetes?

No, Diamide is not suitable for use in people with type 1 diabetes.

Does Diamide cause weight gain?

Diamide can cause weight gain in some cases. It is important to follow a healthy and balanced diet and to exercise regularly.

What should I do if I experience side effects while taking Diamide?

If you experience side effects while taking Diamide, speak to your doctor or pharmacist. They may be able to suggest a change in dosage or medication to help alleviate the side effects.

Can diabetic ketoacidosis occur while taking Diamide?

Yes, diabetic ketoacidosis can occur while taking Diamide. Symptoms include dry mouth, thirst, fatigue, fruity odor on breath, and rapid breathing.

How should Diamide be stored?

Diamide should be stored at room temperature away from direct sunlight and heat. Do not keep Diamide in the refrigerator or freezer.

Can I overdose on Diamide?

Yes, it is possible to overdose on Diamide. If you or someone you know has taken an overdose, call your local poison control center or emergency services immediately.

Can I donate blood while taking Diamide?

No, it is recommended that you do not donate blood while taking Diamide.

Can I take Diamide if I have kidney disease?

It is recommended that you speak to your doctor before taking Diamide if you have kidney disease. Your doctor may recommend a different medication.

Is Diamide a blood thinner?

No, Diamide is not a blood thinner. It is used to control blood glucose levels in people with Type 2 diabetes.

Can Diamide be used to treat Type 1 diabetes?

No, Diamide is not suitable for use in people with Type 1 diabetes.

Can Diamide cause low blood pressure?

Yes, Diamide can cause low blood pressure, which can cause dizziness, lightheadedness, and fainting.

Can I take Diamide while taking other medications?

It is important to let your doctor know about all medications that you are taking before taking Diamide. Certain medications can interact with Diamide.

Does Diamide raise cholesterol levels?

Yes, Diamide can raise cholesterol levels. It is important to follow a healthy and balanced diet to help maintain healthy cholesterol levels.

Is Diamide a steroid?

No, Diamide is not a steroid. It is used to control blood glucose levels in people with Type 2 diabetes.

Does Diamide cause diarrhea?

Yes, Diamide can cause diarrhea. If you experience diarrhea while taking Diamide, speak to your doctor or pharmacist.

Can I take Diamide with ibuprofen?

It is recommended that you do not take Diamide with ibuprofen as it may increase the risk of adverse effects. Speak to your doctor before taking any medications together.

Can I take Diamide with muscle relaxers?

It is recommended that you do not take Diamide with muscle relaxers as it may increase the risk of adverse effects. Speak to your doctor before taking any medications together.

What should I do if I miss a dose of Diamide?

If you miss a dose of Diamide, take it as soon as you remember. If it is close to the time of your next dose, skip the missed dose. Do not double your dose.

Can I take Diamide while breastfeeding?

No, it is recommended that you do not take Diamide while breastfeeding. Speak to your doctor before taking any medications while breastfeeding.

Can I take Diamide while pregnant?

No, it is recommended that you do not take Diamide while pregnant. Speak to your doctor before taking any medications while pregnant.

Can Diamide cause headaches?

Yes, Diamide can cause headaches in some people. If you experience headaches while taking Diamide, speak to your doctor or pharmacist.

Can I take Diamide with other diabetes medications?

Yes, Diamide can be taken with other diabetes medications. It is important to follow the instructions of your doctor or pharmacist.

What should I do if I experience low blood sugar while taking Diamide?

If you experience low blood sugar while taking Diamide, it is important to eat or drink something sugary, such as fruit juice, honey, candy, or a glucose tablet. It is also important to speak to your doctor or pharmacist.

Are there any foods that I should avoid while taking Diamide?

It is important to follow a healthy and balanced diet while taking Diamide. Avoid foods high in sugar, fat, and cholesterol.

How long can I take Diamide for?

The length of time that you take Diamide for depends on the individual and the type of diabetes. It is important to follow the instructions of your doctor or pharmacist.

Is Diamide a controlled substance?

No, Diamide is not a controlled substance.