Dezide

Dezide Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Dezide is a brand name. Its generic name is Hydrochlorothiazide + Triamterene.

Introduction

Hydrochlorothiazide (HCTZ) and Triamterene is a combination of two drugs, used for the treatment of fluid retention (edema) associated with congestive heart failure, cirrhosis of the liver and nephrotic syndrome. It is also used to treat hypertension (high blood pressure).

Uses

Hydrochlorothiazide (HCTZ) and Triamterene is used to reduce edema related with congestive heart failure, cirrhosis of the liver, and nephrotic syndrome. It can also be used to control hypertension (high blood pressure).

Mechanism of action

Hydrochlorothiazide (HCTZ) is a thiazide diuretic which acts on the distal tubules by inducing diuresis, decreasing blood volume and reducing blood pressure. Triamterene, another agent in the combination, acts by blocking sodium reabsorption in the distal convoluted tubules, thereby increasing diuresis and decreasing plasma volume.

How long does it take to work?

The effects of the combination therapy can be seen in 24 hours.

Absorption

Hydrochlorothiazide (HCTZ) is rapidly and completely absorbed, while Triamterene is slowly and incompletely absorbed from the gastrointestinal tract.

Route of elimination

Hydrochlorothiazide (HCTZ) and Triamterene are eliminated in the urine.

Dosage

The recommended dose of Hydrochlorothiazide (HCTZ) and Triamterene is 25mg-75mg once daily, administered orally with or without food.

Administration

Hydrochlorothiazide (HCTZ) and Triamterene should be taken orally with or without food. It should be taken exactly as prescribed by your doctor. Do not alter the dosage without talking to your doctor first.

Side effects

Common side effects of Hydrochlorothiazide (HCTZ) and Triamterene include low blood pressure, nausea, vomiting, diarrhea,loss of appetite, abdominal cramps, blurred vision, headache, dizziness, skin rash, and decreased sexual ability.

Toxicity

The toxicity of Hydrochlorothiazide (HCTZ) and Triamterene is low. It is unlikely to cause significant toxicity.

Precautions

Patients with hyponatremia (low sodium levels in the blood) should not take Hydrochlorothiazide (HCTZ) and Triamterene. People who are allergic to sulfonamide drugs or have any kidney, liver, or heart disease should not take this medication. This medication should not be used in pregnant women or women who are breastfeeding.

Interactions

This medication can interact with other medications. It is important to tell your doctor about all medications you are taking, including non-prescription, vitamins, and herbal remedies.

Drug Interactions

Hydrochlorothiazide (HCTZ) and Triamterene may interact with other drugs, such as diuretics, nonsteroidal anti-inflammatory drugs, lithium, and ACE inhibitors.

Food Interactions

Hydrochlorothiazide (HCTZ) and Triamterene may interact with certain foods. It is important to avoid foods high in sodium such as processed meats, canned soups, and frozen dinners.

Pregnancy Use

Hydrochlorothiazide (HCTZ) and Triamterene should not be used in pregnant women.

Lactation Use

Hydrochlorothiazide (HCTZ) and Triamterene should not be used while breastfeeding.

Acute Overdose

If an overdose of Hydrochlorothiazide (HCTZ) and Triamterene is suspected, seek medical attention immediately.

Contraindication

Hydrochlorothiazide (HCTZ) and Triamterene is contraindicated in patients with an allergy to sulfonamides.

Use Directions

Follow your doctor’s directions carefully for taking Hydrochlorothiazide (HCTZ) and Triamterene. Do not take more or less of the medication than prescribed.

Storage Conditions

Store Hydrochlorothiazide (HCTZ) and Triamterene in a tightly closed container away from heat, moisture, and direct light.

Volume of Distribution

Hydrochlorothiazide (HCTZ) and Triamterene has a volume of distribution of approximately 3 liters/kg.

Half-Life

The half-life of Hydrochlorothiazide (HCTZ) and Triamterene is 2 to 4 hours.

Clearance

Hydrochlorothiazide (HCTZ) and Triamterene is eliminated primarily by the kidney with an associated clearance of 18-24 mL/min.

Here you find in details version of Dezide

Some Frequently Asked Questions About Dezide

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What is Dezide?

Dezide is a combination medication composed of hydrochlorothiazide (a water pill) and Triamterene (a potassium-sparing diuretic). It works by reducing the amount of water and salt in the body, thus helping with high blood pressure.

Who should not take Dezide?

People with an allergy to hydrochlorothiazide, triamterene or other sulfonamide drugs (Jantoven, Bactrim, Gantanol, etc.) should not take Dezide. People with kidney or liver disease, gout, diabetes, lupus, or an electrolyte imbalance should also not take this medication.

How does Dezide work?

Hydrochlorothiazide and Triamterene both work as diuretics. Hydrochlorothiazide helps to increase the amount of salt and water that is eliminated from the body. Triamterene helps to prevent the body from losing too much potassium while the salt and water are being eliminated.

What are the side effects of Dezide?

Some common side effects include an increase in urination, dizziness, drowsiness, headache, fatigue, constipation, nausea, vomiting, dry mouth, and muscle cramps. Serious side effects include signs of an allergic reaction and electrolyte abnormalities.

What is the dosage of Dezide?

The dosage is based on your medical condition, response to treatment, other medications you are taking, and other factors. It is important to follow your doctor's instructions carefully. The standard dose ranges from one tablet to four tablets a day.

How long does it take Dezide to work?

It may take several days for the full effects of Dezide to be seen. Your doctor may need to adjust your dose or switch you to a different medication if your blood pressure doesn't improve after a few weeks.

Are there any drug interactions with Dezide?

Yes, Dezide can interact with other medications. So, it is important to tell your doctor about any other medications you are taking, including over-the-counter medications and supplements. Certain medications, such as antacids and anti-seizure medications, can interfere with Dezide's ability to work properly.

Does Dezide cause weight gain?

No, Dezide does not cause weight gain. In fact, because of its diuretic action, this medication may cause some people to lose weight due to an increased amount of water and salt being eliminated from the body.

Can I drink alcohol while taking Dezide?

It is not recommended to drink alcohol while taking Dezide because alcohol can cause your blood pressure to drop too low. Low blood pressure can cause dizziness, lightheadedness, or fainting. Talk to your doctor if you must consume alcohol while taking Dezide.

Can I take Dezide if I am pregnant?

It is not recommended to take Dezide if you are pregnant or planning to become pregnant. However, if you are pregnant and must take this medication, talk to your doctor about the potential risks and benefits of treatment.

Can Dezide be used to treat other medical conditions?

Dezide is used to treat high blood pressure. It is not approved to treat any other medical conditions. Only use this medication as directed by your doctor.

What foods should I avoid while taking Dezide?

It is important to avoid foods that are high in sodium or salt while taking Dezide as these can increase your blood pressure. Avoid processed meats, canned soups, pickled foods, and salty snacks. Be sure to talk to your doctor about any dietary restrictions or changes you should make while taking this medication.

Does Dezide cause diarrhea?

Diarrhea is a rare side effect of taking Dezide. If you experience diarrhea, contact your doctor right away to determine if you need to adjust your dose, change medications, or take additional measures.

What is the best time of day to take Dezide?

Your doctor will give you specific instructions on when to take Dezide. Generally, it should be taken around the same time each day, either in the morning or the evening. Taking it at the same time each day helps to maintain an even concentration of the medication in your blood.