Dersa

Dersa Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Dersa is a brand name. Its generic name is Silver Sulfadiazine.

Dersa

Silver sulfadiazine, also known as SSD or silvadene, is an antibacterial topical cream used to treat wounds such as burns, skin ulcers, and post-surgical wounds. It is composed of silver and sulfadiazine. Silver sulfadiazine has been used for over 50 years and is widely used to treat infected wounds as it is effective against a broad spectrum of bacteria, including Gram-positive and Gram-negative, as well as fungi.

Uses For Dersa

Silver sulfadiazine is primarily used for the prevention and treatment of infection in wounds such as burns, skin ulcers, and post-surgical wounds. It is also used to treat and prevent secondary infections in trauma-related skin damage.

Mechanism of Action

Silver sulfadiazine works by blocking bacterial proteins in the skin, inhibiting the growth of bacteria. Silver ions destroy essential structures such as cell walls and DNA within the bacteria, causing their death. Silver sulfadiazine also acts as an antifungal agent due to its fungistatic properties.

How Long Does It Take To Work?

Silver sulfadiazine is a fast-acting topical cream, with effects seen within a few hours of application. It can be used to heal and prevent infection in wounds very quickly, and typically does not require any prescription.

Absorption

Silver sulfadiazine is a topical cream, so it is not absorbed through the skin. It only works when applied directly to the wound. It is not recommended to be taken internally as it can be toxic.

Route of Elimination

Silver sulfadiazine is excreted in sweat, urine, and feces in humans. It is not metabolized in the body, rather it is eliminated as it is taken in.

Dosage

The recommended dose of silver sulfadiazine will vary depending on the patient and the severity of the wound. It is usually administered topically in a cream form two to four times a day. In general, the frequency of application and the amount of silver sulfadiazine is determined by the wound size. For adults, apply a thin layer of 1% cream over the entire wound area two to three times daily and cover with an occlusive bandage or dressing. For children, apply one to two times daily as directed by their doctor.

Administration

Silver sulfadiazine should be applied topically, directly to the wound. The cream should be applied thinly over the affected area two to three times daily. An occlusive, breathable dressing, such as gauze or a transparent film dressing, should be used to cover the wound. This helps to keep the silver sulfadiazine cream in the wound area and away from healthy skin.

Side Effect

The most common side effects of silver sulfadiazine are mild and transient stinging or burning where applied and dryness. Other reported side effects include rash, hives, itching, redness, or shortness of breath. If these symptoms persist or worsen, contact a doctor.

Toxicity

Silver sulfadiazine is safe when used as directed, however it can be toxic when taken internally. Overdoses of silver sulfadiazine may cause vomiting, headache, nausea, and abdominal pain, as well as severe kidney and liver damage.

Precautions

Before using silver sulfadiazine, it is important to inform your doctor if you have ever had any adverse reactions to sulfonamides or silver-based medications. The cream should not be used on patients who are hypersensitive or allergic to sulfonamides or silver compounds. Do not use silver sulfadiazine on open wounds or on areas of the skin which are inflamed, infected, or irritated. Silver sulfadiazine cream should be applied in a thin layer and covered with an occlusive dressing or bandage. Do not apply the cream near the eyes or mouth.

Interaction

Silver sulfadiazine may interact with other medications, including antacids, tetracyclines, macrolides, anticoagulants, ACE inhibitors, statins, and sulfonylureas. Always inform your doctor about any other medications you are taking before using silver sulfadiazine.

Disease Interactions

Silver sulfadiazine may interact with certain medical conditions, including G6PD deficiency, kidney and liver disease, and autoimmune disorders. It is important to inform your doctor of any medical condition before using silver sulfadiazine.

Drug Interactions

Silver sulfadiazine may interact with certain medications, including antacids, tetracyclines, macrolides, anticoagulants, ACE inhibitors, statins, and sulfonylureas. Always inform your doctor of any medications you are taking before using silver sulfadiazine.

Food Interactions

Silver sulfadiazine is not known to interact with food.

Pregnancy Use

Silver sulfadiazine should not be used during pregnancy as it may cause harm to a developing fetus. If you are pregnant or planning to become pregnant, consult your doctor before using silver sulfadiazine.

Lactation Use

Silver sulfadiazine should not be used during lactation as it may cause harm to the infant. It is not known if this drug is excreted in human milk. Consult your doctor before using silver sulfadiazine.

Acute Overdose

An overdose of silver sulfadiazine can be dangerous. If an overdose is suspected, seek medical help immediately.

Contraindication

Silver sulfadiazine should not be used in patients who are allergic or hypersensitive to sulfonamides or silver-based medications. It should also not be used on open wounds or on areas of the skin which are inflamed, infected, or irritated.

Use Directions

Apply a thin layer of 1% cream over the entire wound area two to three times daily and cover with an occlusive bandage or dressing. Avoid any contact with eyes and wash the hands after application. Do not use on open wounds.

Storage Condition

Store silver sulfadiazine at room temperature, away from heat and direct sunlight. Keep away from children and pets.

Volume of Distribution

Silver sulfadiazine is not absorbed through the skin and does not have a volume of distribution.

Half Life

Silver sulfadiazine is not orally or systemically absorbed, so it does not have a half-life.

Clearance

Silver sulfadiazine is not absorbed systemically so clearance is not an issue.

Here you find in details version of Dersa

Some Frequently Asked Questions About Dersa

What is Dersa?

Dersa, also known as SSD or Silvadene, is a topical, Wagner-modified sulfonamide antibiotic used as a first-line treatment for burn wounds in order to prevent infection.

Is Dersa safe to use?

Yes, silver sulfadiazine is generally considered safe to use. However, it is important to speak to a doctor first to be absolutely sure it is safe to use.

What are the side effects of Dersa?

Common side effects of silver sulfadiazine include skin irritation and hypersensitivity reactions. Rare but serious side effects may include Stevens Johnson Syndrome, anaphylaxis, and granulocytopenia.

What is Dersa used for?

Silver sulfadiazine is mainly used as a topical treatment for second- and third-degree burns. It helps to prevent infection and promote healing by killing bacteria on the skin's surface.

How often should I use Dersa?

It is important to follow your doctor's instructions for using silver sulfadiazine, as your doctor may recommend a specific frequency for its use. Generally speaking, silver sulfadiazine is applied every 8 to 12 hours.

Can I use Dersa on my face?

Yes, silver sulfadiazine can be used on the face. However, it is important to follow your doctor's instructions for its use, as they may provide additional guidance or precautions that need to be taken when using silver sulfadiazine on the face.

Is Dersa a steroid?

No, silver sulfadiazine is not a steroid. Silver sulfadiazine is an antibiotic that helps to prevent infection and promote healing in burn wounds.

Are there any interactions between Dersa and other medications?

Yes, silver sulfadiazine may interact with a variety of medications, including other antibiotics. It is important to speak to a doctor or pharmacist about any potential interactions before using silver sulfadiazine.

How should I store Dersa?

It is important to store silver sulfadiazine at room temperature, away from heat, moisture, and light. Additionally, it is important to keep the medication out of the reach of children.

What should I do if I miss a dose of Dersa?

If you miss a dose of silver sulfadiazine, it is important to apply the missed dose as soon as possible. However, if it is close to your next scheduled dose, you should skip the missed dose and resume your usual dosing schedule.

Can Dersa be used on pets?

No, silver sulfadiazine is approved for use in humans only. It should not be used on pets.

When should I stop using Dersa?

It is important to follow your doctor's instructions for using silver sulfadiazine. Generally speaking, silver sulfadiazine should be used until the burn wound has healed properly.

Can Dersa be used to treat diaper rash?

No, silver sulfadiazine should not be used to treat diaper rash. Diaper rash is commonly treated with topical creams or ointments.

Can Dersa be used while pregnant or breastfeeding?

It is recommended to speak to a doctor before using silver sulfadiazine while pregnant or breastfeeding, as there may be risks associated with its use.

Is Dersa available over the counter?

No, silver sulfadiazine is a prescription medication and is not available over the counter.

What is the difference between Dersa and Silver Nitrate?

Dersa is an antibiotic that is used to treat bacterial infections in burns, while Silver Nitrate is a caustic agent that is used to treat various skin conditions, including warts, fungal infections, and corns.

Can Dersa be used on open wounds?

Yes, silver sulfadiazine can be used to treat open wounds, as long as the wound is not infected. If the wound is infected, an oral antibiotic may be prescribed instead.

Can Dersa be used to treat acne?

No, silver sulfadiazine should not be used to treat acne. Acne is usually treated with topical creams, oral medications, or laser treatments.

Is Dersa a sulfa drug?

Yes, silver sulfadiazine is a sulfonamide antibiotic, and is commonly referred to as a sulfa drug.

How quickly does Dersa work?

Silver sulfadiazine begins working as soon as it is applied to the skin. However, it may take several days to weeks for the burn wound to heal completely.

What is the difference between Dersa and Silvadene cream?

Dersa and Silvadene cream are both topical antibiotics used to treat burn wounds. Dersa is the generic name for the medication, while Silvadene is the brand name for the medication.

What are the proper steps for applying Dersa?

The proper way to apply silver sulfadiazine is to apply a thin layer to the affected area, rubbing it lightly in a circular motion. A non-adherent dressing may then be placed on top of the silver sulfadiazine. It is important not to cover the silver sulfadiazine with a bandage.

Are there any precautions I should take when using Dersa?

Yes, it is important to take precautions when using silver sulfadiazine. It is recommended to wear gloves while applying the medication, and it should not be applied to broken skin, cuts, or irritated areas. Additionally, it should not be used near the eyes, mouth, or nose.

What should I do if I experience a severe allergic reaction while using Dersa?

If you experience a severe allergic reaction while using silver sulfadiazine, it is important to seek medical attention immediately. Symptoms of a severe allergic reaction can include hives, difficulty breathing, and swelling of the face, lips, tongue, or throat.

Can Dersa be used to treat skin infections?

Yes, silver sulfadiazine is commonly used to treat bacterial skin infections. It helps to kill bacteria on the skin's surface, reducing the risk of infection and promoting healing.

Does Dersa have antifungal properties?

No, silver sulfadiazine does not have any antifungal properties. It is used mainly as an antibiotic to help kill bacteria on the skin's surface.

Is Dersa safe to use on children?

Yes, silver sulfadiazine is generally considered safe to use on children, as long as it is used according to the instructions provided by the doctor. However, it is recommended to speak to a doctor first to confirm it is safe to use.

Should Dersa be applied directly to the wound?

Yes, silver sulfadiazine should be applied directly to the wound. It is important to clean the wound before applying the silver sulfadiazine.

Can Dersa be used to treat athlete's foot?

No, silver sulfadiazine should not be used to treat athlete's foot. Athlete's foot is usually treated with antifungal creams, sprays, and powders.

Can Dersa be used on a sunburn?

No, silver sulfadiazine should not be used on a sunburn. Sunburns are usually treated with a topical cream to help soothe the skin, as well as prevent infection. Additionally, it is important to drink plenty of fluids and to take pain medications, if necessary.

Can Dersa be used with other topical medications?

Yes, silver sulfadiazine can be used with other topical medications. However, it is important to speak to a doctor or pharmacist first to ensure that it is safe to use the other medications in combination with silver sulfadiazine.

Is Dersa an antibiotic?

Yes, silver sulfadiazine is a topical, Wagner-modified sulfonamide antibiotic.

Can Dersa be used on eczema?

No, silver sulfadiazine should not be used on eczema. Eczema is usually treated with topical creams or ointments to reduce inflammation and itching.

Can Dersa cause a rash?

Yes, silver sulfadiazine may cause a rash. If you experience a rash while using silver sulfadiazine, it is important to discontinue use of the medication and speak to your doctor.

Can Dersa be used on scars?

No, silver sulfadiazine should not be used on scars. It is intended to be used on open wounds and should not be used on scars.

Does Dersa stain clothing?

Yes, silver sulfadiazine may stain clothing. It is important to wear clothing that is easily washable and to avoid getting the medication on clothing.

When should I expect to see results after applying Dersa?

Silver sulfadiazine begins working as soon as it is applied to the skin. However, significant results may not be seen for several days or weeks, depending on the severity of the burn wound.

Is Dersa the same as Neosporin?

No, silver sulfadiazine is not the same as Neosporin. Neosporin is a formulation of three antibiotics that is used to treat minor cuts, scrapes, and burns, while silver sulfadiazine is a topical Wagner-modified sulfonamide antibiotic that is used to treat second- and third-degree burns.

How should I dispose of unused Dersa?

Any unused silver sulfadiazine should be disposed of according to the guidelines provided by your doctor or pharmacist.