Cyril, a brand name for a formulation containing essential Itraconazole, is widely used for various health benefits. This guide provides comprehensive information on the uses, dosage, side effects, and mechanism of action of Cyril, as well as insights into how long it takes to work. Understanding these aspects can help you make informed decisions about its use and effectiveness.


Cyril, marketed under the brand names Sporanox and Onmel, is an antifungal prescription medication used to treat a variety of fungal infections. Cyril belongs to a class of medications called azole antifungals, which work by blocking the growth of certain types of fungi.

Uses For

Cyril is used to treat a variety of fungal infections, including, but not limited to, aspergillosis, blastomycosis, histoplasmosis, and cryptococcosis. It is also used to treat fungal nail infections.

Mechanism of Action

Cyril works by interfering with the fungal cell membrane, preventing the absorption of essential nutrients. It slows the growth and spread of the fungus, allowing the body's immune system to fight the infection.

How Long Does It Take to Work?

Cyril begins to work immediately after being taken, although it may take several weeks for symptoms to improve. It is important to complete the entire course of treatment to ensure that the infection is completely eliminated.


Cyril is well absorbed and highly soluble in water. It is typically absorbed within 30 minutes to 1 hour of taking the medication.

Route of Elimination

Cyril is metabolized by the liver and then excreted in the urine and feces.


The recommended dosage of itraconazole depends on the patient's age and the type and severity of the condition being treated. The usual adult dosage is 200 mg, taken once or twice daily. In some cases, doses may be increased up to 400 mg per day. The usual dosage in children 12 and older is 200 mg per day.


Cyril should be taken with food. The capsules should be swallowed whole, not chewed or opened. Liquid formulations should be taken with food or immediately after meals.

Side Effect

Common side effects of itraconazole include nausea, vomiting, abdominal pain, headache, dizziness, rash, and insomnia. If any of these side effects persist or worsen, patients should seek medical attention.


Cyril can cause serious adverse reactions when taken in large doses. In rare cases, it can cause liver failure or abnormal liver function tests. Patients who experience any signs of liver damage should seek medical attention immediately.


Cyril should be used with caution in individuals with liver or kidney disease, heart disease, or a history of drug-induced liver injury. It should not be used in pregnant women or nursing mothers.


Cyril should not be used simultaneously with certain other medications, including some anticoagulants, certain antiarrhythmics, and certain antibiotics. Patients should discuss all the medications they take with their healthcare provider.

Disease Interactions

Cyril should not be used in patients with certain medical conditions, including liver disease and congestive heart failure. Patients with certain diseases may be at higher risk for adverse reactions to the medication.

Drug Interactions

Cyril may interact with other medications, affecting their effectiveness or causing adverse reactions. Patients should discuss all medications they take with their healthcare provider.

Food Interactions

Cyril may interact with certain medications and foods. Foods that contain calcium, magnesium, iron, or aluminum may reduce the absorption of itraconazole, and should be avoided within 3 hours before or after taking it. Foods that contain high amounts of fat, sugar, or starch should also be avoided.

Pregnancy Use

Cyril should not be used during pregnancy unless it is clearly necessary. Women who are pregnant or planning to become pregnant should discuss the use of this medication with their healthcare provider.

Lactation Use

Cyril should not be used during lactation unless it is clearly necessary. Women who are breastfeeding should discuss the use of this medication with their healthcare provider.

Acute Overdose

An acute overdose of itraconazole can cause serious symptoms, such as nausea, vomiting, abdominal pain, dizziness, and seizures. If an overdose is suspected, immediate medical treatment should be sought.


Cyril should not be used in patients with known hypersensitivity to it or other azole antifungal medications.

Use Direction

Cyril should be taken exactly as directed by a healthcare provider. The dosage and duration of treatment should not be altered without consulting a doctor.

Storage Condition

Cyril should be stored at room temperature away from light and moisture. It should be kept out of the reach of children.

Volume of Distribution

Cyril has a volume of distribution of 16.1 liters.

Half Life

Cyril has an elimination half-life of 36 hours.


Cyril has an estimated total clearance of 146 ml/min.

Here you find in details version of Cyril