Cordarone

Cordarone Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Cordarone is a brand name. Its generic name is Amiodarone.

Introduction

Cordarone is an antiarrhythmic medicine which is used to treat abnormally rapid heartbeats (arrhythmias). It is sold by the trade name Cordarone. It is used to treat life-threatening arrhythmias, and has been found to be useful in helping to keep patients’ heart rhythms back in a normal rhythm.

Uses For

Cordarone is used to treat life-threatening arrhythmias, including ventricular tachycardia, ventricular fibrillation, and atrial fibrillation (an abnormal form of rapid heartbeat). It can also be used to treat atrial flutter, and is useful in preventing or lessening recurrent arrhythmias.

Mechanism of Action

Cordarone works by slowing down the nerve signals that control the heart rate. This helps to slow the arrhythmia, which helps to increase the heart’s oxygen supply, and helps to restore the heart’s normal rhythm. Cordarone also has an anti-inflammatory effect which may help to reduce the damage to the heart during an arrhythmia episode.

How Long Does it Take to Work?

Cordarone generally takes effect within one to two weeks of starting the treatment. The best results, however, come after continued use for at least three to six months.

Absorption

Cordarone is taken orally and is absorbed quickly and completely into the bloodstream.

Route of Elimination

Cordarone is eliminated primarily by the liver in the form of inactive metabolites. A small portion of the drug is also eliminated through the kidneys and bile.

Dosage

For adult patients, the usual oral dose for arrhythmias is 400mg to 1600mg daily, given in divided doses three to four times per day. Dosage modifications may be necessary for patients who have liver or kidney disease, or for those taking other medications.

Administration

Cordarone should be taken with or without food at least one hour before a meal. It should be taken as prescribed by your doctor or pharmacist.

Side Effects

The most common side effects from amiodarone include nausea, vomiting, dizziness, lightheadedness, headache, diarrhea, loss of appetite, and skin rash. Some rare but serious side effects may include liver toxicity, lung toxicity, vision changes, and thyroid problems.

Toxicity

Cordarone can be potentially toxic if taken in overdose. Symptoms of overdose may include vomiting, confusion, difficulty breathing, light sensitivity, and loss of consciousness.

Precautions

It is important to tell your doctor or pharmacist about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you are taking. Cordarone should be used with caution in patients with low blood pressure, impaired liver or kidney function, or certain heart conditions.

Interactions

Cordarone may interact with some other medications, including blood pressure medicines, aminoglycosides, digoxin and quinidine. Certain drugs should be avoided while taking amiodarone, as they may increase the risk of side effects. This includes drugs such as wasabi or horseradish.

Disease Interactions

Patients with certain heart conditions, such as heart block, may be at an increased risk of developing arrhythmia while taking amiodarone. Therefore, such patients should be carefully monitored for any changes in their condition. Cordarone should also be used with caution in patients with a history of liver or kidney disease.

Drug Interactions

Cordarone may interact with certain drugs, such as aminoglycosides, calcium channel blockers, digoxin, and quinidine. Consult your doctor or pharmacist before starting or stopping any medication or supplements while taking amiodarone.

Food Interactions

Cordarone should be taken at least one hour before or after meals, to minimize the risk of interaction with certain foods. Foods that contain high amounts of vitamin K or omega-3 fatty acids may increase the risk of side effects when taken with amiodarone.

Pregnancy Use

Cordarone has not been adequately studied in pregnant women. Therefore, it should be used during pregnancy only if the potential benefit justifies the potential risk to the unborn baby. Women should also be advised to not breastfeed while taking amiodarone.

Lactation Use

Cordarone has not been adequately studied in breastfeeding women. Because of the potential risk to the infant, women who are breastfeeding should not take amiodarone.

Acute Overdose

Symptoms of an acute overdose may include excessive drowsiness, confusion, lightheadedness, slow heart rate, and muscle weakness. Contact your doctor or healthcare provider immediately if you experience any of these symptoms.

Contraindication

Cordarone is contraindicated in patients with certain medical conditions, such as low blood pressure (hypotension), second or third degree heart block, or a history of slow heart rate (bradycardia). It is also contraindicated in patients taking drugs known to cause severe or life-threatening arrhythmias.

Use Direction

Cordarone should be taken as prescribed by your doctor or pharmacist. It should also be taken at least one hour before or after meals, to minimize the risk of interactions with certain foods.

Storage Condition

Cordarone should be stored at room temperature, away from direct light and moisture. It should be kept in a tight container. Keep out of the reach of children.

Volume of Distribution

Approximately 8-40 liters (32-160 ounces) of amiodarone is distributed throughout the body following a single oral dose.

Half Life

The elimination half-life of amiodarone typically ranges from 10-60 hours, meaning that up to 60 hours may be needed for the drug to be completely eliminated from the body.

Clearance

Cordarone is eliminated primarily by the liver. It is also eliminated through the kidneys and bile.

Here you find in details version of Cordarone

Some Frequently Asked Questions About Cordarone

What is Cordarone?

Cordarone is an antiarrhythmic medication used to treat irregular heart rhythms, also known as arrhythmias. It is sold under the brand name Cordarone, and is sometimes referred to by the generic name amiodarone hydrochloride.

How does Cordarone work?

Cordarone works by blocking the action of certain electrical pathways in the heart. By doing so, it helps to keep the heart in a regular, steady rhythm. It also helps to slow down the heart rate if it is beating too fast.

What are the side effects of Cordarone?

Common side effects of Cordarone include nausea, vomiting, diarrhea, constipation, dizziness, headache, blurred vision, and a metallic taste in the mouth. More serious side effects may include liver or lung damage, low white or red blood cell counts, rash, extreme fatigue, cardiac arrhythmia, and heart block. In rare cases, Cordarone may cause an eye disorder called uveitis.

Can Cordarone cause weight gain?

Yes, Cordarone can cause weight gain. In addition, Cordarone can cause an increase in appetite, which can contribute to weight gain as well.

What should I do if I experience any side effects while taking Cordarone?

If you experience any side effects while taking Cordarone, you should contact your doctor immediately. Be sure to mention any new or worsening side effects.

How long does it take for Cordarone to start working?

Cordarone usually takes several weeks to start working. The full effects of the medication may not be seen for up to 6 months. Be sure to take the medication exactly as prescribed for the best results.

Can Cordarone be taken with other medications?

Yes, Cordarone can be taken with other medications, but it is important to tell your doctor if you take any medications regularly. Certain medications may interact with Cordarone and cause serious side effects.

Does Cordarone cause birth defects?

Yes, Cordarone has been linked to an increased risk of birth defects, including heart defects, when taken during the first three months of pregnancy. Women who are pregnant or planning to become pregnant should talk to their doctor before starting Cordarone.

What should I do if I miss a dose of Cordarone?

If you miss a dose of Cordarone, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose as scheduled. Do not take a double dose of Cordarone.

Can I take Cordarone while breastfeeding?

No, it is not recommended to take Cordarone while breastfeeding. Some of the medication can pass into breast milk and it may cause serious side effects in a nursing infant.

Does Cordarone interact with alcohol?

Yes, it is not recommended to drink alcohol while taking Cordarone. Alcohol can interact with the medication and cause an increased risk of side effects, including dizziness and drowsiness.

How should Cordarone be stored?

Cordarone should be stored at room temperature. Keep the medication in a dry place, away from direct heat and sunlight. Do not store Cordarone in the bathroom.

Can I take Cordarone if I have a history of heart failure?

Yes, Cordarone can be used to treat arrhythmias in patients with a history of heart failure. However, it is important to tell your doctor about any history of heart failure before starting the medication.

What should I do if my symptoms don't improve while taking Cordarone?

If your symptoms don't improve while taking Cordarone, contact your doctor right away. Your doctor may need to adjust your dose or switch your medication.

Can Cordarone be used to treat ventricular tachycardia?

Yes, Cordarone is often used to treat ventricular tachycardia, a type of arrhythmia. It can also be used to treat atrial fibrillation and atrial flutter.

Can I take over-the-counter medications while taking Cordarone?

Yes, you can take over-the-counter medications while taking Cordarone, but always check with your pharmacist or doctor first. Certain medications may interact with Cordarone and cause serious side effects.

Can Cordarone cause permanent damage to the heart?

No, Cordarone does not typically cause permanent damage to the heart. However, long-term use of the medication may cause other side effects, including lung and liver damage.

Does Cordarone interact with other herbs or supplements?

Yes, Cordarone can interact with certain herbs and supplements. Be sure to tell your doctor if you take any vitamins, minerals, or herbal supplements, as some of these can interfere with the medication.

Can Cordarone be used to treat atrial fibrillation?

Yes, Cordarone is often used to treat atrial fibrillation, as well as other types of arrhythmias. It can also be used to treat atrial flutter.

What other conditions can Cordarone be used to treat?

In addition to treating arrhythmias, Cordarone is sometimes used to treat ventricular tachycardia, bradycardia, and atrial fibrillation. It may also be used to treat certain types of chest pain.

When should I take Cordarone?

You should take Cordarone exactly as prescribed by your doctor. In general, it is taken once a day, either with or without food. You should also drink plenty of fluids while taking the medication.

Can I stop taking Cordarone if my symptoms improve?

No, you should never stop taking Cordarone without first talking to your doctor. Abruptly discontinuing the medication may cause your arrhythmias to worsen.

Can Cordarone make my skin sensitive to sunlight?

Yes, Cordarone can make your skin more sensitive to sunlight. Be sure to wear sun-protective clothing and use sunscreen when going outdoors, even for short periods of time.

Can I take Cordarone if I have low blood pressure?

Yes, Cordarone can be used to treat arrhythmias in patients with low blood pressure. However, you should tell your doctor about any history of low blood pressure before starting the medication.

Can Cordarone be used in children?

Yes, Cordarone can be used to treat certain arrhythmias in children. However, the dosage is based on the child's weight and age, so it is important to speak to your doctor before starting any medication for a child.

Is Cordarone habit forming?

No, Cordarone is not habit forming. However, it is important to take the medication as prescribed to ensure the best results.

Does Cordarone cause hair loss?

Yes, hair loss is a possible side effect of Cordarone. If you notice hair loss or changes in your hair texture or color while taking Cordarone, make sure to tell your doctor.

Does Cordarone increase the risk of blood clots?

Yes, Cordarone may increase the risk of abnormal blood clots forming in the body. If you experience any unusual pain or swelling while taking Cordarone, contact your doctor right away.

Can I take Cordarone if I have an allergy to iodine?

No, it is not advised to take Cordarone if you are allergic to iodine. Speak to your doctor before starting any new medication, as some medications contain iodine or other substances that can cause an allergic reaction.

Does Cordarone cause liver damage?

Yes, long-term use of Cordarone may cause liver damage. Be sure to tell your doctor if you experience any signs of liver problems, such as dark urine, jaundice, or appetite loss.

Can Cordarone be used to treat atrial flutter?

Yes, Cordarone is often used to treat atrial flutter, a type of arrhythmia. It is also used to treat ventricular tachycardia and atrial fibrillation.

How long does it take for Cordarone to be effective?

Cordarone usually takes several weeks to start working. The full effects of the medication may not be seen for up to 6 months. Be sure to take the medication exactly as prescribed for the best results.

What other drugs interact with Cordarone?

There are a number of drugs that can interact with Cordarone, including certain antibiotics, antifungals, and HIV medications. Be sure to tell your doctor about any medications you are taking before starting Cordarone.

Can I take Cordarone if I have a history of thyroid disease?

Yes, Cordarone can be used to treat arrhythmias in patients with a history of thyroid disease. However, you should tell your doctor if you have a history of thyroid disorder before starting Cordarone.

What should I do if I vomit after taking Cordarone?

If you vomit shortly after taking Cordarone, contact your doctor as soon as possible. You may need to take a replacement dose of the medication.

Can I take Cordarone if I am pregnant?

No, it is not recommended to take Cordarone while pregnant. Cordarone has been linked to an increased risk of birth defects, including heart defects, when taken during the first three months of pregnancy.

Can Cordarone cause dizziness?

Yes, dizziness is a common side effect of Cordarone. Be sure to take the medication with food and drink plenty of fluids to lessen the risk of dizziness.

Can Cordarone be used to treat bradycardia?

Yes, Cordarone is often used to treat bradycardia, a type of arrhythmia. It can also be used to treat ventricular tachycardia and atrial fibrillation.