Contine

Contine Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Contine is a brand name. Its generic name is Memantine.

What is Contine?

Contine is an N-methyl-D-aspartate (NMDA) receptor antagonist that is prescribed for the treatment of moderate to severe Alzheimer's disease. It works by preventing over-excitement in the brain and thus helping to restore normal body functions.

Uses of Contine

Contine is approved for the treatment of moderate to severe Alzheimer's disease. It is being studied for treatment of Alzheimer's-related vascular dementia, Parkinson's disease, Huntington's disease, fatigue due to Multiple Sclerosis, and other conditions.

Mechanism of Action

Contine blocks the activity of glutamate, an amino acid that can over-stimulate nerve cells and lead to cell death. By blocking the activity of glutamate, memantine can protect nerve cells from over-stimulation and help restore normal body functions.

How Long Does it Take to Work?

It may take up to 8 weeks for Contine to work. Some people may experience improvement in symptoms sooner than this, while others may not experience any improvement until after 8 weeks of treatment.

Absorption

Contine is rapidly absorbed from the gastrointestinal tract. The peak plasma concentration occurs approximately 1.5 to 2 hours after oral administration.

Route of Elimination

Contine is eliminated primarily by the kidneys. It is metabolized into active metabolites that are excreted unchanged in the urine.

Dosage

The recommended starting dose of memantine is 5 mg twice daily. The dose can be increased to 10 mg twice daily after 1 week and, if needed, 20 mg twice daily after 2 weeks. The maximum recommended dose is 20 mg twice daily.

Administration

Contine is usually taken orally. The tablets should be swallowed with a glass of water. Contine can be taken with or without food.

Side Effects

Common side effects of memantine include headache, dizziness, nausea, vomiting, constipation, and fatigue. Other serious side effects include the worsening of psychiatric symptoms, increased blood pressure, and seizures.

Toxicity

Contine is not likely to be toxic at therapeutic doses. The most common side effects are mild and may go away with continued use. Significant toxicity is unlikely at therapeutic doses.

Precautions

Contine should not be used in people with severe kidney disease, as it may increase the risk of adverse effects. Caution should be exercised when administering memantine to elderly people with a history of stroke, as memantine may worsen their symptoms.

Interactions

Contine may interact with many other medications including sedatives, tricyclic antidepressants, other anticholinergic medications, anticonvulsants, MAO inhibitors, and certain antibiotics. It is important to check with a physician before taking Contine with any other medications.

Disease Interactions

People with Alzheimer's disease, stroke, kidney disease, depression, and certain other conditions should not take Contine. People with these conditions should check with their doctor before using Contine.

Drug Interactions

Contine may interact with other medications and substances, such as nicotine, coffee, and certain vitamins and minerals. It is important to check with a physician before taking Contine with any other medications or substances.

Food Interactions

It is important to take Contine at least one hour before or two hours after eating. Certain foods may interact with Contine, such as dairy products, high-fat meals, and iron supplements. Therefore, it is advisable to avoid these foods and supplements when taking Contine.

Pregnancy Use

Contine is not recommended for use during pregnancy. Women should consult with their health care provider before taking Contine while pregnant.

Lactation Use

It is not known if Contine passes into breast milk. Women should consult with their health care provider before taking Contine while breastfeeding.

Acute Overdose

Symptoms of an acute overdose of Contine may include drowsiness, confusion, hallucinations, and seizures. Treatment for an overdose of Contine may include supportive care and/or administration of activated charcoal to reduce absorption.

Contraindications

Contine is contraindicated in people with severe kidney disease, as it may increase the risk of adverse effects. Contine is also contraindicated in people with a history of stroke, as it may worsen their symptoms.

Dosing Instructions

The recommended starting dose of memantine is 5 mg twice daily. The dose can be increased to 10 mg twice daily after 1 week and, if needed, 20 mg twice daily after 2 weeks. The maximum recommended dose is 20 mg twice daily. Contine should be taken at least one hour before or two hours after eating.

Storage Conditions

Contine should be stored at room temperature, in a dry place away from light. Do not keep Contine in the refrigerator or freezer.

Volume of Distribution

The volume of distribution of Contine is 0.6L/kg. This indicates that Contine is found throughout the body, including in tissues.

Half-Life

The half-life of Contine is 36 hours. This indicates that it takes 36 hours for the level of Contine in the body to be reduced by 50%.

Clearance

Contine is primarily cleared by the kidneys. It is metabolized into active metabolites that are excreted unchanged in the urine.

Here you find in details version of Contine

Some Frequently Asked Questions About Contine

What is Contine?

Contine is a prescription medicine used to treat moderate to severe Alzheimer’s disease. It is also used to treat certain types of pain, such as certain nerve pain and spasticity. It belongs to a class of drugs called N-methyl-D-aspartate (NMDA) receptor antagonists.

What are the side effects of Contine?

Common side effects of Contine include nausea, diarrhea, sleepiness, headache, confusion, dizziness, lost of appetite, constipation, muscle pain, and vomiting. Less common side effects include difficulty urinating, agitation, blurred vision, chest pain, decreased sexual interest, and swelling of the feet and ankles.

Can Contine be used to treat other conditions?

Contine can be used to treat certain types of pain, such as certain nerve pain and spasticity, but it is not approved by the FDA for any other indications.

Does Contine have any interaction with other drugs?

Yes, Contine can interact with certain drugs such as antidepressants, antihistamines, antibiotics, heartburn medications, and seizure medications. Check with your doctor or pharmacist if you are taking any other medications.

Is Contine safe?

Yes, Contine is generally safe when taken as prescribed. However, some side effects may occur, so it is important to follow your doctor’s directions and read the medication guide to understand potential side effects.

Is Contine available in generic form?

Yes, Contine is available in generic form. It is important to talk with your doctor or pharmacist about your specific medication and how to use it safely.

What is the recommended dosage of Contine?

The recommended dosage of Contine depends on your condition and age. Follow your doctor’s instructions and read the medication guide carefully for the recommended dosage.

How long does it take for Contine to work?

It typically takes several weeks for Contine to start working. Your doctor may adjust your dose depending on your response to the medicine.

Can Contine be taken with food?

Yes, Contine can be taken with food. However, it is best to take it at the same time every day.

Can Contine cause weight gain?

Yes, weight gain is a possible side effect of Contine. Talk to your doctor if you experience rapid weight gain while taking this medication.

Can Contine be used during pregnancy?

No, Contine should not be used during pregnancy, unless your doctor has determined that the benefits outweigh the risks. It is important to talk to your doctor before taking any medication during pregnancy.

Can Contine be taken with other drugs for Alzheimer's?

Yes, Contine can be taken with other drugs for Alzheimer's. However, some medications may interact with each other, so it is important to talk to your doctor before taking any other medication.

What should I avoid while taking Contine?

While taking Contine, you should avoid drinking alcohol, driving, or operating machinery until you know how this drug affects you. You should also avoid activities that require careful attention. If you experience drowsiness or dizziness while taking this medication, avoid these activities.

Can I overdose on Contine?

Yes, it is possible to overdose on Contine. If you or someone you know has overdosed on this medication, seek emergency medical help immediately.

Can I stop taking Contine on my own?

No, you should not stop taking Contine on your own. Talk to your doctor before making any changes to your medication regimen.

What should I do if I am unable to find Contine?

If you are unable to find Contine at your local pharmacy, ask your doctor to call in a prescription or consider switching to a generic version of the medication.

Does Contine interact with other medical conditions?

Yes, Contine can interact with other medical conditions such as kidney failure, dementia, and seizure disorders. Talk to your doctor about any other medical conditions you have before taking this medication.

Can I take Contine if I have kidney problems?

Yes, you can take Contine if you have kidney problems, but your doctor may adjust your dose to reduce the risk of side effects. Talk to your doctor about any other medical conditions you have before taking this medication.

Can I take Contine if I am taking other medications?

Yes, you can take Contine if you are taking other medications, but some medications may interact with each other. Check with your doctor or pharmacist before taking any other medications while taking Contine.

Can I split a dose of Contine?

No, you should not split a dose of Contine. Talk to your doctor or pharmacist about the proper dosage for your condition.

Are there any special storage instructions for Contine?

Yes, it is important to store Contine at room temperature away from light and moisture. Talk to your pharmacist for more information.

Is there a generic version of Contine available?

Yes, there is a generic version of Contine available. Talk to your doctor or pharmacist about your specific medication and how to use it safely.

Does Contine come in a liquid form?

No, Contine does not come in a liquid form. It is available as a tablet, capsule, and solution.

What are the common side effects of Contine?

Common side effects of Contine include nausea, diarrhea, sleepiness, headache, confusion, dizziness, lost of appetite, constipation, muscle pain, and vomiting.

Can I drink alcohol while taking Contine?

No, you should not drink alcohol while taking Contine. Alcohol may increase the risk of side effects and can interact with this medication.

Can I take Contine if I am breastfeeding?

No, Contine should not be taken while breastfeeding, as it can pass into breast milk and cause serious harm to a nursing infant. Talk to your doctor before taking any medication while breastfeeding.

Is Contine used to treat depression?

No, Contine is not used to treat depression. It is used to treat Alzheimer's disease and certain types of pain such as nerve pain and spasticity.

Can I take Contine if I'm allergic to peanuts?

Yes, it is possible to take Contine if you are allergic to peanuts. But you should check with your doctor to make sure that the medication does not contain ingredients that can cause an allergic reaction.

Does Contine help with dementia?

Yes, Contine can help slow the progression of dementia symptoms in some people. Talk to your doctor to discuss whether this medication is right for you.

Does taking Contine cause memory loss?

No, taking Contine does not cause memory loss. In fact, it can help slow the progression of memory loss associated with Alzheimer's disease.

Is there an over-the-counter version of Contine?

No, Contine is a prescription medication and is not available over-the-counter.

How quickly does Contine start working?

It typically takes several weeks for Contine to start working. Your doctor may adjust your dose depending on your response to the medicine.

Does Contine have any long-term side effects?

Yes, long-term side effects of Contine may include confusion, dizziness, drowsiness, nausea, constipation, and headache. Talk to your doctor if you are experiencing any of these side effects.

Does Contine cause insomnia?

Yes, insomnia is a possible side effect of Contine. Talk to your doctor if you experience difficulty sleeping while taking this medication.

Can I take herbal supplements while taking Contine?

No, you should not take herbal supplements while taking Contine. Some herbal supplements may interact with this medication and cause serious side effects.

Can I take Contine if I have a history of stroke?

Yes, you can take Contine if you have a history of stroke, but your doctor may adjust your dose to reduce the risk of side effects. Talk to your doctor before taking any medication.

What should I do if I forget to take my dose of Contine?

If you forget to take a dose of Contine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the next dose at your regular time.

Can I take Contine if I am pregnant?

No, Contine should not be used during pregnancy, unless your doctor has determined that the benefits outweigh the risks. It is important to talk to your doctor before taking any medication during pregnancy.

Can I take Contine if I have heart problems?

Yes, you can take Contine if you have heart problems, but your doctor may adjust your dose to reduce the risk of side effects. Talk to your doctor about any other medical conditions you have before taking this medication.

What is the difference between Contine and Cholinesterase inhibitors?

Contine is a N-methyl-D-aspartate (NMDA) receptor antagonist used to treat moderate to severe Alzheimer's disease, while Cholinesterase inhibitors are used to treat mild to moderate Alzheimer's disease. Talk to your doctor to determine which medication is right for you.